Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine

Gastrointestinal Disorders, Год журнала: 2025, Номер 7(1), С. 7 - 7

Опубликована: Янв. 15, 2025

The human microbiome, a complex ecosystem of microorganisms residing in and on the body, plays pivotal role regulation wide range physiological processes, including digestion, immune responses, metabolic functions. In recent years, rapidly growing field microbiome-driven therapeutics has garnered significant attention owing to its potential revolutionize healthcare. This review explores evolving landscape microbiome-based therapies, with particular focus gut microbiome implications for both health precision medicine. We highlight advances understanding how microbial communities influence disease pathogenesis treatment outcomes, spanning conditions such as inflammatory bowel (IBD), disorders, neurological diseases, even cancer. article also discusses emerging therapeutic strategies, probiotics, prebiotics, fecal microbiota transplantation (FMT), microbial-based drugs, well challenges associated their clinical implementation. Additionally, we examined integration profiling metagenomic data is advancing medicine, paving way personalized effective treatments. serves comprehensive resource that synthesizes current knowledge, identifies key gaps research, offers insights into future direction therapeutics, thus providing valuable framework clinicians, researchers, policymakers seeking harness microbiomes advance healthcare solutions.

Язык: Английский

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Nourishing the Mind: How Food Security Influences Mental Wellbeing

Nutrients, Год журнала: 2024, Номер 16(4), С. 501 - 501

Опубликована: Фев. 9, 2024

Food insecurity is a significant public health problem worldwide and critical to mental health. There complex relationship between food security We carried out narrative review study aiming address how impacts wellbeing by focusing on the repercussions of insecurity, recognizing its pivotal role in attaining Sustainable Development Goals 2 (on hunger) 3 enhancing global wellbeing). A comprehensive search was conducted PubMed Google Scholar, incorporating searches for pertinent reports policy documents. To these questions, we emphasized elucidated interconnectedness The shows that share profound influenced multifaceted factors like socioeconomic conditions, access nutritious food, societal inequalities. then provide recommendations integrating into strategies based insights conclusions drawn. Strategies ranging from sustainable farming practices urban agriculture initiatives digital services demonstrate avenues safety wellbeing. This highlights need collaborative interdisciplinary efforts systemic reforms interconnected challenges.

Язык: Английский

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Nutraceuticals in Psychiatric Disorders: A Systematic Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4824 - 4824

Опубликована: Апрель 28, 2024

Correct nutrition and diet are directly correlated with mental health, functions of the immune system, gut microbiota composition. Diets a high content some nutrients, such as fibers, phytochemicals, short-chain fatty acids (omega-3 acids), seem to have an anti-inflammatory protective action on nervous system. Among nutraceuticals, supplementation probiotics omega-3 plays role in improving symptoms several disorders. In this review, we collect data efficacy nutraceuticals patients schizophrenia, autism spectrum disorders, major depression, bipolar disorder, personality This narrative review aims provide overview recent evidence obtained topic, pointing out direction for future research.

Язык: Английский

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The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

Microorganisms, Год журнала: 2024, Номер 12(2), С. 238 - 238

Опубликована: Янв. 23, 2024

Gut luminal dysbiosis and pathobiosis result in compositional biodiversified alterations the microbial host co-metabolites. The primary mechanism of bacterial evolution is horizontal gene transfer (HGT), acquisition new traits can be achieved through exchange mobile genetic elements (MGEs). Introducing genetically engineered microbes (GEMs) might break harmonized balance intestinal compartment. present objectives are: 1. To reveal role played by GEMs’ transfers changing landscape enteric microbiome eubiosis 2. expand on potential detrimental effects those changes human genome health. A search articles published PubMed/MEDLINE, EMBASE, Scielo from 2000 to August 2023 using appropriate MeSH entry terms was performed. exchanges induce multiple diseases. GEMs change long-term natural pro- or eukaryotic cell inhabitants. worldwide regulatory authority’s safety control not enough protect public Viability, biocontainment, many other aspects are only partially controlled harmful consequences for health should avoided. It important remember that prevention most cost-effective strategy primum non nocere focus.

Язык: Английский

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Role of Glial Cells and Receptors in Schizophrenia Pathogenesis

Neurochemical Research, Год журнала: 2025, Номер 50(2)

Опубликована: Янв. 27, 2025

Язык: Английский

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Global research trends in the intestinal microflora and depression: bibliometrics and visual analysis

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Фев. 25, 2025

In recent years, the relationship between gut microbiota and human health has garnered significant attention. Notably, potential connection mental issues, such as depression anxiety, emerged a new focal point for research. While some studies suggest possible link these factors, field remains in its early stages of development, there are notable methodological sample size limitations. This study aims to systematically summarize knowledge systems, research hotspots, development trends related intestinal microflora within context conducted search publications Web Science Core Collection (WOSCC) prior August 6, 2024. The selected literature was subsequently analyzed using VOSviewer (v.1.6.20), SCImago Graphica (v.1.0.39), CiteSpace (v.6.3.1). encompassed total 1,046 publications, demonstrating consistent increase annual publication volume. primary countries identified China United States, with contributions from institutions University California College Cork, among others. Keywords analysis highlighted high-frequency terms including "gut microbiota," "depression," "anxiety," revealed 10 keyword clusters along 20 strongest citation bursts keywords. focus shifted compositional role pathogenesis depression. Research on is growing, but still need greater collaboration authors across regions, more ongoing interaction communication further explore mechanisms action microbiota, develop microbiota-based interventions, facilitate translation findings into clinical practice.

Язык: Английский

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Heterocyclic Antidepressants with Antimicrobial and Fungicide Activity

Molecules, Год журнала: 2025, Номер 30(5), С. 1102 - 1102

Опубликована: Фев. 27, 2025

In this review, the presence of antimicrobial and fungicidal activity in heterocyclic antidepressants was investigated. The already proven connection between intestinal microbiome mental health prompted idea whether these drugs disrupt normal microflora. addition, there is a serious problem increasing resistance microorganisms to antibiotics. article, we found that almost all considered (except moclobemide, haloperidol, doxepin) have can suppress growth not only pathogenic but also bacteria directly affect (such as Lactobacillus, Lactococcus, Streptococcus, Enterococcus, Bifidobacterium).

Язык: Английский

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The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

Опубликована: Янв. 3, 2024

Gut luminal dysbiosis and pathobiosis result in compositional biodiversify alterations the microbial host co-metabolites. The main mechanism of bacterial evolution is horizontal gene transfer (HGT) acquisition new traits can be achieved through mobile genetic element (MGEs) exchange. Introducing genetically engineered microbes (GEMs) might break harmonized balance intestinal compartment. present objectives are: 1. To reveal role played by GEMs' transfers changing landscape enteric microbiome eubiosis 2. expand on potential detrimental effects those changes human genome health. A search articles published PubMed/MEDLINE, EMBASE, Scielo from 2000 to august 2023, using appropriate MeSH entry terms were performed. exchanges induce multiple diseases. GEMs change long-term natural pro- or eukaryotic cells inhabitants. worldwide regulatory authority's safety control not enough protect public Viability biocontainment many other aspects are only partially controlled harmful consequences for health should avoided. Always remember that prevention most cost- effective strategy "primum non nocere" name game.

Язык: Английский

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The Influence of Cecal Microbiota Transplantation on Chicken Injurious Behavior: Perspective in Human Neuropsychiatric Research

Biomolecules, Год журнала: 2024, Номер 14(8), С. 1017 - 1017

Опубликована: Авг. 16, 2024

Numerous studies have evidenced that neuropsychiatric disorders (mental illness and emotional disturbances) with aggression (or violence) pose a significant challenge to public health contribute substantial economic burden worldwide. Especially, social disorganization inequality) associated childhood adversity has long-lasting effects on mental health, increasing the risk of developing disorders. Intestinal bacteria, functionally as an endocrine organ second brain, release various immunomodulators bioactive compounds directly or indirectly regulating host’s physiological behavioral homeostasis. Under challenges, stress-induced dysbiosis increases gut permeability causes serial reactions: releasing neurotoxic compounds, leading neuroinflammation neuronal injury, eventually aggressive, violent, impulsive behavior in humans animals via complex bidirectional communication microbiota–gut–brain (MGB) axis. The dysregulation MGB axis also been recognized one reasons for prevalence injurious behaviors (feather pecking, aggression, cannibalistic pecking) chickens. However, existing knowledge preventing treating these both chickens is not well understood. In previous studies, we developed non-mammal model abnormal investigation by rationalizing microbiota Based our earlier success, perspective article outlines possibility reducing through modifying cecal transplantation, potential providing biotherapeutic rationale among individuals restoring diversity function.

Язык: Английский

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Gut Microbiome Diversity in European Honeybees (Apis mellifera L.) from La Union, Northern Luzon, Philippines

Insects, Год журнала: 2025, Номер 16(2), С. 112 - 112

Опубликована: Янв. 23, 2025

Insects often rely on symbiotic bacteria and fungi for various physiological processes, developmental stages, defenses against parasites diseases. Despite their significance, the associations between bacterial fungal symbionts in Apis mellifera are not well studied, particularly Philippines. In this study, we collected A. from two different sites Municipality of Bacnotan, La Union, A gut microbiome analysis was conducted using next-generation sequencing with Illumina MiSeq platform. Bacterial community compositions were assessed 16S rRNA ITS gene sequences, respectively. Our findings confirm that adult worker bees locations possess distinct but comparably proportioned microbiomes. Key symbionts, including Lactobacillus, Bombilactobacillus, Bifidobacterium, Gilliamella, Snodgrassella, Frischella, identified. The dominated by yeasts Zygosaccharomyces Priceomyces. Using ENZYME nomenclature database PICRUSt2 software version 2.5.2, a predicted functional enzyme revealed presence β-glucosidase, catalase, glucose-6-phosphate dehydrogenase, glutathione transferase, superoxide dismutase, which involved host defense, carbohydrate metabolism, energy support. Additionally, identified notable enzymes, acetyl-CoA carboxylase AMPs nucleosidase. Interestingly, key bee observed to have negative correlation other microbiota. These results provide detailed characterization microbiota associated Philippines lay foundation further metagenomic studies microbiomes native or indigenous species region.

Язык: Английский

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