A Research Domain Criteria (RDoC)-Guided Dashboard to Review Psilocybin Target Domains: A Systematic Review DOI Creative Commons
Niloufar Pouyan,

Zahra Halvaei Khankahdani,

Farnaz Younesi Sisi

и другие.

CNS Drugs, Год журнала: 2022, Номер 36(10), С. 1031 - 1047

Опубликована: Сен. 12, 2022

Preliminary results from randomized controlled studies as well identified molecular, cellular, and circuit targets of select psychedelics (e.g., psilocybin) suggest that their effects are transdiagnostic. In this review, we exploit the Research Domain Criteria (RDoC) transdiagnostic framework, to synthesize extant literature on psilocybin. We aimed identify RDoC-based psilocybin vistas for future mechanistic interventional research. A systematic search in electronic databases (i.e., PubMed, Scopus, PsycINFO, Web Science) performed January February 2021 English articles published between 1990 2020 reporting mental health measures. Data included were retrieved organized according RDoC bio-behavioral matrix its constituent six main domains, namely: positive valence systems, negative cognitive social processes, sensorimotor arousal regulatory systems. The preponderance research with has differentially reported beneficial system, process domains. data support both short-term (23 assessments) long-term (15 While 12 extracted outcome measures use is associated increases "fear" construct systems domain, 19 findings show no significant construct, seven parameters lowered levels "sustained threat" long term. Thirty-four revealed alterations systems' namely, "perception understanding self," "social communications" enhancements others" "affiliation attachment". majority related domain dyscognitive effects. There have been relatively few outcomes remaining Moreover, dashboard characterization suggests reward, threat, arousal, general Psilocybin possesses a multi-domain effectiveness. field would benefit highly rigorous proof-of-mechanism assess using framework. combined effect psychosocial interventions priority therapeutic vista.

Язык: Английский

Annual Research Review: The contributions of the RDoC research framework on understanding the neurodevelopmental origins, progression and treatment of mental illnesses DOI
Jennifer Pacheco, Marjorie A. Garvey,

Christopher S. Sarampote

и другие.

Journal of Child Psychology and Psychiatry, Год журнала: 2022, Номер 63(4), С. 360 - 376

Опубликована: Янв. 3, 2022

The National Institute of Mental Health (NIMH) proposed the Research Domain Criteria (RDoC) initiative as an alternate way to organize research mental illnesses, by looking at dimensions functioning rather than being tied categorical diagnoses. This paper briefly discusses motivation for and organization RDoC, then explores NIMH portfolio recent work monitor utility progress that RDoC has afforded developmental research. To examine how influenced over last decade, we employed a natural language processing algorithm identify number science grants classified incorporating approach. Additional analyses temporal trends in funded RDoC‐relevant grants, publications citations, training opportunities. Reflecting on focus grant applications, highlight examples from Attention‐Deficit Hyperactivity Disorder (ADHD), childhood irritability, Autism Spectrum (ASD). Lastly, consider dimensional transdiagnostic approaches emphasized have facilitated personalized intervention heterogeneous disorders preventive/early interventions targeting emergent or subthreshold psychopathology.

Язык: Английский

Процитировано

71
Glucagon-like peptide 1 agonist and effects on reward behaviour: A systematic review DOI Creative Commons
Sebastian Badulescu, Aniqa Tabassum, Gia Han Le

и другие.

Physiology & Behavior, Год журнала: 2024, Номер 283, С. 114622 - 114622

Опубликована: Июнь 28, 2024

The roles of metabolic signals, including Glucagon-like peptide 1 (GLP-1), have been implicated in multiple domains outside regulation. There is a growing interest repurposing receptor agonists (GLP-1RAs) as therapeutics for motivation and reward-related behavioural disturbances. Herein, we aim to systematically review the extant evidence on potential effects GLP-1RAs reward system.

Язык: Английский

Процитировано

8
Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma DOI Creative Commons
Grant L. Iverson, Andrew J. Gardner, Sandy R. Shultz

и другие.

Brain, Год журнала: 2019, Номер 142(12), С. 3672 - 3693

Опубликована: Сен. 23, 2019

In the 20th century, chronic traumatic encephalopathy (CTE) was conceptualized as a neurological disorder affecting some active and retired boxers who had tremendous exposure to neurotrauma. recent years, two research groups in USA have led field asserted definitively that CTE is delayed-onset progressive neurodegenerative disease, with symptoms appearing midlife or decades after exposure. Between 2005 2012 autopsy cases of former American football players described neuropathology attributed broad diverse. This pathology, resulting from multiple causes, aggregated referred to, toto, pathology 'characteristic' CTE. Preliminary consensus criteria for defining were forged 2015 published 2016. Most macroscopic microscopic neuropathological findings characteristic CTE, studies before 2016, not included new pathology. past few there has been steadily emerging evidence unique may be unique. individuals no known participation collision contact sports repetitive reported substance abuse, temporal lobe epilepsy, amyotrophic lateral sclerosis, system atrophy, other diseases. Moreover, throughout history, clinical being progressive, now might individuals. Considering current state knowledge, including absence series validated sensitive specific biomarkers, inexorably those experienced

Язык: Английский

Процитировано

69
The effect of ketamine on anhedonia: improvements in dimensions of anticipatory, consummatory, and motivation-related reward deficits DOI

Danica Nogo,

Ashitija Jasrai,

Haeun Kim

и другие.

Psychopharmacology, Год журнала: 2022, Номер 239(7), С. 2011 - 2039

Опубликована: Март 15, 2022

Язык: Английский

Процитировано

32
IUPHAR – invited review - Ibogaine – A legacy within the current renaissance of psychedelic therapy DOI Creative Commons
Deborah C. Mash

Pharmacological Research, Год журнала: 2023, Номер 190, С. 106620 - 106620

Опубликована: Март 11, 2023

Ibogaine is a powerful psychoactive substance that not only alters perception, mood and affect, but also stops addictive behaviors. has very long history of ethnobotanical use in low doses to combat fatigue, hunger thirst and, high as sacrament African ritual contexts. In the 1960's, American European self-help groups provided public testimonials single dose ibogaine alleviated drug craving, opioid withdrawal symptoms, prevented relapse for weeks, months sometimes years. rapidly demethylated by first-pass metabolism long-acting metabolite noribogaine. its interact with two or more CNS targets simultaneously both drugs have demonstrated predictive validity animal models addiction. Online forums endorse benefits an "addiction interrupter" present-day estimates suggest than ten thousand people sought treatment countries where unregulated. Open label pilot studies ibogaine-assisted detoxification shown positive benefit treating Ibogaine, granted regulatory approval human testing Phase 1/2a clinical trial, joins current landscape psychedelic medicines development.

Язык: Английский

Процитировано

16
Inter-relationships of depressive and anxiety symptoms with suicidality among adolescents: A network perspective DOI
Hong Cai,

Ines H.I. Chow,

Si-Man Lei

и другие.

Journal of Affective Disorders, Год журнала: 2022, Номер 324, С. 480 - 488

Опубликована: Дек. 28, 2022

Язык: Английский

Процитировано

23
Internet addiction and residual depressive symptoms among clinically stable adolescents with major psychiatric disorders during the COVID-19 pandemic: a network analysis perspective DOI Creative Commons
Hong Cai, Yan-Jie Zhao, Fan He

и другие.

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Июнь 3, 2023

Abstract To assess the inter-relationships between residual depressive symptoms (RDS) and Internet addiction (IA) using network analysis among clinically stable adolescents with major psychiatric disorders during COVID-19 pandemic. RDS IA were assessed Patient Health Questionnaire-9 (PHQ-9) Addiction Test (IAT), respectively. Central bridge in model examined. A total of 1,454 met study criteria included analyses. The prevalence was 31.2% (95% CI: 28.8%-33.6%). In analysis, nodes IAT15 (“Preoccupation Internet”), PHQ2 (“Sad mood”), PHQ1 (“Anhedonia”) most central IA-RDS model. Bridge IAT10 (“Sooth disturbing about your use”), PHQ9 (“Suicide ideation”), IAT3 (“Prefer excitement online to time others”). Additionally, mood”) main node linking “Anhedonia” other clusters. common Core identified this could be prioritized as targets for prevention treatment population.

Язык: Английский

Процитировано

14
Effects of attention to negative information on the bidirectional relationship between fear of missing out (FoMO), depression and smartphone addiction among secondary school students: Evidence from a two-wave moderation network analysis DOI
Yanqiang Tao, Qihui Tang, Xinyuan Zou

и другие.

Computers in Human Behavior, Год журнала: 2023, Номер 148, С. 107920 - 107920

Опубликована: Авг. 16, 2023

Язык: Английский

Процитировано

13
From Reward to Anhedonia-Dopamine Function in the Global Mental Health Context DOI Creative Commons
Birgitta Dresp

Biomedicines, Год журнала: 2023, Номер 11(9), С. 2469 - 2469

Опубликована: Сен. 6, 2023

When “hijacked” by compulsive behaviors that affect the reward and stress centers of brain, functional changes in dopamine circuitry occur as consequence pathological brain adaptation. As a correlate mental health, has central role behavioral regulation from healthy reward-seeking to adaptation response adversity. This narrative review offers spotlight view transition function, under control dopamine, progressive deregulation this function interactions with other circuits, producing what may be called an anti-reward state. How such is linked specific health-relevant then explained pandemic-related adversities stresses they engendered. The long lockdown periods where people social isolation had rely on drink, food, digital rewards via internet seen major triggers motivation behavior worldwide. dopamine-mediated discussed. It argued that, when pushed fate circumstance into physiological state anti-reward, human health affected, depending individual vulnerabilities. A unified conceptual account places at centre current global context proposed.

Язык: Английский

Процитировано

13
Microbiome and substances of abuse DOI

M. Salavrakos,

Sophie Leclercq, Philippe de Timary

и другие.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2020, Номер 105, С. 110113 - 110113

Опубликована: Сен. 22, 2020

Язык: Английский

Процитировано

33