Prescriptions of antidepressants and anxiolytics in France 2012–2022 and changes with the COVID-19 pandemic: interrupted time series analysis

BMJ Mental Health, Год журнала: 2024, Номер 27(1), С. e301026 - e301026

Опубликована: Янв. 1, 2024

Background Depression and anxiety have increased in prevalence since the start of COVID-19 pandemic. Objective To evaluate consumption antidepressants anxiolytics from 2012 to 2022 pandemic’s potential impact France. Methods We conducted an interrupted time series analysis routine drug sales data (Medic'AM) all French outpatient pharmacies 2022. investigated trends defined daily doses sold per 1000 inhabitants (DDD/TID) related expenditures before after pandemic onset relation with stringency mitigation measures. Analyses were performed descriptively using segmented linear regression, autoregressive integrated moving average models. Findings From 2019, overall monthly antidepressant (+0.02 DDD/TID) while anxiolytic decreased (−0.07 DDD/TID). With onset, there was a relevant persisting trend increase (+0.20 DDD/TID month) for overall, estimated excess 112.6 May 2020 until December Anxiolytic elevated February throughout but returned expected levels by 2022, 33.8 DDD/TID. There no evident association between or sales. Conclusions This study showed protracted increases temporary. Clinical implications provide evidence that may had long-lasting consequences on treatment depression disorders, requiring further actions researchers policy-makers address this public mental health crisis.

Язык: Английский

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ADHD medicine consumption in Europe after COVID-19: catch-up or trend change?

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 9, 2024

Abstract Background Although the COVID-19 pandemic and its implications have been associated with mental health services utilization medication consumption, there is no longitudinal study on long-term impact ADHD use trends. Methods This examines European consumption in 2020 to 2022 compared predicted assuming persistence of pre-pandemic Predictions are calculated using Seasonal Autoregressive Integrated Moving Average (SARIMA) models. Results While sales recorded a drop 2020, they returned level 2021, even slightly exceeding it. In 2022, we found clear exceedance by 16.4% average at country level. Furthermore, increase growth post-pandemic period (2021–2022) (2014–2019) was significant 26 28 countries under consideration. Conclusion There strong evidence trend change medicine throughout Europe after pandemic.

Язык: Английский

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Utilization of antidepressants, anxiolytics, and hypnotics during the COVID-19 pandemic

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 4, 2024

Abstract Since the onset of COVID-19 pandemic, there have been concerns over mental health impact COVID-19. This is a review utilization antidepressants, anxiolytics, and hypnotics since pandemic was declared on March 11th 2020. A number reports so far based large prescription databases for administrative use at national or regional level, but mainly in high-income countries. We found studies reporting increased rates during 2020, which has interpreted as hoarding such medications. In following months, most antidepressant did not display clear pattern change compared with prepandemic trends. later phases small increases higher than predicted rates, consistent finding, especially youth. countries, were increasing trends antidepressants also before needs to be considered when estimating whereas anxiolytics hypnotics, patterns prescriptions more varying. Overall, after 2020 we could find any distinct changes pandemic. Most contain information about prevalence indicated psychiatric disorders studied populations. More are needed long-term effects COVID-19, particularly regarding antidepressants. Research relating major depression anxiety would promote better understanding how well reflect population.

Язык: Английский

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Sales trends of psychotropic drugs in the COVID-19 pandemic: A national database study in Brazil

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Март 17, 2023

Background: The social restrictions among coronavirus disease 2019 (COVID-19) pandemic have posed a thoughtful risk to mental health and implications in the use of drugs, including antidepressants, anxiolytics other psychotropics. Objective: This study analyzed sales data psychotropics prescribed Brazil, order verify change consumption trends these drugs during COVID-19 pandemic. Methods: interrupted time-series psychotropic data, between January 2014 July 2021, using National System Controlled Products Management from Brazilian Health Regulatory Agency. monthly mean DDDs per 1,000 inhabitants day was evaluated by analysis variance (ANOVA) followed Dunnett Multiple Comparisons Test. changes studied were Joinpoint regression. Results: During period studied, clonazepam, alprazolam, zolpidem escitalopram most sold Brazil. According regression, an upward trend observed pregabalin, escitalopram, lithium, desvenlafaxine, citalopram, buproprion amitriptyline. An increase noted throughout period, with maximum (2.61 DDDs) occurring April downward that accompanied drop number deaths. Conclusions: sales, mainly antidepressants pandemic, draws attention issues related population on need for greater monitoring dispensing drugs.

Язык: Английский

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Global insight into the occurrence, treatment technologies and ecological risk of emerging contaminants in sanitary sewers: Effects of the SARS-CoV-2 coronavirus pandemic

The Science of The Total Environment, Год журнала: 2024, Номер 921, С. 171075 - 171075

Опубликована: Фев. 23, 2024

Язык: Английский

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Socioeconomic trends in anxiolytic, hypnotic, and sedative use among secondary school students in Spain from 2010 to 2021: a repeated cross-sectional design

International Journal for Equity in Health, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 19, 2025

The increasing use of anxiolytics, hypnotics, and sedatives (AHS) among adolescents is a growing public health concern. Social determinants such as gender or socioeconomic status have significant influence on consumption levels. However, whether trends in adolescent AHS show disparities unknown. aim this study to examine the inequalities secondary school students' Spain from 2010 2021. A repeated cross-sectional analysis was conducted using data Survey Drug Use Secondary Education (n = 192,656), targeting students aged 14–18 years during 2010–2021. Gender-specific prevalences were calculated according educational occupational mother, father, both parents. Chi-squared tests assessed statistical significance observed social gradients. Relative Index Inequality (RII) Slope (SII) with 95% confidence intervals used measure inequality magnitudes. Consumption examined through prevalence ratios (PR) derived age-adjusted robust variance Poisson models. Statistically identified girls, which increased over time. These particularly pronounced when considering maternal level (e.g. 2021: 21.5% vs. 16.3%; RII2021 1.37 [1.16–1.62]) paternal 23.2% 16.5%). Trends showed increase all groups male female parents primary education: PR2021 1.74 [1.23–2.47] 1.83 [1.49–2.25], respectively). findings highlight necessity for developing equity-focused policies addressing use, especially disadvantaged students. Further research needed explore an intersectional perspective.

Язык: Английский

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Fluctuations in dispensed out-patient psychotropic medication prescriptions during the COVID-19 pandemic in The Netherlands

BJPsych Open, Год журнала: 2025, Номер 11(2)

Опубликована: Март 1, 2025

The COVID-19 pandemic and lockdowns had a significant impact on mental well-being (mental) healthcare systems globally. To describe trends dynamics of out-patient prescribing psychotropic medications during the in Netherlands. Dispensed medication prescriptions from March 2020 to 2022 were retrieved national registry data. Numbers total incident dispensed defined daily doses (DDDs) identified for six groups. Overall pandemic-related changes analysed using interrupted time-series analyses. Lockdown-related described monthly risk ratios. No overall detected, except alcohol addiction medication, which pre-pandemic decline DDDs levelled off pandemic: +10 per week (95% CI 7-11, P ≤ 0.001) +111 56-165, = 0.001). Monthly showed transient increases all groups second third lockdown periods. There decreases antidepressant opioid first (average ratios: 0.87 0.88 respectively), attention-deficit hyperactivity disorder benzodiazepine elevated end 1.40, 1.12 1.17, respectively). These findings raise concerns regarding possible over- under-prescribing pandemic. Further understanding specific factors driving these is necessary help prepare future health(care) challenges.

Язык: Английский

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Did the COVID-19 pandemic influence the use of psychotropic medications by university students and LGBTQIAPN+? A Brazilian multicenter study

Cadernos de Saúde Pública, Год журнала: 2025, Номер 41(3)

Опубликована: Янв. 1, 2025

Abstract: The COVID-19 pandemic may have had an impact on the mental health of university students and, consequently, led to initiation psychotropic medications or increase its use. This study aimed assess prevalence use among and evaluate association such medicine with who belong minority groups. is a cross-sectional study, in which all enrolled undergraduate courses at eight Brazilian public universities were invited answer online self-administered questionnaire. data collection was conducted from October 2021 February 2022. outcome explanatory variables groups, as female, black, mixed-race, other skin colors, LGBTQIAPN+ individuals. descriptively analyzed Pearson’s chi-squared test multinomial logistic regression performed. A total 8,650 participated 25.7% reported using 30 days prior completing It observed that students, female (OR = 1.8; 95%CI: 1.41-2.20) non-heterosexual 1.5; 1.23-1.80) higher chances during pandemic. found began groups observed.

Язык: Английский

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Benzodiazepine Interference with Fertility and Embryo Development: A Preliminary Survey in the Sea Urchin Paracentrotus lividus

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 1969 - 1969

Опубликована: Фев. 6, 2024

Psychotropic drugs and benzodiazepines are nowadays among the primary substances of abuse. This results in a large constant release into aquatic environments where they have potentially harmful effects on non-target organisms and, eventually, human health. In last decades, evidence has been collected possible interference with reproductive processes, but data few incomplete. this study, negative influence delorazepam fertilization embryo development tested Paracentrotus lividus, key model organism studies reproduction embryonic development. Sperm, eggs, or fertilized eggs exposed to at three concentrations: 1 μg/L (environmentally realistic), 5 μg/L, 10 μg/L. Results indicate that reduces fertilizing capacity male female gametes interferes Exposure causes anatomical anomalies plutei, accelerates/delays development, alters presence distribution glycoconjugates such as N-Acetyl-glucosamine, α-linked fucose, mannose both morulae plutei. These should attract attention fitness species pave way for further investigation may exert fertility. The environment raises concerns about well-being species. Additionally, it prompts worries regarding potential impacts fertility due excessive use anxiolytics.

Язык: Английский

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Prolonged increase in psychotropic drug use among young women following the COVID-19 pandemic: a French nationwide retrospective study

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 2, 2024

Abstract Background The COVID-19 pandemic has had a significant impact on mental health, with evidence suggesting an enduring health crisis. Studies worldwide observed increased usage of antidepressants, anxiolytics, and hypnotics during the pandemic, notably among young people women. However, few studies tracked consumption post-2021. Our study aimed to fill this gap by investigating whether surge in number psychotropic drug consumers France persisted 2 years after first lockdown, particularly focusing age gender differences. Methods We conducted national retrospective observational based French insurance database. retrieved all prescriptions hypnotics, antidepressants dispensed pharmacies for period 2015–2022. performed interrupted time series analyses Poisson models five classes (12–18; 19–25; 26–50; 51–75; 76 more) assess trend before induced change after. Results In overall population, remained constant while it decreased anxiolytics hypnotics. Despite global trend, long-term increase was 12–18 19–25 groups three classes. Moreover, these classes, increases were more pronounced women than men, except where trends similar. Conclusions using continues showing prolonged effect health. This is striking adolescents adults confirming devastating their

Язык: Английский

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