Journal of Personalized Medicine,
Год журнала:
2025,
Номер
15(2), С. 62 - 62
Опубликована: Фев. 7, 2025
Background:
Bipolar
disorder
(BD)
is
a
chronic
condition
associated
with
treatment
resistance,
cognitive
decline,
structural
brain
changes,
and
an
approximately
13-year
reduction
in
life
expectancy
compared
to
the
general
population.
Depression
BD
substantially
impairs
quality
of
life,
while
neuroinflammation
excitotoxicity
are
thought
contribute
recurrence
mood
episodes
disease
progression.
Brain-derived
neurotrophic
factor
(BDNF)
plays
key
role
neuronal
growth
function,
its
dysregulation
being
linked
various
psychiatric
disorders.
This
study
extension
previously
published
clinical
trial
was
conducted
assess
effects
three
BDNF
BDNF-AS
gene
polymorphisms
(rs1519480,
rs6265,
rs10835210)
on
outcomes
serum
levels
patients
treatment-resistant
bipolar
depression
(TRBDD)
over
eight-week
period.
Methods:
included
41
participants
from
randomized
trial,
all
whom
had
available
samples
genotype
data.
The
participants,
aged
21
65,
were
diagnosed
disorder,
assessed
using
Maudsley
Staging
Method.
Participants
randomly
assigned
receive
either
escitalopram
plus
placebo
(ESC+PBO)
or
celecoxib
(ESC+CBX)
8-week
Statistical
analyses
mixed
ANOVA
chi-square
tests
compare
minor
allele
carrier
status
SNPs
response
remission
rates.
Results:
Non-carriers
rs6265
A
(p
=
0.005)
carriers
rs10835210
0.007)
showed
significantly
higher
adjunctive
alone.
Additionally,
rates
after
both
non-carriers
across
However,
notably
rs1519480
G
allele,
as
well
allele.
Conclusions:
suggests
that
genetic
variations
genes
influence
disorder.
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(4)
Опубликована: Апрель 1, 2025
ABSTRACT
This
study
investigates
the
phytochemical
composition
and
biopharmacological
potential
of
three
Hypericum
species
(
H.
scabrum
,
lysimachioides
uniglandulosum
)
from
Turkey.
Aqueous
hydroalcoholic
extracts
were
analyzed
for
their
total
phenolic
content
(TPC),
flavonoid
(TFC),
individual
components
(by
UHPLC–HRMS
technique).
Antioxidant
activities
investigated
by
DPPH,
ABTS,
CUPRAC,
FRAP,
phosphomolybdenum,
metal
chelating
assays.
The
inhibition
effects
tested
on
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
tyrosinase,
amylase,
glucosidase
examined.
One
hundred
compounds
identified
in
chemical
composition,
specific
genus
such
as
hyperoside,
hypericin,
pseudohypericin,
detected.
highest
TPC
was
detected
ethanol/water
extract
with
69.21
mg
GAE/g.
Furthermore,
showed
strongest
free
radical
reducing
effect.
more
active
than
water
extracts.
Neuroprotective
assessments
indicated
downregulation
COX‐2
NOS‐2
genes
LPS‐stimulated
mouse
cortex
models,
alongside
modulation
SERT
NET
expression,
suggesting
reduced
neuroinflammation
enhanced
neurotransmitter
release.
Molecular
docking
dynamics
analyses
highlighted
strong
binding
interactions,
especially
NET_hyperoside
NET_myricitrin
complexes.
results
indicate
significant
therapeutic
these
extracts,
supporting
development
natural
agents
against
oxidative
stress,
neuroinflammation,
related
neurodegenerative
diseases.
ACS Central Science,
Год журнала:
2024,
Номер
10(5), С. 1105 - 1114
Опубликована: Апрель 25, 2024
Cyclooxygenase-2
(COX-2)
is
an
enzyme
that
plays
a
pivotal
role
in
peripheral
inflammation
and
pain
via
the
prostaglandin
pathway.
In
central
nervous
system
(CNS),
COX-2
implicated
neurodegenerative
psychiatric
disorders
as
potential
therapeutic
target
biomarker.
However,
clinical
studies
with
have
yielded
inconsistent
results,
partly
due
to
limited
mechanistic
understanding
of
how
activity
relates
CNS
pathology.
Therefore,
developing
positron
emission
tomography
(PET)
radiotracers
for
human
neuroimaging
interest.
This
study
introduces
[11C]BRD1158,
which
potent
uniquely
fast-binding,
selective
PET
radiotracer.
[11C]BRD1158
was
developed
by
prioritizing
potency
at
COX-2,
isoform
selectivity
over
COX-1,
fast
binding
kinetics,
free
fraction
brain.
Evaluated
through
vivo
rodent
models
overexpression,
demonstrated
high
brain
uptake,
target-engagement,
functional
reversibility,
excellent
specific
binding,
advantageous
imaging
applications.
Lastly,
post-mortem
samples
from
Huntington's
disease
(HD)
patients
preclinical
HD
mouse
showed
levels
were
elevated
specifically
disease-affected
regions,
primarily
increased
expression
microglia.
These
findings
indicate
holds
promise
novel
marker
onset
progression,
one
many
applications
PET.
Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(12)
Опубликована: Дек. 24, 2024
The
coexistence
of
anxiety
or
depression
with
coronary
heart
disease
(CHD)
is
a
significant
clinical
challenge
in
cardiovascular
medicine.
Recent
studies
have
indicated
that
hypothalamic-pituitary-adrenal
(HPA)
axis
activity
could
be
promising
focus
understanding
and
addressing
the
development
treatments
for
comorbid
CHD
depression.
HPA
helps
to
regulate
levels
inflammatory
factors,
thereby
reducing
oxidative
stress
damage,
promoting
platelet
activation,
stabilizing
gut
microbiota,
which
enhance
survival
regeneration
neurons,
endothelial
cells,
other
cell
types,
leading
neuroprotective
cardioprotective
benefits.
This
review
addresses
relevance
nervous
systems,
as
well
latest
research
advancements
regarding
its
mechanisms
action.
discussion
includes
detailed
function
regulating
processes
mentioned.
Above
all,
it
summarizes
therapeutic
potential
biomarker
atherosclerotic
combined
