Child and Adolescent Social Work Journal, Год журнала: 2024, Номер unknown
Опубликована: Авг. 26, 2024
Язык: Английский
Ageing & Longevity, Год журнала: 2025, Номер 1.2025, С. 6 - 21
Опубликована: Янв. 17, 2025
Neuroglia of the central nervous system, represented by astroglia, oligodendroglia and microglia, are fundamental for life-long support homeostasis, plasticity defence neural tissue. In particular neuroglial cells contribute to cognitive reserve, which defines neurological outcome both physiological pathological ageing. Physiological ageing is accompanied with structural functional decline neuroglia. particular, astrocytes undergo morphological atrophy asthenia compromises their vital functions such as glutamate clearance, K+ buffering synaptic support. Old oligodendrocytes lose myelination capacity, results in thinning myelin sheath white matter. Finally, associated accumulation dystrophic microglia limits neuroprotection. Age-dependent impedes contributes impairment, increases vulnerability system neurodegeneration. Life style changes positively impact on structure function this improving longevity. Keywords: ageing; longevity; neuroglia, oligodendroglia; oligodendroglial precursor cells;
Язык: Английский
Процитировано
3
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Март 18, 2024
Abstract The aim to examine the link between diabetes distress and depression in individuals with diabetes, assess mediating role of psychological resilience this relationship, analyses if these relationships differ Type 1 2 diabetes. study utilized a cross-sectional design. A total 181 (age 33–72 years, mean = 54.76 SD 9.05 years) diagnosed who were receiving treatment from State Specialist Hospitals Okitipupa selected for using convenient sampling technique. data analysed Pearson Multiple correlation multi-group mediation analysis. carried out Smartpls IBM/SPSS Version 28.0. results revealed significant positive (r .80, p < .05), suggesting that higher levels associated increased scores. Additionally, partially mediated relationship ( b − 0.10, signifying played crucial mitigating impact on depression. Furthermore, analysis was conducted explore potential differences subgroups. found be more pronounced subgroup (difference 0.345, while negatively stronger 0.404, .05) compared subgroup. There is an intricate linkage distress, resilience, depression, emphasizing differential roles insights gleaned underscore importance considering type when designing interventions support mechanisms are also suffering By advancing our understanding dynamics, we can strive effective personalized approaches improve overall well-being those living
Язык: Английский
Процитировано
9
Molecular Psychiatry, Год журнала: 2024, Номер unknown
Опубликована: Июль 2, 2024
Abstract The concept of cognitive reserve was born to account for the disjunction between objective extent brain damage in pathology and its clinical intellectual outcome. comprises structural (brain reserve) functional maintenance, resilience, compensation) aspects nervous tissue reflecting exposome-driven life-long plasticity, which defines ability withstand aging pathology. mechanistic background this primarily focused on adaptive changes neurones neuronal networks. We present arguments favoring more inclusive view, positing that neuroglia are fundamental defining through homeostatic, neuroprotective, neurodegenerative mechanisms. Neuroglia critical shaping synaptically connected circuits as well connectome thus reserve. Neuroglial homeostatic protective physiological responses define maintenance while regenerative capabilities compensation Targeting may represent an untrodden path prolonging longevity.
Язык: Английский
Процитировано
7
BMC Psychology, Год журнала: 2025, Номер 13(1)
Опубликована: Март 12, 2025
Life events are important risk factors for negative psychology such as depression and anxiety. However, individuals who experienced the same life might not necessarily develop mental health problems. Some inherent psychological qualities among may determine their status under events. Physical activity is beneficial to physical health. What combined effect of on individual anxiety, whether it can alleviate induced by events, at present, there no relevant research report. To systematically analyze college students related mediating mechanism. Guided a series hypotheses, study conducted cross-sectional survey level, event experience, vulnerability, anxiety 3552 Chinese students. On basis hierarchical comparison, correlation analysis, logistics regression analysis structural equation model method were further used explore relationship between variables, test hypotheses in sequence. was negatively but positively correlated with depression; Psychological vulnerability played partial role health, accounting 22.17% 23.42% total effect, respectively; had an interaction completely role, 91.86% effect; could significantly reverse poor effectively adverse effects vulnerability.
Язык: Английский
Процитировано
0
SAGE Open Medicine, Год журнала: 2024, Номер 12
Опубликована: Янв. 1, 2024
Objectives: Promoting resilience and embracing healthy coping strategies can effectively assist nursing students in managing stress enhancing their welfare. Nonetheless, a comprehensive understanding of the factors influencing well-being resilience, pivotal for both academic accomplishments future career longevity, remains incomplete. Methods: A cross-sectional descriptive correlational design was adopted this study. Participants comprised enrolled pre-registration programs at undergraduate graduate levels. The World Health Organization-5 Well-Being Index 10-item Connor-Davidson Resilience Scale were utilized to assess psychological respectively. Results: study involved 175 university selected through convenience sampling. On Scale, average score 25.5, with scoring an 25.4 26.3, Nevertheless, two groups had no statistically significant difference ( p = 0.526). Regarding perceived well-being, 16.1, noticeable distinction between undergraduates postgraduates 0.858). Notably, bivariate analysis revealed moderate positive correlation self-reported rp 0.281, 0.001). Moreover, senior exhibited significantly higher scores on scale than junior (17.0 vs 15.1, 0.010). Multivariable regression also identified that represents consistent means predicting (regression coefficient B 0.22, < Conclusions: outcomes indicate university-based who exhibit levels have more perceptions well-being. postgraduate students.
Язык: Английский
Процитировано
4
Neural Regeneration Research, Год журнала: 2024, Номер 20(1), С. 159 - 173
Опубликована: Апрель 3, 2024
Brain-derived neurotrophic factor is a key in stress adaptation and avoidance of social behavioral response. Recent studies have shown that brain-derived expression stressed mice brain region–specific, particularly involving the corticolimbic system, including ventral tegmental area, nucleus accumbens, prefrontal cortex, amygdala, hippocampus. Determining how participates processing different regions will deepen our understanding psychopathology. In this review, we discuss regulation stress-sensitive closely related to pathophysiology depression. We focused on associated molecular pathways neural circuits, with special attention factor–tropomyosin receptor kinase B signaling pathway area–nucleus accumbens dopamine circuit. determined stress-induced alterations levels are likely nature, severity, duration stress, especially above-mentioned system. Therefore, BDNF might be biological indicator regulating stress-related processes various regions.
Язык: Английский
Процитировано
4
Frontiers in Psychology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 7, 2024
Background Latin American youth have a high prevalence of mental health disorders and face major socioeconomic public safety problems. This study assesses the association between stressful life events (SLEs) depression, anxiety, quality among adolescents young adults from deprived neighbourhoods America. Methods The sample consisted 2,402 participants, (15–16 years) (20–24 years), Bogotá (Colombia), Buenos Aires (Argentina), Lima (Peru), assessed in 2021–2022 recruited education community settings social media. We evaluated most frequent recent distant SLEs (occurred previous year more than ago, respectively), relationship severity depression (PHQ-8), anxiety (GAD-7), (MANSA), we tested for differences by gender age group. Results common were related to issues financial distress. Accidents school suspensions men, sexual harassment bullying women. Every additional reported SLE increased odds mild, moderate, severe (18, 17, 25%, respectively) (10, 21%, symptoms. Similar trends found with (8, 9, 11% symptoms, (9, 11, 12%, respectively). Furthermore, higher number associated lower ( β = −0.05, p < 0.001, 95% CI [−0.06, −0.04] −0.04, [−0.05, −0.03], distress seems stronger one SLEs, may impact on adolescents’ compared adults. Conclusion Both are life. Policies programmes should aim enhance safety, as well improve individual, family, protective factors that could mitigate effect youth.
Язык: Английский
Процитировано
4
Frontiers in Education, Год журнала: 2025, Номер 9
Опубликована: Янв. 16, 2025
Introduction Emerging adulthood is a vulnerable period and can be crisis for many youth, leading to serious mental health problems. Medical students are especially due their high exposure stressors, requiring enhanced resilience cope with academic challenges. This study measured the effectiveness of near-peer mentoring program in terms resilience. Methods A non-randomised controlled trial was conducted at Semmelweis University involving 133 medical students. The case group ( n = 94) comprised who participated as mentors or mentees. control 39) did not participate mentoring. Data collected two points, 5 months apart, semester’s start (August 2022) end (February 2023). Self-report measures included sociodemographics, (Connor-Davidson Resilience Scale), depression (Depression Anxiety Stress Scale). Statistical analysis involved descriptive statistics mixed linear models repeated-measures ANOVA. Results showed significant increase compared F (1, 129) 5.578, p 0.020), no main effect time. There interaction between intervention time on (1.000, 129.000) 4.915, 0.028). Depression scores difference but 4.725, 0.032) 4.018, 0.047). Discussion effectively increased helped maintain health, contributing developing skilled healthcare professionals—where remains key strength 21st-century doctors.
Язык: Английский
Процитировано
0
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(5), С. 1516 - 1516
Опубликована: Фев. 24, 2025
Background: This research aimed to investigate the mediating and moderating effects of psychological resilience (PR) on association between childhood trauma (CT) development depression. Methods: study included 94 cases who consecutively applied outpatient psychiatry clinic Rize Recep Tayyip Erdoğan University Training Research Hospital in Turkey 1 June 2023 December were diagnosed with Major Depressive Disorder (MDD). In addition, 83 healthy individuals (control group) also included. Participants administered Hamilton Depression Rating Scale (HDRS), Resilience for Adults (RSA), Childhood Trauma Questionnaire (CTQ). Results: context this research, effect PR CT depression was investigated. When examining role depression, it found that statistically significantly influenced disease severity directly (B = 0.158, SE 0.0398, z 3.98, p < 0.001, 95% CI [0.0759, 0.232]), while indirectly through 0.193, 0.028, 6.88, [0.1343, 0.244]). It revealed mediated depressive symptoms partially. Conclusions: demonstrates has a relationship MDD. These results provide new contributions existing literature. Interventions increase may positively contribute treatment patients MDD have suffered from CT.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 19, 2025
Empathy, the ability to understand and respond others' emotional experiences, is often regarded as a universally positive trait. However, its role in psychological adjustment following adversity more complex. The current study examined relationships between empathy - measured globally through (compassionate concern) negative (callousness) dimensions three outcomes of stress or trauma: depressive symptoms, resilience, posttraumatic growth (PTG). College students (N = 403) completed online surveys assessing these variables, with controls for age, sex, personality traits. Hierarchical regression analyses showed that global were positively associated PTG, indicating empathy's fostering personal relational growth. also predicted reflecting potential heighten vulnerability distress. Negative was inversely related PTG but unrelated symptoms resilience. Resilience demonstrated weaker links empathy, instead aligning closely traits like extraversion conscientiousness. These findings highlight dual impact, where it can contribute while increasing susceptibility Future research should explore cognitive affective components develop strategies minimize effects enhancing adaptive PTG.
Язык: Английский
Процитировано
0