Pharmacological Research,
Год журнала:
2024,
Номер
206, С. 107300 - 107300
Опубликована: Июль 9, 2024
Depression
is
a
serious
global
mental
disorder.
Numerous
studies
have
found
that
depression
may
be
closely
related
to
decreased
neurogenesis,
neuroinflammation,
neurotransmitter
imbalance,
and
synaptic
plasticity
dysfunction.
The
pathogenesis
of
complex
involves
multiple
signal
transduction
pathways
molecular
changes.
PI3K/AKT
pathway
an
essential
signaling
in
neurons,
which
widely
expressed
emotion-related
regions
the
brain.
Therefore,
play
moderating
role
mood
disorders.
However,
mechanism
not
been
fully
described.
This
review
systematically
summarized
discussed
its
potential
treatment
depression.
will
help
development
antidepressants.
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 9, 2024
Coronary
heart
disease
(CHD),
a
cardiovascular
condition
that
poses
significant
threat
to
human
health
and
life,
has
imposed
substantial
economic
burden
on
the
world.
However,
in
contrast
conventional
risk
factors,
depression
emerges
as
novel
independent
factor
for
CHD.
This
impacts
onset
progression
of
CHD
elevates
adverse
prognostic
events
those
already
affected
by
As
result,
garnered
increasing
global
attention.
Despite
this
growing
awareness,
specific
mechanisms
through
which
contributes
development
remain
unclear.
Existing
research
suggests
primarily
influences
inflammatory
response,
Hypothalamic-pituitary-adrenocortical
axis
(HPA)
Autonomic
Nervous
System
(ANS)
dysfunction,
platelet
activation,
endothelial
lipid
metabolism
disorders,
genetics,
all
play
pivotal
roles
development.
Furthermore,
effectiveness
safety
antidepressant
treatment
patients
with
comorbid
its
potential
impact
prognosis
have
become
subjects
controversy.
Further
investigation
is
warranted
address
these
unresolved
questions.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 184 - 184
Опубликована: Янв. 15, 2024
Perimenopausal
depression,
occurring
shortly
before
or
after
menopause,
is
characterized
by
symptoms
such
as
emotional
anxiety,
and
stress,
often
accompanied
endocrine
dysfunction,
particularly
hypogonadism
senescence.
Current
treatments
for
perimenopausal
depression
primarily
provide
symptomatic
relief
but
come
with
undesirable
side
effects.
The
development
of
agents
targeting
the
specific
pathologies
has
been
relatively
slow.
erratic
fluctuations
in
estrogen
progesterone
levels
during
stage
expose
women
to
risk
developing
perimenopausal-associated
depression.
These
hormonal
changes
trigger
production
proinflammatory
mediators
induce
oxidative
leading
progressive
neuronal
damage.
This
review
serves
a
comprehensive
overview
underlying
mechanisms
contributing
It
aims
shed
light
on
complex
relationship
between
hormones,
neurotransmitters,
brain-derived
neurotrophic
factors,
chronic
inflammation,
By
summarizing
intricate
interplay
fluctuations,
neurotransmitter
activity,
this
stimulate
further
research
field.
hope
that
an
increased
understanding
these
will
pave
way
more
effective
therapeutic
targets,
ultimately
reducing
menopausal
betterment
psychological
wellbeing.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 614 - 614
Опубликована: Янв. 13, 2025
The
complex
relationship
between
diet,
the
gut
microbiota,
and
mental
health,
particularly
depression,
has
become
a
focal
point
of
contemporary
research.
This
critical
review
examines
how
specific
dietary
components,
such
as
fiber,
proteins,
fats,
vitamins,
minerals,
bioactive
compounds,
shape
microbiome
influence
microbial
metabolism
in
order
to
regulate
depressive
outcomes.
These
dietary-induced
changes
microbiota
can
modulate
production
metabolites,
which
play
vital
roles
gut–brain
communication.
axis
facilitates
this
communication
through
neural,
immune,
endocrine
pathways.
Alterations
metabolites
central
nervous
system
(CNS)
functions
by
impacting
neuroplasticity,
inflammatory
responses,
neurotransmitter
levels—all
are
linked
onset
course
depression.
highlights
recent
findings
linking
components
with
beneficial
composition
reduced
symptoms.
We
also
explore
challenges
individual
variability
responses
interventions
long-term
sustainability
these
strategies.
underscores
necessity
for
further
longitudinal
mechanistic
studies
elucidate
precise
mechanisms
diet
interactions
be
leveraged
mitigate
paving
way
personalized
nutritional
therapies.
Pharmacological Research,
Год журнала:
2024,
Номер
201, С. 107090 - 107090
Опубликована: Фев. 2, 2024
Depression
is
a
major
global
health
issue
that
urgently
requires
innovative
and
precise
treatment
options.
In
this
context,
saikosaponin
has
emerged
as
promising
candidate,
offering
variety
of
therapeutic
benefits
may
be
effective
in
combating
depression.
This
review
delves
into
the
multifaceted
potential
saikosaponins
alleviating
depressive
symptoms.
We
summarized
effects
on
structural
functional
neuroplasticity,
elaborated
regulatory
mechanism
modulating
key
factors
affect
such
inflammation,
hypothalamic-pituitary-adrenal
(HPA)
axis,
oxidative
stress,
brain-gut
axis.
Moreover,
paper
highlights
existing
gaps
current
researches
outlines
directions
for
future
studies.
A
detailed
plan
provided
clinical
application
saikosaponins,
advocating
more
targeted
to
speed
up
its
transition
from
preclinical
trials
practice.
Redox Biology,
Год журнала:
2024,
Номер
70, С. 103060 - 103060
Опубликована: Фев. 1, 2024
There
is
a
complex
interrelationship
between
the
nervous
system
and
cardiovascular
system.
Comorbidities
of
diseases
(CVD)
with
mental
disorders,
vice
versa,
are
prevalent.
Adults
disorders
such
as
anxiety
depression
have
higher
risk
developing
CVD,
people
CVD
an
increased
being
diagnosed
disorders.
Oxidative
stress
one
many
pathways
associated
pathophysiology
brain
disease.
Nicotinamide
adenine
dinucleotide
phosphate
oxidase
(NOX)
major
generators
reactive
oxygen
species
(ROS)
in
mammalian
cells,
it
enzyme
that
specifically
produces
superoxide.
This
review
summarizes
recent
findings
on
consequences
NOX
activation
thrombosis
depression.
It
also
discusses
therapeutic
effects
pharmacological
strategies
inhibitors
A
better
comprehension
these
processes
could
facilitate
development
new
approaches
for
prevention
treatment
comorbidity
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2645 - 2645
Опубликована: Фев. 24, 2024
The
clinical
features
and
pathophysiology
of
neuropsychiatric
symptoms
(NPSs)
in
dementia
have
been
extensively
studied.
However,
the
genetic
architecture
underlying
neurobiological
mechanisms
NPSs
at
preclinical
stages
cognitive
decline
Alzheimer's
disease
(AD)
remain
largely
unknown.
Mild
behavioral
impairment
(MBI)
represents
an
at-risk
state
for
incident
is
defined
by
emergence
persistent
among
non-demented
individuals
later
life.
These
include
affective
dysregulation,
decreased
motivation,
impulse
dyscontrol,
abnormal
perception
thought
content,
social
inappropriateness.
Accumulating
evidence
has
recently
begun
to
shed
more
light
on
background
MBI,
focusing
its
potential
association
with
factors
related
AD.
Apolipoprotein
E
(APOE)
genotype
MS4A
locus
associated
ZCWPW1
inappropriateness
psychosis,
BIN1
EPHA1
NME8
apathy.
between
MBI
polygenic
risk
scores
(PRSs)
terms
AD
also
explored.
Potential
implicated
neuroinflammation,
synaptic
dysfunction,
epigenetic
modifications,
oxidative
stress
responses,
proteosomal
impairment,
immune
responses.
In
this
review,
we
summarize
critically
discuss
available
emphasis
AD,
aiming
gain
insights
into
mechanisms,
which
till
now
unexplored.
addition,
propose
future
areas
research
emerging
field,
aim
better
understand
molecular
links
decline.
