To
systematically
evaluate
the
incidence
rate
of
depressive
symptoms
in
Chinese
menopausal
women.
Six
major
English
databases
including
PubMed,
EBSCO,
Scopus,
Web
Science,
X-MOL,
Springer,
and
three
WanFang,
CNKI,
VIP
were
retrieved
to
collect
all
observational
studies
on
morbidity
depression
women
published
as
May
10,
2024.
Use
US
Healthcare
Research
Quality
(AHRQ)
tests
assess
quality
individual
studies.
For
aggregation
effect
sizes,
a
random
effects
model
was
adopted.
Funnel
plot,
Begg's
test
Egger's
adopted
determine
publication
bias.
Subgroup
analysis
sensitivity
applied
explore
heterogeneity
summary
estimation.
After
thorough
search,
22
discovered
meet
criteria
included
this
meta-analysis.
The
comprehensive
estimation
using
32%
(95%
confidence
interval:
28–36,
I2
=
100%).
When
visually
inspecting
funnel
interpreting
(p
0.101
>
0.05)
0.176
0.05),
there
no
According
our
records,
among
32%.
results
indicated
that
China,
relatively
high.
It
is
essential
take
notice
screening
population
soon
possible
actively
adopt
prevention
treatment
measures
for
depression.
This
has
important
public
health
significance
identifying
high-risk
groups
patients,
improving
prognosis.
PROSPERO
(
york.ac.uk
),
Identifier
CRD42024542320.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1173 - 1173
Опубликована: Янв. 29, 2025
Progestogens’
anti-anxiety
and
anti-depressive
effects
mechanisms
are
not
well-understood.
Progestogens
hypothesized
to
have
on
behavior,
independent
of
actions
at
nuclear
progestin
receptors
(NPRs)
dependent
allopregnanolone
(5α-pregnan-3α-ol-20-one;
3α,5α-THP),
a
5α-reduced,
neuroactive
metabolite
progesterone
(P4).
Adult
c57
mice
in
behavioral
estrus
(proestrus;
pro)
showed
more
anti-anxiety-like
anti-depressant-like
behavior
higher
levels
estradiol
(E2),
P4,
the
hippocampus/amygdala
complex.
Proestrus
>
5α-reductase
knockout
(5αRKO)
made
central
entries
an
open
field
than
diestrus
5αRKO
that
were
different.
Ovariectomized
(OVX)
administered
1,
2,
or
4
mg/kg
P4
SC
dosage-dependent
increases
(more
behavior);
had
maximal
1–2
P4.
OVX
maximum
with
3α,5α-THP
(4
mg/kg),
c57s
similar
response
but
5αRKOs
was
half
dosage.
receptor
(PRKO)
decreased
immobility
(depression-like
behavior)
forced
swim
task.
Effects
E2
veh
both
groups.
Levels
consistent
field.
brain-derived
neurotrophic
factor
(BDNF)
greater
among
E2-primed
(0.09
mg/kg,
SC)
vs
vehicle-administered
mice.
In
sum,
adult
female
can
be
responsive
for
anti-anxiety/anti-depressant-like
behavior;
such
may
NPRs
require
5α-reduction
E2’s
priming
BDNF
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 5, 2025
Background
Elderly
individuals
with
inadequate
vitamin
B
level
are
at
increased
risk
of
degenerative
conditions,
notably
cardiovascular
disorders,
cognitive
impairments,
and
osteoporosis.
The
relationship
between
niacin
(vitamin
B3)
consumption
osteoporosis
remains
a
subject
debate.
This
study
aimed
to
clarify
the
dietary
intake
incidence
in
postmenopausal
women
aged
≥50
years.
Methods
In
this
study,
we
gathered
details
on
participants’
bone
mineral
density,
status,
intake,
several
other
critical
variables.
Multivariate
logistic
regression
models
were
constructed
determine
association
Restricted
cubic
splines
employed
further
assess
linearity
explore
shape
dose-response
associations.
Additionally,
performed
stratified
interaction
analyses
illustrate
stability
observed
relationships
across
different
subgroups.
Results
After
adjusting
for
all
covariates,
there
was
significant
inverse
(OR
=
0.87;
95%
CI:
0.77–0.97;
p
0.016).
A
negative
(nonlinear:
0.672).
While
revealed
some
differences
risk,
these
not
statistically
significant.
Conclusion
Dietary
exhibited
an
correlation
significantly
reduced
by
13%
every
10
mg/day
increase
daily
among
women.
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 19, 2025
It
is
well
known
that
postmenopausal
women
have
an
increased
risk
of
depression,
and
there
a
dose
correlation
between
carotenoid
intake
depression.
However,
no
clear
study
on
the
relationship
carotenoids
depression
in
women.
To
evaluate
prevalence
The
was
based
National
Health
Nutrition
Examination
Survey
(NHANES)
from
2013
to
2018
included
1089
female
participants.
A
logistic
regression
model
used
verify
restricted
cubic
spline
(RCS)
dose-response
After
adjusting
for
confounding
variables,
Odds
Ratios
(95%
confidence
intervals)
were
found
highest
quartile
compared
with
lower
quartile.
Among
them,
results
lutein
zeaxanthin
β-cryptoxanthin
not
statistically
significant
(P
>
0.05).
Total
lycopene
0.29
(0.10,0.87),
β-carotene
0.41
(0.18,0.94),
total
0.25
(0.09,0.67)
negatively
correlated
When
α-carotene
exceeded
2.90
mg/day,
it
non-linearly
associated
(P-nonlinear
<
0.0022).
1.06
had
L-type
nonlinear
0.0016).
linearly
=
0.3).
2.05
prevalence.
dietary
sufficient
α-carotene,
β-carotene,
lycopene,
lutein,
Still,
β-cryptoxanthin.
Clinical and Experimental Obstetrics & Gynecology,
Год журнала:
2025,
Номер
52(2)
Опубликована: Фев. 24, 2025
Background:
Perimenopausal
women
often
require
hormone
replacement
therapy
(HRT),
which
is
associated
with
an
increased
risk
of
developing
breast
nodules
compared
to
in
other
age
groups.
Consequently,
this
study
aimed
identify
factors
for
nodule
development
perimenopausal
and
develop
a
predictive
model
mitigate
these
risks.
Methods:
This
prospective
cohort
included
436
who
underwent
ultrasound
examinations
at
the
Affiliated
Hospital
Guizhou
Medical
University,
China.
Clinical
data
were
collected,
304
cases
(70%)
assigned
modeling
group,
while
remaining
132
(30%)
allocated
validation
group
using
computerized
randomization
method.
Subsequently,
participants
each
categorized
into
either
control
or
disease
based
on
presence
absence
nodules.
Risk
occurrence
from
analyzed
univariate
analysis
multivariate
logistic
regression.
A
nomogram
was
subsequently
constructed
R
software.
The
accuracy
discriminative
ability
evaluated
both
groups
goodness-of-fit
curves
receiver
operating
characteristic
(ROC)
analysis.
Results:
Factors
exhibiting
significant
differences
regression
model.
results
revealed
that
family
relationships,
modified
Kupperman
score,
depression,
dietary
status,
estradiol
(E2),
triglycerides
(TG),
total
cholesterol
(TC)
independent
during
perimenopause.
In
contrast,
elevated
high
follicle-stimulating
(FSH)
levels
identified
as
protective
factor
against
developed
assess
validity
perimenopause,
curves.
showed
χ2
=
4.936,
p
0.764
training
8.642,
0.071
testing
group.
model’s
discrimination
by
ROC
curve,
showing
area
under
curve
(AUC)
0.941
model,
along
specificity
91.7%,
sensitivity
96.4%.
AUC
also
0.941,
90.2%
98.4%.
Conclusions:
Poor
unhealthy
habits,
severe
menopausal
symptoms,
estrogen
levels,
blood
lipid
FSH
serve
approach
demonstrates
strong
power.
Revista Contemporânea,
Год журнала:
2025,
Номер
5(3), С. e7609 - e7609
Опубликована: Март 5, 2025
A
razão
pela
qual
as
mulheres
na
perimenopausa
são
propensas
a
depressão
não
é
clara,
o
que
pode
estar
relacionado
vários
fatores.
Em
vista
disso,
objetivou-se
sumarizar
evidências
emergentes
sobre
complexa
relação
entre
os
hormônios
esteroides
sexuais
da
perimenopausa,
neurotransmissores
e
(PMD).
Para
tanto,
considerou-se
pertinente
realização
de
uma
revisão
sistemática
literatura
nas
bases
dados
MEDLINE,
Elsevier
LILACS,
no
período
2019-2024.
Foram
selecionados
13
pesquisas
originais
cujos
resultados
mostraram
embora
ciclos
menstruais
continuem
durante
maior
parte
irregulares,
com
picos
declínios
substancialmente
maiores
mais
erráticos
do
dos
principais
anos
reprodutivos;
níveis
plasmáticos
estrogênio
atingem
um
patamar
estável,
porém
baixo,
aumento
persistente
hormônio
folículo-estimulante
(FSH)
luteinizante
(LH).
Demonstrou-se
estradiol
atuar
como
inibidor
monoamina
oxidase
(MAO-A),
sendo
essa
enzima
responsável
por
catabolizar
dopamina
(DA),
norepinefrina
(NE)
5-hidroxitriptamina
(5-HT,
serotonina).
Logo,
ao
haver
deficiência
estradiol,
estará
ativa
e,
consequentemente,
promoverá
degradação
neurotransmissores,
ocasionando,
portanto,
distúrbio
humor.
Por
conta
desta
evidência,
considera-se
imprescindível,
tendo
em
número
nos
próximos
anos,
desenvolvimento
estudos
tema,
modo
só
investigar
transtorno
humor,
mas
desenvolver
abordagens
clínicas
terapêuticas
sucesso.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2940 - 2940
Опубликована: Март 24, 2025
Chronic
stress
significantly
contributes
to
the
development
of
depressive
disorders,
with
hypothalamic-pituitary-adrenal
(HPA)
axis
playing
a
central
role
in
mediating
responses.
This
review
examines
neurobiological
alterations
hippocampus
linked
HPA
dysregulation
chronic
stress-associated
disorders.
The
prolonged
activation
disrupts
cortisol
regulation,
leading
decline
both
physical
and
mental
health.
stress-induced
dysfunction
interacts
inflammatory
pathways
generates
oxidative
stress,
contributing
cellular
damage
neuroinflammation
that
further
aggravates
symptoms.
These
processes
result
structural
functional
hippocampus,
which
is
essential
for
emotional
regulation
cognitive
function.
Comprehending
impact
on
associated
formulating
effective
interventions
summarises
existing
findings
underscores
necessity
future
investigations
into
intervention
strategies
improve
psychological
wellbeing
targeting
at
betterment
human
Brain Behavior & Immunity - Health,
Год журнала:
2024,
Номер
40, С. 100830 - 100830
Опубликована: Июль 21, 2024
In
recent
years,
a
burgeoning
field
of
research
has
focused
on
women's
mental
health
and
psychiatric
conditions
associated
with
perinatal
postpartum
periods.
An
emerging
trend
points
to
the
link
between
hormone
fluctuations
during
pregnancy
that
have
immunologic
consequences
in
cases
depression
psychosis.
The
transition
menopause
(or
"perimenopause")
garnered
comparatively
less
attention,
but
existing
studies
point
influential
interaction
hormonal
immune
pathways.
Moreover,
role
this
cross
talk
perturbing
neural
networks
been
implicated
risk
for
cognitive
decline,
relatively
work
depressed
brain
perimenopause.
This
brief
review
brings
psychoneuroimmunology
lens
perimenopausal
period
by
providing
an
overview
knowledge
suggestions
future
intertwine
these
bodies
work.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(6), С. 6121 - 6138
Опубликована: Июнь 17, 2024
When
postmenopausal
women
are
under
stress
conditions,
this
exacerbates
mood
disorders
and
issues
with
neuroimmune
systems.
The
porcine
placenta
is
known
to
relieve
menopausal
depression
in
clinical
trials,
but
its
underlying
mechanisms
for
anti-inflammatory
functions
remain
poorly
defined.
present
study
was
designed
examine
the
effects
of
enzymatic
hydrolysate
(EPPH)
on
LPS-induced
levels
nitric
oxide
(NO),
prostaglandin
E2
(PGE2),
corticosterone
(CORT),
pro-inflammatory
cytokine
interleukin-1
beta
(IL-1β)
RAW
264.7
macrophage
cells.
In
addition,
neurite
outgrowth
PC12
cells
evaluated
EPPH
growth.
To
mimic
symptoms
menopause-related
depression,
a
stressed
ovariectomized
(OVX)
female
mouse
model
used
evaluate
antidepressant
EPPH.
mice
were
randomly
divided
into
five
groups:
(1)
sham-operated
(Sham)
group,
(2)
OVX
+
repeated
saline-treated
(OVX
ST)
(3)
estradiol
(0.2
mg/kg)-treated
(positive
control)
(4)
(300
(300)
(5)
(1500
(1500)
group.
Female
repeatedly
immobilization-stressed
2
weeks
(2
h/day).
A
tail
suspension
test
conducted
13th
day,
followed
by
forced
swimming
14th
day
assess
After
behavioral
tests,
CORT,
PGE2,
IL-1β
evaluated.
c-Fos
expression
paraventricular
nucleus
(PVN)
using
immunohistochemistry.
concentrations
NO,
stimulated
LPS
significantly
reduced
via
addition
promoted
compared
that
controls.
test,
duration
immobility
treated
1500
ST
group
had
decreased
c-Fos-positive
neurons
PVN
CORT
serum
Sham
These
results
suggested
high
dose
administration
induced
antidepressant-like
effect
downregulating
IL-1β,
PGE2
through
reducing
regions.
