Life Sciences, Год журнала: 2024, Номер 357, С. 123081 - 123081
Опубликована: Сен. 26, 2024
Язык: Английский
Diseases, Год журнала: 2024, Номер 12(5), С. 95 - 95
Опубликована: Май 6, 2024
Long COVID affects both children and adults, including subjects who experienced severe, mild, or even asymptomatic SARS-CoV-2 infection. We have provided a comprehensive overview of the incidence, clinical characteristics, risk factors, outcomes persistent COVID-19 symptoms in encompassing vulnerable populations, such as pregnant women oncological patients. Our objective is to emphasize critical significance adopting an integrated approach for early detection appropriate management long COVID. The incidence severity can significant impact on quality life patients course disease case pre-existing pathologies. Particularly, fragile patients, presence PASC related significantly worse survival, independent from vulnerabilities treatment. It important try achieve recognition management. Various mechanisms are implicated, resulting wide range presentations. Understanding specific factors involved crucial tailoring effective interventions support strategies. Management approaches involve biopsychosocial assessments treatment comorbidities, autonomic dysfunction, well multidisciplinary rehabilitation. overall one gradual improvement, with recovery observed majority, though not all, As research long-COVID continues evolve, ongoing studies likely shed more light intricate relationship between chronic diseases, status, cardiovascular psychiatric disorders, effects This information could guide healthcare providers, researchers, policymakers developing targeted interventions.
Язык: Английский
Процитировано
7
Journal of Affective Disorders, Год журнала: 2024, Номер 356, С. 155 - 161
Опубликована: Апрель 10, 2024
Язык: Английский
Процитировано
6
European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Июль 25, 2024
Abstract Post-COVID syndrome (PCS) describes a persistent complex of symptoms following COVID-19 episode, lasting at least 4 to 12 weeks, depending on the specific criteria used for its definition. It is often associated with moderate severe impairments daily life and represents major burden many people worldwide. However, especially during first two years pandemic, therapeutic diagnostic uncertainties were prominent due novelty disease non-specific definitions that overlooked functional deficits lacked objective assessment. The present work comprehensively examines status PCS as depicted in recent reviews meta-analyses, alongside exploring impairments. We searched database Pubmed meta-analysis evaluating period between May 31, 2022, December 2023. Out 95 studies, 33 selected inclusion our analyses. Furthermore, we extended upon prior research by systematically recording linked identified studies. found fatigue, neurological complaints, exercise intolerance most frequently reported symptoms. In conclusion, over past eighteen months, there has been notable increase quantity quality studies PCS. still remains clear need improvement, particularly regard definition necessary diagnosing this syndrome. Enhancing aspect will render future more comparable precise, thereby advancing understanding
Язык: Английский
Процитировано
6
Clinical Autonomic Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Abstract Purpose The aim of the study is to analyze and compare cognitive profile between 59 patients with long-COVID [LC; 30 them 29 without a positive coronavirus disease 2019 (COVID-19) confirmatory test] 31 postural orthostatic tachycardia syndrome (POTS) matched group 39 healthy control participants. Methods Participants were examined on battery neuropsychological tests, including verbal memory, visuospatial abilities, attention, processing speed, fluency, working visual memory. Anxious–depressive symptomatology was also analyzed then controlled for possible influence performance. Results Patients LC POTS showed significantly lower performance compared peers. Differences anxious depressive symptoms found clinical groups, resulting in test exhibiting highest rates symptoms. After controlling effects anxious–depressive symptomatology, differences eliminated some variables, but additional after post hoc analysis. Conclusions Findings from present contribute toward reinforcement evidence alterations associated POTS. has be considered both groups since it could affecting
Язык: Английский
Процитировано
0
Brain Behavior & Immunity - Health, Год журнала: 2025, Номер unknown, С. 100954 - 100954
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Nervenheilkunde, Год журнала: 2025, Номер 44(01/02), С. 16 - 23
Опубликована: Фев. 1, 2025
Zusammenfassung Nach aktuellen Schätzungen leiden ca. 5–10 % aller symptomatisch Infizierten nach Abklingen der akuten COVID-19-Erkrankung unter länger anhaltenden gesundheitlichen Beeinträchtigungen. Psychische Symptome und kognitive Beeinträchtigungen zählen zu häufigen Symptomen von Long- insbesondere Post-COVID. Während sich für Erwachsene zahlreiche Publikationen Post-COVID finden, ist die Datenlage Kinder Adoleszente verhältnismäßig dünn uneinheitlich. Angesichts weniger dramatischer Akutverläufe in dieser Gruppe Assoziation Schwere des Akutverlaufs zur Wahrscheinlichkeit Auftretens war nicht mit einem bedeutsamen Auftreten gerechnet worden. Insbesondere hinsichtlich ihrer psychischen kognitiven Entwicklungen sind aber besonders durch störende Einflüsse gefährdet. Diese Gefährdungen können Coronavirus-Erkrankung direkt ausgehen. Auch Maßnahmen Eindämmung Pandemie haben wesentlich Entwicklung Kindern Adoleszenten eingegriffen. Für das Verständnis bei Therapieansätzen Kenntnis vorliegenden Forschungsergebnisse relevant. Dieser Artikel fasst daher aktuelle Wissen um Long-COVID psychischer kognitiver zusammen.
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
Many difficult to understand clinical features characterize COVID-19 and Post-Acute Sequelae of (PASC or Long COVID, LC). These can include blood pressure instability, hyperinflammation, coagulopathies, neuropsychiatric complaints. The pathogenesis these remains unclear. SARS-CoV-2 Spike protein Receptor Binding Domain (RBD) binds Angiotensin Converting Enzyme 2 (ACE2) on the surface host cells initiate infection. We hypothesized that some patients may produce anti-RBD antibodies resemble ACE2 sufficiently have ACE2-like catalytic activity, is they are proteolytic abzymes help mediate LC. In previous work, we showed acute had immunoglobulin-associated suggesting indeed produced abzymes. However, it remained unknown whether were seen only in could also be identified convalescent patients. Here show attending a clinic for with persistent pulmonary symptoms presence activity correlates alterations an exercise test.
Язык: Английский
Процитировано
0
Discover Mental Health, Год журнала: 2025, Номер 5(1)
Опубликована: Фев. 24, 2025
While most individuals recover fully from COVID-19, a significant proportion of survivors experience prolonged symptoms lasting three months or more, condition commonly referred to as long-COVID. Long-COVID conditions have been associated with reduced quality life. By utilizing nationally representative sample nearly million Americans, this study provides insights into the prevalence and impact long-COVID on anxiety depression in U.S. We utilize Household Pulse Survey data, which first population-based long-COVID, beginning its June 2022 wave. This survey also includes questions respondents' mental health status—specifically depression. employ quasi-experimental difference-in-differences framework conduct research using control groups, predict among who suffered Approximately 51.8% those surveyed tested positive for COVID-19 these 27.3% reported suffering Individuals were twice likely relative mild/asymptomatic COVID-19. Our analysis at sub-group level revealed that younger adults females disproportionately affected, reporting higher rates both groups. Additionally, lower income educational attainment more challenges. Relative reference group (Asians), Whites, Blacks, Hispanics exhibited significantly odds Notably, was linked incidence males, is consistent previous research. fills gap literature regarding effects The findings provide strong evidence link between depression, large sample, employing rigorous
Язык: Английский
Процитировано
0
Life, Год журнала: 2025, Номер 15(3), С. 439 - 439
Опубликована: Март 11, 2025
The COVID-19 (C-19) pandemic has highlighted the significance of understanding long-term effects this disease on quality life those infected. Long (L-C19) presents as persistent symptoms that continue beyond main illness period, usually lasting weeks to years. One lesser-known but significant aspects L-C19 is its impact neuropsychiatric manifestations, which can have a profound effect an individual’s life. Research shows creates issues such mental fog, emotional problems, and brain symptoms, along with sleep changes, extreme fatigue, severe head pain, tremors seizures, pain in nerves. People cognitive problems plus fatigue mood disorders experience great difficulty handling everyday activities, personal hygiene, social interactions. Neuropsychiatric make people withdraw from activity hurt relationships, thus causing feelings loneliness. unpredictable state generates heavy psychological pressure through suffering, including depression anxiety. changes impairment, swings it hard for work or study effectively, decreases their output at school lowers job contentment. purpose narrative review summarize clinical data present literature regarding manifestations L-C19, identify current methods diagnosis treatment lead correct management condition, highlight these patients’
Язык: Английский
Процитировано
0
Likarska sprava, Год журнала: 2025, Номер 1
Опубликована: Март 31, 2025
Abstract. The aim of the review is to identify and summarize main theories Long COVID, pathogenesis clinical signs. Materials Methods. 110 articles from PubMed, Scopus, Google Scholar, as well WHO data statistics on prevalence COVID for period 2022-2025, which contain relevant information this syndrome, were processed. Special attention paid lesions nervous system psycho-emotional sphere. Conclusions. 1. More than 65 million people are affected by COVID. High susceptibility observed in women, unvaccinated people, patients with chronic diseases. 2. hypotheses development inflammation due a cytokine storm, immune response production antibodies against SARS-CoV-2 proteins, nucleoprotein N spike S, vascular dysfunction increased blood-brain barrier permeability. 3. pathogenetic mechanism post-COVID syndrome persistence virus, dysregulation system, mitochondrial dysfunction, prothrombotic autoantibodies, contributes hypercoagulability. Lesions associated impaired neurotransmission, inflammation, cerebral hypoxia, formation “string vessels,” leads cognitive impairment. 4. leading symptoms damage are: “brain fog,” confusion, prolonged headache, fatigue, autonomic disorders, orthostatic insufficiency, peripheral form neuropathies, myopathies, isolated cranial nerve (anosmia agevia). 5. Depression, anxiety post-traumatic stress disorder, circadian rhythm sleep disorders signs impact sphere psychiatric disorders.
Язык: Английский
Процитировано
0