Experimental Neurology, Год журнала: 2024, Номер 380, С. 114890 - 114890
Опубликована: Июль 20, 2024
Язык: Английский
Neurology International, Год журнала: 2023, Номер 15(3), С. 821 - 841
Опубликована: Июль 6, 2023
SARS-CoV-2, a single-stranded RNA coronavirus, causes an illness known as coronavirus disease 2019 (COVID-19). Long-term complications are increasing issue in patients who have been infected with COVID-19 and may be result of viral-associated systemic central nervous system inflammation or arise from virus-induced hypercoagulable state. incite changes brain function wide range lingering symptoms. Patients often experience fatigue note fog, sensorimotor symptoms, sleep disturbances. Prolonged neurological neuropsychiatric symptoms prevalent can interfere substantially everyday life, leading to massive public health concern. The mechanistic pathways by which SARS-CoV-2 infection sequelae important subject ongoing research. Inflammation- induced blood-brain barrier permeability viral neuro-invasion direct nerve damage involved. Though the mechanisms uncertain, resulting documented numerous patient reports studies. This review examines constellation spectrum seen long COVID incorporates information on prevalence these contributing factors, typical course. Although treatment options generally lacking, potential therapeutic approaches for alleviating improving quality life explored.
Язык: Английский
Процитировано
47
The Lancet Regional Health - Americas, Год журнала: 2024, Номер 30, С. 100688 - 100688
Опубликована: Фев. 1, 2024
Post-acute sequelae after SARS-CoV-2 infection (PASC) remains a concerning long-term complication of COVID-19. Here, we aimed to characterize the epidemiology PASC in Mexico during 2022 and identify potential associations covariates with prevalence using nationally representative data. We analyzed data from Mexican National Health Nutrition Survey (ENSANUT) 24,434 participants, representing 85,521,661 adults ≥20 years. was defined both Institute for Care Excellence (NICE) definition score ≥12. Estimates were stratified by age, sex, rural vs. urban setting, social lag quartiles, number reinfections, vaccination status periods predominance circulating variants. Determinants assessed log-binomial regression models adjusted survey weights. Persistent symptoms reported 12.44% (95% CI 11.89–12.99) years 2022. The most common persistent fatigue, musculoskeletal pain, headache, cough, loss smell or taste, fever, post-exertional malaise, brain fog, anxiety, chest pain. present 21.21% 19.74–22.68) subjects previously diagnosed Over 28.6% patients persistence ≥6 months 14.05% incapacitating symptoms. Higher associated depressive living states high lag. prevalence, particularly its more severe forms, decreased COVID-19 infections Omicron variant predominance. significant public health burden as pandemic transitions into endemic. Promoting reinfection prevention booster may be useful reducing burden. This research supported Instituto Nacional de Geriatría Mexico.
Язык: Английский
Процитировано
22
Biomolecules, Год журнала: 2024, Номер 14(7), С. 835 - 835
Опубликована: Июль 11, 2024
Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.
Язык: Английский
Процитировано
11
Frontiers in Psychiatry, Год журнала: 2025, Номер 15
Опубликована: Янв. 22, 2025
Severe acute respiratory sindrome - Coronavirus 2 (SARS-CoV-2) (Coronavirus disease 19 (COVID-19)) infection can result in long-term health consequences, such as long COVID. The clinical manifestations of COVID include depression, anxiety, brain fog with cognitive dysfunction, memory issues, and fatigue. However, the links between vaccination psychiatric disorders have been less studied. This article describes three patients who reported anxiety after receiving a complete course Pfizer-BioNTech BNT162b2 vaccine. It is important to explore relationship other mental disorders, COVID-19 vaccination, well investigate potential pathogenetic mechanisms.
Язык: Английский
Процитировано
0
Life, Год журнала: 2025, Номер 15(3), С. 439 - 439
Опубликована: Март 11, 2025
The COVID-19 (C-19) pandemic has highlighted the significance of understanding long-term effects this disease on quality life those infected. Long (L-C19) presents as persistent symptoms that continue beyond main illness period, usually lasting weeks to years. One lesser-known but significant aspects L-C19 is its impact neuropsychiatric manifestations, which can have a profound effect an individual’s life. Research shows creates issues such mental fog, emotional problems, and brain symptoms, along with sleep changes, extreme fatigue, severe head pain, tremors seizures, pain in nerves. People cognitive problems plus fatigue mood disorders experience great difficulty handling everyday activities, personal hygiene, social interactions. Neuropsychiatric make people withdraw from activity hurt relationships, thus causing feelings loneliness. unpredictable state generates heavy psychological pressure through suffering, including depression anxiety. changes impairment, swings it hard for work or study effectively, decreases their output at school lowers job contentment. purpose narrative review summarize clinical data present literature regarding manifestations L-C19, identify current methods diagnosis treatment lead correct management condition, highlight these patients’
Язык: Английский
Процитировано
0
Опубликована: Май 2, 2024
Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID's burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.
Язык: Английский
Процитировано
3
Frontiers in Public Health, Год журнала: 2024, Номер 11
Опубликована: Янв. 11, 2024
The COVID-19 pandemic has been emotionally challenging for the entire population and especially people who contracted illness. This systematic review summarizes psychological interventions implemented in long patients presented comorbid emotional disorders.
Язык: Английский
Процитировано
2
Deleted Journal, Год журнала: 2024, Номер 3(1), С. 358 - 358
Опубликована: Янв. 23, 2024
The impact of the COVID-19 pandemic on people’s lives is dramatic. relationship between Brain Fog and Long-COVID, consequences mental health patients, its treatment are objectives this systematic review. An electronic search was carried out databases searched included PubMed, Emerald, EMBASE, Science Direct. Regarding review, data collection English papers with full bibliographies, abstracts, keywords, published in form last 2 years (2020–2022). findings indicate importance a holistic approach Post-COVID Fog. It also necessary for healthcare workers to investigate biological psychosocial background symptoms detail provide appropriate service. However, more scientific studies needed effectiveness approaches benefit public well-being.
Язык: Английский
Процитировано
1
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(12), С. 13565 - 13582
Опубликована: Ноя. 28, 2024
Coronavirus disease 2019 (COVID-19) has been a global pandemic affecting millions of people’s lives, which led to ‘post-COVID-19 fatigue’. Alarmingly, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) not only infects the lungs but also influences heart and brain. Endothelial cell dysfunction hypercoagulation, we know occur with this infection, lead thrombo-inflammation that can manifest as many myriad cardio-cerebrovascular disorders, such brain fog, fatigue, cognitive dysfunction, etc. Additionally, SARS-CoV-2 associated oxidative stress, protein aggregation, cytokine storm, mitochondrial in neurodegenerative diseases. Accordingly, identification molecular targets involved these actions could provide strategies for preventing treating disease. In particular, very common enzyme dipeptidyl peptidase IV (DPPIV) recently identified candidate co-receptor entry virus its involvement infection. addition, DPPIV reported some viruses Middle East (MERS-CoV). It mediates immunologic reactions diseases type diabetes mellitus, obesity, hypertension, have considered prime risk factors stroke among other types Unlike angiotensin-converting (ACE2), implicated aggravating course infection due disruptive effect on inflammatory signaling networks neuro–glia–vascular unit. Regarding neurological, physiological, grounds governing post-COVID-19 review focuses one reasons progressively establishes cerebrovascular grievances following SARS-CoV
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 77 - 96
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0