Subthreshold Depression: A Systematic Review and Network Meta-Analysis of Non-Pharmacological Interventions DOI Creative Commons
Xiaofei Hao,

Yuying Jia,

Jie Chen

и другие.

Neuropsychiatric Disease and Treatment, Год журнала: 2023, Номер Volume 19, С. 2149 - 2169

Опубликована: Окт. 1, 2023

Background: Subthreshold depression (StD) is considered to be the "precursor" stage of major depressive disorder (MDD), which could cause higher risk suicide, disease burden and functional impairment. There have been various non-pharmacological interventions for StD. However, comparison their effectiveness still lacks sufficient evidence. We performed a systematic review network meta-analysis evaluate rank efficacy multiple targeting Methods: conducted thorough search across databases including PubMed, Medline, Embase, Web Science PsycINFO from inception December 2022. All included studies were randomized controlled trials (RCTs) patients with StD compared control group (CG). Several universal scales measuring severity used as outcomes. The surface under cumulative ranking curve (SUCRA) was separately each intervention using "Stata 17.0" software. Results: A total thirty-six included, involving twenty-eight 7417 participants. research found that most superior controls In outcome evaluation by different depression, psychotherapy always ranked first in terms treatment effectiveness, especially Problem-solving Therapy (PST), Behavioral Activation (BAT), Cognitive (CBT)/Internet-based CBT (I-CBT)/Telephone-based (T-CBT). Since groups not directly compared, optimal determined. Conclusion: Here, we show may better choice This study provides some evidence on management selection clinical workers. establish its effect more conclusively, content, format operators require extensive exploration conduct effective, convenient cost-effective implementation primary healthcare. Notably, further also urgently needed find biological neural mechanisms examining whether alters neuroplasticity Keywords: subthreshold intervention, efficacy, comparison, meta-analysis,

Язык: Английский

From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment DOI Creative Commons
Masaru Tanaka, Ágnes Szabó, Tamás Körtési

и другие.

Cells, Год журнала: 2023, Номер 12(22), С. 2649 - 2649

Опубликована: Ноя. 17, 2023

Migraine is a neurovascular disorder that can be debilitating for individuals and society. Current research focuses on finding effective analgesics management strategies migraines by targeting specific receptors neuropeptides. Nonetheless, newly approved calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) have 50% responder rate ranging from 27 to 71.0%, whereas CGRP receptor inhibitors 56 71%. To address the need novel therapeutic targets, researchers are exploring potential of another secretin family peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), as ground-breaking treatment avenue migraine. Preclinical models revealed how PACAP affects trigeminal system, which implicated in headache disorders. Clinical studies demonstrated significance migraine pathophysiology; however, few clinical trials remain inconclusive: 1 mAb, AMG 301 showed no benefit prevention, while ligand Lu AG09222 significantly reduced number monthly days over placebo phase 2 trial. Meanwhile, vasoactive intestinal (VIP) gaining interest new target. In light recent advances research, we emphasize promising target treatment, highlighting member antimigraine armamentarium, especially patients who do not respond or contraindicated anti-CGRP therapies. By updating our knowledge its unique contribution pathophysiology, pave way reinforcing other peptides, including VIP, option migraines.

Язык: Английский

Процитировано

40
Editorial: Case reports in neuroimaging and stimulation DOI Creative Commons
Simone Battaglia, André Schmidt, Stefanie Hassel

и другие.

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Авг. 2, 2023

EDITORIAL article Front. Psychiatry, 02 August 2023Sec. Neuroimaging Volume 14 - 2023 | https://doi.org/10.3389/fpsyt.2023.1264669

Язык: Английский

Процитировано

38
The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies DOI Creative Commons
Francesco Tortora, Abed L. Hadipour, Simone Battaglia

и другие.

Brain Sciences, Год журнала: 2023, Номер 13(8), С. 1197 - 1197

Опубликована: Авг. 12, 2023

Fear is characterized by distinct behavioral and physiological responses that are essential for the survival of human species. conditioning (FC) serves as a valuable model studying acquisition, extinction, expression fear. The serotonin (5-hydroxytryptamine, 5-HT) system known to play significant role in emotional motivational aspects behavior, including fear learning expression. Accumulating evidence from both animal studies suggests brain regions involved FC, such amygdala, hippocampus, prefrontal cortex, possess high density 5-HT receptors, implicating crucial involvement aversive learning. Additionally, exploring gene polymorphisms have indicated their potential influence on FC. Therefore, objective this work was review existing linking with memory humans. Through comprehensive screening PubMed Web Science databases, 29 relevant were included final review. These investigated relationship between using drug manipulations or 5-HT-related polymorphisms. results suggest elevated levels enhance learning, indicating modulation 5-HT2A receptors regulates Understanding neurochemical messenger associative can provide insights into psychiatric disorders anxiety post-traumatic stress disorder (PTSD), among others.

Язык: Английский

Процитировано

35
Editorial: Towards a mechanistic understanding of depression, anxiety, and their comorbidity: perspectives from cognitive neuroscience DOI Creative Commons
Masaru Tanaka, Chong Chen

Frontiers in Behavioral Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Авг. 15, 2023

EDITORIAL article Front. Behav. Neurosci., 15 August 2023Sec. Emotion Regulation and Processing Volume 17 - 2023 | https://doi.org/10.3389/fnbeh.2023.1268156

Язык: Английский

Процитировано

34
Emerging Translational Research in Neurological and Psychiatric Diseases: From In Vitro to In Vivo Models DOI Open Access
Masaru Tanaka, Ágnes Szabó, László Vécsei

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15739 - 15739

Опубликована: Окт. 30, 2023

Revealing the underlying pathomechanisms of neurological and psychiatric disorders, searching for new biomarkers, developing novel therapeutics all require translational research [...].

Язык: Английский

Процитировано

34
Exercise for Mental Well-Being: Exploring Neurobiological Advances and Intervention Effects in Depression DOI Creative Commons
Jianchang Ren, Haili Xiao

Life, Год журнала: 2023, Номер 13(7), С. 1505 - 1505

Опубликована: Июль 4, 2023

Depression is a common mental disorder in which patients often experience feelings of sadness, fatigue, loss interest, and pleasure. Exercise widely used intervention for managing depression, but the specific molecular mechanisms underlying its antidepressant effect are unclear. In this narrative review, we aim to synthesize current knowledge on molecular, neural, physiological through exercise exerts discuss various interventions depression. We conducted review literature topic Our suggests that impacts peripheral tryptophan metabolism, central inflammation, brain-derived neurotrophic factors peroxisome proliferator-activated receptor γ activating factor 1α (PGC-1α) skeletal muscles. The uncarboxylated osteocalcin facilitates "bone-brain crosstalk", corrects atypical expression brain-gut peptides, modulates cytokine production neurotransmitter release, regulates inflammatory pathways microRNA expression. Aerobic recommended at frequencies 3 5 times per week with medium high intensity. Here highlight significant potential therapy supported by effect. Understanding neural involved exercise's opens new avenues developing novel therapies

Язык: Английский

Процитировано

28
Emerging Translational Research in Neurological and Psychiatric Diseases: From In Vitro to In Vivo Models DOI Open Access
Masaru Tanaka, Ágnes Szabó, László Vécsei

и другие.

Опубликована: Окт. 12, 2023

Revealing the underlying pathomechanisms of neurological and psychiatric disorders, searching for new biomarkers, developing novel therapeutics all require translational research. In vivo in vitro disease models have been instrumental casting light on complex polygenic, multifactorial, heterogeneous mechanisms. most recent years, advanced preclinical revealed intriguing interaction sex/gender aging with pathogenesis clinical manifestations diseases. However, despite these advancements, there is still a great deal work to be done fully comprehend mechanisms diseases develop treatments that can significantly improve lives those who suffer from them. The current challenge field disease-modifying, effective long-lasting debilitating conditions high burden disease.The first edition research topic ‘Emerging Translational Research Neurological Psychiatric Diseases: From Vitro Vivo Models’ reinforces playing critical role bridging gap between basic applications. Also, it provides platform researchers share their findings advancements this field. This collection gathers 25 papers offering insights into latest potential avenues treatments. These cover various topics, including development models, use methods, application qualitative quantitative methods.

Язык: Английский

Процитировано

25
The Involvement of Antioxidants in Cognitive Decline and Neurodegeneration: Mens Sana in Corpore Sano DOI Creative Commons
Claudio Nazzi, Alessio Avenanti, Simone Battaglia

и другие.

Antioxidants, Год журнала: 2024, Номер 13(6), С. 701 - 701

Опубликована: Июнь 7, 2024

With neurodegenerative disorders being on the rise, a great deal of research from multiple fields is conducted in order to further knowledge and propose novel therapeutic interventions. Among these investigations, role antioxidants contrasting cognitive decline putting forward interesting promising results. In this review, we aim collect evidence that focused variety antioxidant-rich foods improving or stabilizing functions, memory, Alzheimer’s disease, most common disorder. Specifically, considered collected humans, either through longitudinal studies randomized, placebo-controlled ones, which evaluated performance, memory abilities, progression level neurodegeneration. Overall, despite between study protocols, cohorts participants involved, neuropsychological tests used, investigated antioxidants, there solid trend suggests properties may be helpful hampering older people. Thus, help future will elucidate neuroprotection lead development interventions take into account such findings provide more global approach treating disorders.

Язык: Английский

Процитировано

12
Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction DOI Creative Commons
Masaru Tanaka, László Vécsei

Journal of Neural Transmission, Год журнала: 2024, Номер 131(12), С. 1367 - 1387

Опубликована: Авг. 7, 2024

Millions of individuals around the world are afflicted with Parkinson's disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, distinguished professor neurologist, has made substantial advancements in domain PD research, encompassing both fundamental scientific investigations practical applications. His research illuminated etiology treatment PD, as well function energy metabolism premotor symptoms. As precursor to number neurotransmitters neuromodulators that implicated pathophysiology he also investigated application tryptophan (Trp) derivatives disease. principal findings insights summarized synthesized this narrative review article, which emphasizes challenges implications for future research. This aims identify analyze key contributions Reichmann field ultimate goal informing directions domain. By examining Reichmann's work, study seeks provide comprehensive understanding his major how they can be applied advance diagnosis PD. paper explores potential intersection emerging avenues, such investigation Trp its metabolites, particularly kynurenines, could lead new therapeutic strategies managing disorders like

Язык: Английский

Процитировано

9
Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence DOI Open Access

Yandra Cervelim Nunes,

Nathalia. M. Mendes,

Enzo Pereira de Lima

и другие.

Nutrients, Год журнала: 2024, Номер 16(16), С. 2721 - 2721

Опубликована: Авг. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Язык: Английский

Процитировано

8