Effectiveness and safety of acupuncture for melasma: A meta-analysis of randomized controlled trials
Jiayu Su,
Tingwei Quan,
T. Vivian Liao
и другие.
EXPLORE,
Год журнала:
2025,
Номер
21(1), С. 103108 - 103108
Опубликована: Янв. 1, 2025
Treating
melasma
remains
challenging.
We
conducted
a
meta-analysis
to
assess
the
effectiveness
and
safety
of
acupuncture
as
treatment
option.
searched
three
English
four
Chinese
databases
up
January
2,
2024.
The
primary
outcome
was
total
effective
rate,
while
secondary
outcomes
included
skin
lesion
area
color
scores,
score,
adverse
effects.
Study
quality
assessed
using
risk
bias
tool,
data
were
analyzed
with
Review
Manager
5.4.
GRADE
approach
evaluated
evidence
certainty.
This
study
22
studies
1644
participants.
Findings
indicate
that
significantly
outperforms
Western
medicine
other
treatments
(risk
ratio
[RR]
=
1.21,
95
%
confidence
interval
[CI]
(1.18,
1.30),
P
<
0.00001,
I²
34
%).
Acupuncture
effectively
reduces
lesions
(mean
difference
[MD]
-0.35,
CI
(-0.52,
-0.19),
0.0001,
93
%),
lightens
(MD
-0.45,
(-0.58,
-0.31),
89
lowers
score
-1.00,
(-1.29,
-0.70),
79
Adverse
reactions
infrequent
acupuncture.
most
common
needling
sites
in
facial
area,
noted
17
studies.
Sanyinjiao
(SP6)
frequently
used
acupoint
(n
8),
followed
by
Hegu
(LI4)
7)
Xuehai
(SP10)
7).
Other
commonly
acupoints
Tianshu
(ST25),
Zusanli
(ST36),
Taichong
(LR3),
Zhongwan
(RN12).
All
outcomes,
except
for
outcome,
rated
very
low
quality.
review
confirms
therapy
scores.
appears
be
safe
option
melasma;
however,
results
should
interpreted
cautiously
due
potential
publication
regional
biases.
CRD42024503394.
Язык: Английский
Melasma secondary to drugs: a real-world pharmacovigilance study of the FDA adverse event reporting system (FAERS)
BMC Pharmacology and Toxicology,
Год журнала:
2025,
Номер
26(1)
Опубликована: Март 31, 2025
Abstract
Background
Melasma
is
a
common
hyperpigmentation
disorder
that
causes
significant
distress
to
patients.
In
the
real
world,
it
closely
associated
with
various
medications,
making
timely
identification
and
discontinuation
of
causative
drugs
an
important
aspect
clinical
management.
This
study
investigates
relationship
between
melasma
drug
exposure
based
on
data
from
FDA
Adverse
Event
Reporting
System
(FAERS)
database.
Methods
includes
reports
first
quarter
2004
second
2024,
focusing
cases
related
melasma.
We
employed
four
statistical
methods
analyze
association
suspected
adverse
events
Results
Within
specific
timeframe,
we
extracted
total
408
reaction
The
result
shows
higher
number
in
female
patients
compared
male
United
States
had
highest
reported
cases.
identified
22
were
notably
Among
these,
contraceptive
“Ethinylestradiol
norethindrone”
demonstrated
strongest
signal
association.
Conclusions
notable
proportion
coincided
use.
mechanisms
involved
include
hormonal
disturbances
oxidative
stress.
Язык: Английский
Trpv2 Promotes Melanogenesis by Activating the Ca2+/Camp/Pka/Creb Signaling Pathway
Опубликована: Янв. 1, 2025
Язык: Английский
Melasma: current aspects of topical correction
Russian Journal of Clinical Dermatology and Venereology,
Год журнала:
2024,
Номер
23(4), С. 438 - 438
Опубликована: Янв. 1, 2024
Язык: Английский
Latin American consensus on the treatment of melasma
International Journal of Dermatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 16, 2024
Abstract
Melasma
is
a
chronic,
relapsing
hyperpigmentation
disorder
that
primarily
affects
photoexposed
areas,
occurring
most
frequently
in
adult
women
with
darker
skin
phototypes.
The
primary
factors
contributing
to
its
development
include
sun
exposure,
sex
hormones
(e.g.,
pregnancy),
and
genetic
predisposition.
highly
prevalent
Latin
America,
where
many
countries
lie
intertropical
zones
exhibit
significant
ethnic
diversity
because
of
centuries
intermixing
among
Native
Americans,
Europeans,
Sub‐Saharan
Africans.
Nine
American
experts
formulated
DELPHI‐based
consensus
develop
valuable
approach
for
treating
melasma
this
diverse
population.
After
establishing
an
accurate
diagnosis,
assessing
the
impact
on
quality
life,
determining
disease
severity,
recommends
mitigating
known
triggers
promoting
rigorous
photoprotection.
Active
therapy
should
be
tailored
based
individual
characteristics
pregnancy
status,
previous
treatments,
sensitivity).
Treatment
options
topical
depigmenting
agents,
systemic
therapies,
procedural
interventions
such
as
laser
therapy,
microneedling,
chemical
peels.
Periodic
reassessment
treatment
essential,
strategies
adjusted
if
targeted
outcomes
are
not
achieved.
Once
clinical
remission
attained,
patients
continue
using
agents
maintain
strict
photoprotection
measures
prevent
recurrence.
Язык: Английский
Self-Delivering RNAi Compounds for Reduction of Hyperpigmentation
Clinical Cosmetic and Investigational Dermatology,
Год журнала:
2024,
Номер
Volume 17, С. 3033 - 3044
Опубликована: Дек. 1, 2024
Abnormal
melanin
synthesis
causes
hyperpigmentation
disorders
like
melasma
and
lentigines,
impacting
psychological
well-being.
RNA
interference
(RNAi)
uses
small
molecules
to
inhibit
gene
expression
by
targeting
specific
mRNA,
silencing
genes
involved
in
undesirable
cellular
functions.
This
study
assessed
INTASYL
compounds,
self-delivering
RNAi
molecules,
designed
target
reduce
tyrosinase
decrease
pigmentation.
Язык: Английский