Effectiveness and safety of acupuncture for melasma: A meta-analysis of randomized controlled trials

EXPLORE, Journal Year: 2025, Volume and Issue: 21(1), P. 103108 - 103108

Published: Jan. 1, 2025

Treating melasma remains challenging. We conducted a meta-analysis to assess the effectiveness and safety of acupuncture as treatment option. searched three English four Chinese databases up January 2, 2024. The primary outcome was total effective rate, while secondary outcomes included skin lesion area color scores, score, adverse effects. Study quality assessed using risk bias tool, data were analyzed with Review Manager 5.4. GRADE approach evaluated evidence certainty. This study 22 studies 1644 participants. Findings indicate that significantly outperforms Western medicine other treatments (risk ratio [RR] = 1.21, 95 % confidence interval [CI] (1.18, 1.30), P < 0.00001, I² 34 %). Acupuncture effectively reduces lesions (mean difference [MD] -0.35, CI (-0.52, -0.19), 0.0001, 93 %), lightens (MD -0.45, (-0.58, -0.31), 89 lowers score -1.00, (-1.29, -0.70), 79 Adverse reactions infrequent acupuncture. most common needling sites in facial area, noted 17 studies. Sanyinjiao (SP6) frequently used acupoint (n 8), followed by Hegu (LI4) 7) Xuehai (SP10) 7). Other commonly acupoints Tianshu (ST25), Zusanli (ST36), Taichong (LR3), Zhongwan (RN12). All outcomes, except for outcome, rated very low quality. review confirms therapy scores. appears be safe option melasma; however, results should interpreted cautiously due potential publication regional biases. CRD42024503394.

Language: Английский

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Melasma secondary to drugs: a real-world pharmacovigilance study of the FDA adverse event reporting system (FAERS)

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 31, 2025

Abstract Background Melasma is a common hyperpigmentation disorder that causes significant distress to patients. In the real world, it closely associated with various medications, making timely identification and discontinuation of causative drugs an important aspect clinical management. This study investigates relationship between melasma drug exposure based on data from FDA Adverse Event Reporting System (FAERS) database. Methods includes reports first quarter 2004 second 2024, focusing cases related melasma. We employed four statistical methods analyze association suspected adverse events Results Within specific timeframe, we extracted total 408 reaction The result shows higher number in female patients compared male United States had highest reported cases. identified 22 were notably Among these, contraceptive “Ethinylestradiol norethindrone” demonstrated strongest signal association. Conclusions notable proportion coincided use. mechanisms involved include hormonal disturbances oxidative stress.

Language: Английский

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Trpv2 Promotes Melanogenesis by Activating the Ca2+/Camp/Pka/Creb Signaling Pathway

Published: Jan. 1, 2025

Language: Английский

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Melasma: current aspects of topical correction

Russian Journal of Clinical Dermatology and Venereology, Journal Year: 2024, Volume and Issue: 23(4), P. 438 - 438

Published: Jan. 1, 2024

Language: Английский

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Latin American consensus on the treatment of melasma

International Journal of Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Melasma is a chronic, relapsing hyperpigmentation disorder that primarily affects photoexposed areas, occurring most frequently in adult women with darker skin phototypes. The primary factors contributing to its development include sun exposure, sex hormones (e.g., pregnancy), and genetic predisposition. highly prevalent Latin America, where many countries lie intertropical zones exhibit significant ethnic diversity because of centuries intermixing among Native Americans, Europeans, Sub‐Saharan Africans. Nine American experts formulated DELPHI‐based consensus develop valuable approach for treating melasma this diverse population. After establishing an accurate diagnosis, assessing the impact on quality life, determining disease severity, recommends mitigating known triggers promoting rigorous photoprotection. Active therapy should be tailored based individual characteristics pregnancy status, previous treatments, sensitivity). Treatment options topical depigmenting agents, systemic therapies, procedural interventions such as laser therapy, microneedling, chemical peels. Periodic reassessment treatment essential, strategies adjusted if targeted outcomes are not achieved. Once clinical remission attained, patients continue using agents maintain strict photoprotection measures prevent recurrence.

Language: Английский

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Self-Delivering RNAi Compounds for Reduction of Hyperpigmentation

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 3033 - 3044

Published: Dec. 1, 2024

Abnormal melanin synthesis causes hyperpigmentation disorders like melasma and lentigines, impacting psychological well-being. RNA interference (RNAi) uses small molecules to inhibit gene expression by targeting specific mRNA, silencing genes involved in undesirable cellular functions. This study assessed INTASYL compounds, self-delivering RNAi molecules, designed target reduce tyrosinase decrease pigmentation.

Language: Английский

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