International Dairy Journal, Год журнала: 2024, Номер unknown, С. 106112 - 106112
Опубликована: Окт. 1, 2024
Язык: Английский
Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110321 - 110321
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Pharmacology Biochemistry and Behavior, Год журнала: 2024, Номер 245, С. 173887 - 173887
Опубликована: Окт. 6, 2024
Язык: Английский
Процитировано
3
Human Brain Mapping, Год журнала: 2025, Номер 46(1)
Опубликована: Янв. 1, 2025
ABSTRACT The brain develops most rapidly during pregnancy and early neonatal months. While prior electrophysiological studies have shown that aperiodic activity undergoes changes across infancy to adulthood, the role of gestational duration in periodic remains unknown. In this study, we aimed bridge gap by examining associations between EEG power spectrum both neonates toddlers. This cross‐sectional study involved data from 73 (postnatal age 1–5 days, 40 females) 56 toddlers 2.9–3.2 years, 28 FinnBrain Birth Cohort Study. spectra were parameterized components using SpecParam tool. We tested as well postnatal parameters while including birth weight child sex covariates. For neonates, multilevel models employed, considering different acquisitions (sleep auditory paradigm + sleep), toddlers, regression used only was available. found longer associated with a steeper frequencies Effect especially strong ( β = 0.45, p 0.004), it remained nearly statistically significant 0.061). quadratic association beta center frequency (12.5–30 Hz) found. overall higher females compared males. Offset (calculated curve at 2.5 theta had negative but not Our results suggest may relatively long‐lasting effects on physiology. possible behavioral cognitive consequences these are enticing topics for future research.
Язык: Английский
Процитировано
0
Journal of Affective Disorders, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2024, Номер 340, С. 119268 - 119268
Опубликована: Дек. 19, 2024
Язык: Английский
Процитировано
2
Applied Neuropsychology Child, Год журнала: 2024, Номер unknown, С. 1 - 10
Опубликована: Июль 29, 2024
Objective To explore the relationship between physical fitness index and executive function in Chinese adolescents, to provide a reference for improving development of adolescents.
Язык: Английский
Процитировано
1
Journal of Neural Transmission, Год журнала: 2024, Номер unknown
Опубликована: Сен. 26, 2024
Язык: Английский
Процитировано
1
Annals of Clinical and Translational Neurology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 31, 2024
Abstract Background Variants in the GABRA2 gene, which encodes α2 subunit of γ‐aminobutyric acid A receptor, have been linked to a rare form developmental and epileptic encephalopathy (DEE) referred as DEE78. Only eight patients reported globally. This study presents clinical presentation genetic analysis Chinese family with child diagnosed DEE78, due novel variant. Methods Genetic diagnosis was performed using trio‐whole exome sequencing, followed by bioinformatics predictions pathogenicity. Structural modeling assessed potential impact mutant plasmid constructed transfected into 293 T cells. Western blotting (WB) used evaluate protein expression, while co‐immunoprecipitation (Co‐IP) analyzed interactions GABRB3 GABRG2 proteins. Immunofluorescence (IF) subcellular localization protein. Results The 6‐year‐old male proband presented seizures starting at age two, along global delay hypotonia. testing revealed heterozygous de novo variant gene (NM_000807: c.923C>T, p.Ala308Val). suggested that this is located within extracellular domain, may disrupt hydrogen bonding GABRG2. WB Co‐IP showed reduced expression impaired interactions, potentially destabilizing pentamer receptor complex. If did not affect localization. Conclusion identified likely pathogenic domain causing DEE phenotype. results expand genotypic phenotypic spectrum ‐related DEE.
Язык: Английский
Процитировано
1
Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17
Опубликована: Дек. 10, 2024
KCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of transmembrane gradient, thereby enabling synaptic inhibition within CNS. Herein, we highlight hypofunction as a fundamental conserved pathology contributing to neuronal circuit excitation/inhibition (E/I) imbalances that underly epilepsies, chronic pain, neuro-developmental/-traumatic/-degenerative/-psychiatric disorders. Indeed, downstream both acquired genetic factors, multiple pathologies (e.g., hyperexcitability inflammation) converge impair KCC2-dependent in When occurs, affected neurons are disinhibited due impaired inhibitory responses GABA/glycine. This causes hyperexcitability, disinhibition neuron circuits, disrupted neurological functions. More recently, was identified genetically-validated target epilepsy, intellectual disability, autism spectrum disorder, pathogenic mutations human SLC12A5 gene were linked psychiatric/mood The broad therapeutic utility KCC2-upmodulating drugs relates its critical role determining activity GABAergic neurotransmission, mechanism widely targeted by several drugs. However, cases neurotransmission can be depolarizing/excitatory, impairing endogenous while also limiting effectiveness existing therapeutics targeting/requiring pathway inhibition. Several preclinical reports have shown upmodulating treatments rescue increase efficacy anti-seizure analgesic medications. Thus, first-in-class KCC2-potentiating therapy would provide novel restoring physiological addressing drug resistance patients with E/I imbalance pathologies. discuss progress toward further work needed develop treat disorder patients.
Язык: Английский
Процитировано
0
International Dairy Journal, Год журнала: 2024, Номер unknown, С. 106112 - 106112
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0