Investigating the anticancer properties of urolithin B in triple negative breast cancer: In vivo and in vitro insights

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117224 - 117224

Опубликована: Янв. 1, 2025

Язык: Английский

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Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle design

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 17, 2025

Breast cancer causes the deaths of approximately 685,000 women annually, posing a severe threat to women's health. Consequently, there is an urgent need for low-cost, low-toxicity and effective therapeutic methods prevent or mitigate breast progression. PDBP are natural, non-toxic, affordable substances have demonstrated excellent anti-breast activities in inhibiting proliferation, migration, invasion, promoting apoptosis both vitro vivo, thus effectively preventing cancer. However, no comprehensive reviews summarizing effects mechanisms on treatment Therefore, this review described inhibitory active peptides from different plant protein sources Additionally, we summarized advantages preparation protein-derived anticancer peptide-encapsulated nanoparticles their This provides scientific basis understanding offers guidance development adjuvants enriched with these peptides.

Язык: Английский

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Assessing the Impact of Organ Failure and Metastases on Quality of Life in Breast Cancer Patients: A Prospective Study Based on Utilizing EORTC QLQ-C30 and EORTC QLQ-BR45 Questionnaires in Romania

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(2), С. 214 - 214

Опубликована: Фев. 16, 2024

Breast cancer (BC) significantly impacts the quality of life (QoL) affected individuals. This study, conducted at Colțea Clinical Hospital, Bucharest, aimed to assess impact organ failures and metastases on QoL in breast patients using EORTC QLQ-C30 QLQ-BR45 questionnaires survival rate understand clinical journey status patients. From January 2019 October 2022, a prospective, observational study surveyed 874 patients, revealing 201 fatalities, 66 refusals, 607 eligible participants. Results indicated statistically significant differences various aspects for experiencing heart failure, including physical functioning, pain, insomnia, global health status, overall summary score. Kidney failure exhibited significance functioning body image, sexual endocrine symptoms QLQ-BR45. Respiratory demonstrated across multiple domains. Patients with bone reported lower (p = 0.006) increased pain 0.002). has revealed an 5-year expectancy 68.8%, rates 93.8% Stage I, 86.3% II, 77.2% III cancer. Metastatic have shown 35.6% over 45 months, median duration 36 months. A limitation our was administration questionnaire only once, preventing us from quantifying specific treatment types life. emphasizes necessity standardized assessments practice initial presentation ongoing follow-up.

Язык: Английский

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Analyzing Cancer Incidence Trends in Oman From 1996 to 2019: A Comprehensive Study of the National Cancer Annual Reports

JCO Global Oncology, Год журнала: 2024, Номер 10

Опубликована: Янв. 25, 2024

PURPOSE Previous studies have reported that cancer incidence trends in Oman varied by tumor site and sex. No comprehensive analysis of all sites had been reported. The objective this study is to analyze calculate the annual percent change (APC) age-standardized rates (ASRs) for all-cancer 61 individual Omani men women from 1996 2019. METHODS We gathered data National Cancer Registry cancers combined sites. estimated APC using Poisson regression. RESULTS ASR population increased 23% (from 95/100,000 117.2/100,000 2019), with increase being more pronounced females (48% v 7% males). Among male population, there was significant ASRs colon, rectum, thyroid, prostate cancers, APCs 6.92%, 4.24%, 4.19%, 2.03%, respectively. females, showed (APC = 1.39%), increasing were observed uterine, breast (APCs 7.57%, 7.08%, 5.19%, 5.16%, respectively). CONCLUSION significantly but not men. Uterine highest APC. Colorectal thyroid both males females. Breast trends. Further research needed explore factors contributing incidences.

Язык: Английский

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A contemporary review of breast cancer risk factors and the role of artificial intelligence

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Апрель 18, 2024

Breast cancer continues to be a significant global health issue, necessitating advancements in prevention and early detection strategies. This review aims assess synthesize research conducted from 2020 the present, focusing on breast risk factors, including genetic, lifestyle, environmental aspects, as well innovative role of artificial intelligence (AI) prediction diagnostics.

Язык: Английский

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Global burden and attributable risk factors of breast cancer in young women: historical trends from 1990 to 2019 and forecasts to 2030 by sociodemographic index regions and countries

Journal of Global Health, Год журнала: 2024, Номер 14

Опубликована: Июль 19, 2024

Abstract Background Breast cancer in young women (BCY) is much less common but has significant health sequelae and societal costs. We aimed to evaluate the global regional burden of breast aged 15–39 years from 1990 2019. Methods collected detailed data on Global Burden Disease Study 2019 (GBD 2019) Data Resources. The age-standardised incidence rate (ASIR), mortality (ASMR), disability-adjusted life (ASDR), estimated annual percentage change (EAPC) were used assess disease BCY. Bayesian Age-Period-Cohort model was forecast 2020 2030. Results From 2019, increases ASIR found for BCY (EAPC = 0.59, 95% confidence interval (CI) 0.5 0.68), whereas decreases ASMR −0.41, CI −0.53 −0.3) ASDR −0.35, −0.46 −0.24). Across countries with varying sociodemographic indexes (SDI), all regions showed an upward trend morbidity, except a high SDI. While DALYs rates have decreased high, high-middle, middle SDI, they increased low-middle low Countries lower SDIs are projected bear greatest over next decade, including both categories. Alcohol use main risk factor attributed deaths most countries, while exposure second hand smoke predominant SDI countries. Conclusions rise worldwide, there differences. or face even more challenges, as experienced increasing than higher SDIs.

Язык: Английский

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Pharmacovigilance study of adverse reactions of anti-HER-2 drugs for the treatment of HER-2-positive breast cancer based on the FAERS database

Breast Cancer Research, Год журнала: 2025, Номер 27(1)

Опубликована: Апрель 9, 2025

There are three categories of drugs that treat human epidermal growth factor receptor type 2 (HER-2) positive breast cancer: monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), and tyrosine kinase inhibitors (TKIs). The purpose this study is to analyze compare the adverse reactions classes anti-HER-2 various body systems in patients based on FDA Adverse Event Reporting System (FAERS). All data reports were extracted from FAERS between 2004 2024. Data mining events associated with was carried out using disproportionality analysis. A multivariate logistic regression analysis conducted explore risk factors AEs leading hospitalization. total 47,799 screened for drugs, among which ADC caused largest proportion deaths. MAb has strongest ADR signals "cardiac disorders". Moreover, trastuzumab a greater cardiotoxicity. Logistic revealed treatment mAbs should be wary serious "infections infestations" "metabolism nutrition "endocrine disorders" highest prolonged hospitalization due deruxtecan (T-DXd). safety tucatinib TKI than other drugs. In general, perspective effects patients, we focus mAb-associated disorders", ADC-associated "hepatobiliary "respiratory, thoracic mediastinal TKI-associated "gastrointestinal disorders.

Язык: Английский

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Epidemiology and clinicopathologic features of breast cancer in China and the United States

Translational Cancer Research, Год журнала: 2023, Номер 12(7), С. 1826 - 1835

Опубликована: Июль 1, 2023

Breast cancer has kept increasing since the past decades and incidence rate is highest among all neoplasms nowadays. China, as well other countries, faces severe burden from population with breast cancer. This study aimed to analyze epidemiology clinicopathologic features of in China United States (US).Data hospitalized patients diagnosed primary between 1 January 1999 31 December 2014 Cancer Hospital, Chinese Academy Medical Sciences (CHCAMS) were reviewed. Clinical demographic data extracted medical history systems, sixteen-year trends analyzed. Meanwhile, retrieved Surveillance, Epidemiology, End Results (SEER) database used for comparisons.A total 18,768 included CHCAMS, 18,685 female cases (99.57%) 81 male (0.43%). A 762,954 SEER database, US, 757,357 (99.27%) 5,597 (0.73%). The peak age was 45-49 years old while 55-59 2006 60-64 2007 US. There more young (<35 years, 6.56% vs. 1.97%, P<0.001), less elderly (≥65 9.99% 40.88%, stage I (24.93% 48.84%, P<0.001) III (21.00% 12.35%, than Patients aged 30-49 had a decreased trend (P<0.001), 55-64 an increased (P<0.001) same also observed Mucinous carcinoma histological grade both US (P<0.001).The unique (earlier age, younger patients, advanced stage, etc.), typical should be seriously recognized, so guide future prevention management strategies.

Язык: Английский

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Disparities in Breast Cancer Diagnostics: How Radiologists Can Level the Inequalities

Cancers, Год журнала: 2023, Номер 16(1), С. 130 - 130

Опубликована: Дек. 27, 2023

Access to medical imaging is pivotal in healthcare, playing a crucial role the prevention, diagnosis, and management of diseases. However, disparities persist this scenario, disproportionately affecting marginalized communities, racial ethnic minorities, individuals facing linguistic or cultural barriers. This paper critically assesses methods mitigate these disparities, with focus on breast cancer screening. We underscore scientific mobility as vital tool for radiologists advocate healthcare policy changes: it not only enhances diversity competence within radiology community but also fosters international cooperation knowledge exchange among institutions. Efforts ensure competency are discussed, including ongoing education, sensitivity training, workforce diversification. These initiatives key improving patient communication reducing disparities. highlights changes legislation promoting equal access essential screening services like mammography. explore challenges potential teleradiology remote underserved areas. In era artificial intelligence, emphasizes necessity validating its models across spectrum populations prevent bias achieve equitable outcomes. Finally, importance collaboration illustrated, showcasing sharing insights strategies overcome global barriers imaging. Overall, offers comprehensive overview related proposes actionable address challenges, aiming delivery.

Язык: Английский

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Semi-supervised recognition for artificial intelligence assisted pathology image diagnosis

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 20, 2024

The analysis and interpretation of cytopathological images are crucial in modern medical diagnostics. However, manually locating identifying relevant cells from the vast amount image data can be a daunting task. This challenge is particularly pronounced developing countries where there may shortage expertise to handle such tasks. acquiring large amounts high-quality labelled remains, many researchers have begun use semi-supervised learning methods learn unlabeled data. Although current models partially solve issue limited data, they inefficient exploiting samples. To address this, we introduce new AI-assisted scheme, Reliable-Unlabeled Semi-Supervised Segmentation (RU3S) model. model integrates ResUNet-SE-ASPP-Attention (RSAA) model, which includes Squeeze-and-Excitation (SE) network, Atrous Spatial Pyramid Pooling (ASPP) structure, Attention module, ResUNet architecture. Our leverages effectively, improving accuracy significantly. A novel confidence filtering strategy introduced make better samples, addressing scarcity Experimental results show 2.0% improvement mIoU over state-of-the-art segmentation ST, demonstrating our approach's effectiveness solving this problem.

Язык: Английский

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