Tracking Survivors With Long COVID: Method, Implementation, and Results of an Observational Study

Research in Nursing & Health, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

While the coronavirus disease 2019 (COVID-19) pandemic has declined, many survivors continue to suffer debilitating symptoms, such as fatigue, pain, and foggy thoughts. Sustained COVID-19 or Long COVID, challenge health care resources economic recovery. This article describes methodology, implementation, results of an observational study investigating how time since diagnosis may affect lingering symptoms among adult population. The descriptive distribution overall experience by individuals' characteristics were examined. Random samples from two patient cohorts (n = 147 in 2020-2021 n 137 2021-2022) recruited a registry mid-Michigan. Samples drawn pool patients ≥ 3 months following their diagnosis. Overall (number, severity, interference) was self-reported using comprehensive symptom inventory. findings showed that 66% cohort 47% 2021-2022 reported 1 with average 11.2 (±3.0) 8.9 (±3.3) months, respectively, after Females significantly more (p 0.018), higher severity 0.008) interference 0.007) compared males. Compared admitted emergency departments, outpatients lower 0.020) less 0.018). Our analyses moderate proportion (43%) adults remained symptomatic nearly year infection did not either cohort. Female sex admission setting are important factors consider for managing studying COVID.

Язык: Английский

---

Environmental Pollution in Biomedical and Pharmaceutical Sectors

Опубликована: Янв. 1, 2025

Язык: Английский

---

Nanotherapeutics in COVID-19 and associated pulmonary infections

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 371 - 400

Опубликована: Янв. 1, 2025

Язык: Английский

---

The Impact of Prior COVID-19 on Long-Term Mortality and Echocardiographic Predictors in Chronic Kidney Disease Patients

Diagnostics, Год журнала: 2025, Номер 15(6), С. 678 - 678

Опубликована: Март 10, 2025

Background/Objectives: Chronic kidney disease (CKD) patients are at an increased risk for severe outcomes following a COVID-19 infection. However, the long-term impact of prior on survival in this population remains unclear. This study evaluates association between infection, echocardiographic parameters, and mortality CKD over 24-month follow-up period. Methods: A prospective cohort was conducted 239 patients, including those hemodialysis. Kaplan–Meier analysis Cox proportional hazards models were used to assess COVID-19, age, comorbidities rate. mediation examined role age parameters relationship. Results: curves demonstrated significantly lower probability group compared controls (72.5% vs. 87.1%, p = 0.01), particularly hemodialysis (62.5% 83.8%, 0.01). In contrast, no significant difference observed non-dialysis (p 0.52). multivariate confirmed as key mediator, with losing significance after adjustment 0.05). An identified left right ventricular dysfunction independent predictors, partially mediating COVID-19–mortality Conclusions: reduces rate while strong predictors mortality. Age mediates relationship mortality, but factor. These findings underscore need cardiac function monitoring post-COVID-19 improve outcomes.

Язык: Английский

---

Unveiling the journey: a deep dive into healthcare workers’ preparation, concerns, and experiences with the COVID-19 vaccine- a qualitative study

International Journal of Research in Medical Sciences, Год журнала: 2025, Номер 13(4), С. 1504 - 1513

Опубликована: Март 29, 2025

Background: The COVID pandemic had a profound impact on human life globally and presents an unprecedented challenge to public health, food systems, the world of work. vaccine is considered as safe effective for minimising COVID-19. However, related adverse event one major reason scepticism. Therefore, this study intended explore post effects concerns among HCWs. Methods: A qualitative exploratory was conducted HCWs tertiary care centre, eastern India, who developed within 7 days receipt vaccine. Information collected by using indepth interview guide from 12 health professionals. Then, data transcribed, systematically coded analyzed following thematic framework approach MAXQDA-2020 software. Results: After analysis four main themes were emerged: vaccination perception readiness; aftermath; management effects; suggestions. Respondents across demographic group depicted varied experiences like they received motivate other, be part research vaccination. most common reported events wererange headache, body ache, fever, altered taste, dizziness hyperglycemia, irregular heart rate, diarrhoea dyspnea. Moreover, their experience first dose convinced them prepare 2nd with taking adequate fruit, water rest. Conclusions: Knowledge about people’s lived after receiving COVID-19 can used formulate strategies awareness programmes enhance uptake in future.

Язык: Английский

---

Global COVID-19 Vaccination Challenges: Inequity of Access and Vaccine Hesitancy

Journal of Medicine Surgery and Public Health, Год журнала: 2025, Номер unknown, С. 100197 - 100197

Опубликована: Апрель 1, 2025

Язык: Английский

---

Adverse childhood experiences and chronic health outcomes: evidence from 33 US states in the Behavioral Risk Factor Surveillance System, 2019-2023

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Май 5, 2025

Recent evidence suggests a significant association between adverse childhood experience (ACE) and chronic health outcomes among U.S. adults. However, there remains critical need to explore these associations specifically with respect racial disparities. Early adversity preexisting vulnerabilities may interact, compounding the risk of diseases in historically marginalized populations. This study further explored relationship ACE disease, recognizing that ACEs exert more pronounced effect ethnic groups already at elevated risk. To investigate this relationship, subgroup analysis was conducted variations by race ethnicity. We analyzed data from Behavioral Risk Factor Surveillance System (BRFSS) collected 33 states 2019 2023. scores were categorized as none, low (1-2), or high (3+). Log-binomial regression assessed 17 outcomes. Subgroup analyses examined variation race/ethnicity, geographic patterns summarized state. All accounted for age, sex, income, education. Of 359,507 participants, 24.4% reported exposure. Emotional abuse, parental separation, household substance abuse most ACEs. Individuals exposure had higher risks depression, smoking, coronary heart other conditions. Racial disparities evident analysis. While white respondents significantly associated many outcomes, races/ethnicities often demonstrated ratios when significant. Particularly, AIAN showed highest national-level conditions such attack, stroke. Geographically, prevalence health-related varied state, Oregon Nevada exhibiting mean scores. High are disease mental issues. These findings highlight its impacts. Addressing holistically considering state-related factors predisposed racial/ethnic is an emerging need. State-level policies focused on trauma prevention, particularly vulnerable high-risk areas, help implement interventions tailored address unique diverse

Язык: Английский

---

Guinea Pigs Are Not a Suitable Model to Study Neurological Impacts of Ancestral SARS-CoV-2 Intranasal Infection

Viruses, Год журнала: 2025, Номер 17(5), С. 706 - 706

Опубликована: Май 15, 2025

Neurological symptoms involving the central nervous system (CNS) and peripheral (PNS) are common complications of acute COVID-19 as well post-COVID conditions. Most research into these neurological sequalae focuses on CNS, disregarding PNS. Guinea pigs were previously shown to be useful models disease during SARS-CoV-1 epidemic. However, their suitability for studying SARS-CoV-2 has not been experimentally demonstrated. To assess guinea infection impact PNS, determine routes CNS invasion through we intranasally infected wild-type Dunkin-Hartley with ancestral USA-WA1/2020. We assessed PNS sensory neurons (trigeminal ganglia, dorsal root ganglia), autonomic (superior cervical brain regions (olfactory bulb, brainstem, cerebellum, cortex, hippocampus), lungs, blood viral RNA (RT-qPCR), protein (immunostaining), infectious virus (plaque assay) at three- six-days post infection. show that pigs, which have used a model pulmonary disease, susceptible intranasal SARS-CoV-2, in assessing impacts isolates from early pandemic.

Язык: Английский

---

Laboratory Findings and Biomarkers in Long COVID: What Do We Know So Far? Insights Into Epidemiology, Pathogenesis, Therapeutic Perspectives and Challenges

Опубликована: Май 22, 2023

Long COVID (LC) encompasses a constellation of long-term symptoms experienced by at least 10% people after the initial SARS-CoV-2 infection, and so far has affected about 65 million people. The etiology LC remains unclear; however, many pathophysiological pathways may be involved, including viral persistence; chronic, low grade inflammatory response; immune dysregulation defective reactivation latent viruses; autoimmunity; persistent endothelial dysfunction coagulopathy; gut dysbiosis; hormonal dysregulation, mitochondrial dysfunction; autonomic nervous system dysfunction. There are no specific tests for diagnosis LC, clinical features laboratory findings biomarkers not specifically relate to LC. Therefore, it is paramount importance develop validate that can employed prediction, prognosis its therapeutic response. Promising candidate found in some patients markers systemic inflammation acute phase proteins, cytokines chemokines; reflecting persistence, herpesviruses dysregulation; endotheliopathy, coagulation fibrinolysis; microbiota alterations; diverse proteins metabolites; metabolic biomarkers; as well cerebrospinal fluid biomarkers. At present, there only two reviews summarizing relevant they do cover entire umbrella current or their link etiopathogenetic mechanisms, diagnostic work-up comprehensive manner. Herein, we aim appraise synopsize available evidence on typical manifestations classification based main symptomatology frame epidemiological pathogenetic aspects syndrome, furthermore assess limitations challenges potential implications interventions.

Язык: Английский

---

Challenges and Solutions during the COVID-19 Pandemic: Hospitalization and Performance in Elective Pediatric Surgeries

Medicina, Год журнала: 2024, Номер 60(7), С. 1072 - 1072

Опубликована: Июнь 29, 2024

: This retrospective study aimed to investigate the impact of COVID-19 pandemic on most frequently performed elective pediatric surgical procedures and number hospitalizations compare it pre-pandemic post-pandemic periods.

Язык: Английский

---