Environmental Pollution in Biomedical and Pharmaceutical Sectors

Published: Jan. 1, 2025

Language: Английский

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Nanotherapeutics in COVID-19 and associated pulmonary infections

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 371 - 400

Published: Jan. 1, 2025

Language: Английский

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The Impact of Prior COVID-19 on Long-Term Mortality and Echocardiographic Predictors in Chronic Kidney Disease Patients

Diagnostics, Journal Year: 2025, Volume and Issue: 15(6), P. 678 - 678

Published: March 10, 2025

Background/Objectives: Chronic kidney disease (CKD) patients are at an increased risk for severe outcomes following a COVID-19 infection. However, the long-term impact of prior on survival in this population remains unclear. This study evaluates association between infection, echocardiographic parameters, and mortality CKD over 24-month follow-up period. Methods: A prospective cohort was conducted 239 patients, including those hemodialysis. Kaplan–Meier analysis Cox proportional hazards models were used to assess COVID-19, age, comorbidities rate. mediation examined role age parameters relationship. Results: curves demonstrated significantly lower probability group compared controls (72.5% vs. 87.1%, p = 0.01), particularly hemodialysis (62.5% 83.8%, 0.01). In contrast, no significant difference observed non-dialysis (p 0.52). multivariate confirmed as key mediator, with losing significance after adjustment 0.05). An identified left right ventricular dysfunction independent predictors, partially mediating COVID-19–mortality Conclusions: reduces rate while strong predictors mortality. Age mediates relationship mortality, but factor. These findings underscore need cardiac function monitoring post-COVID-19 improve outcomes.

Language: Английский

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Unveiling the journey: a deep dive into healthcare workers’ preparation, concerns, and experiences with the COVID-19 vaccine- a qualitative study

International Journal of Research in Medical Sciences, Journal Year: 2025, Volume and Issue: 13(4), P. 1504 - 1513

Published: March 29, 2025

Background: The COVID pandemic had a profound impact on human life globally and presents an unprecedented challenge to public health, food systems, the world of work. vaccine is considered as safe effective for minimising COVID-19. However, related adverse event one major reason scepticism. Therefore, this study intended explore post effects concerns among HCWs. Methods: A qualitative exploratory was conducted HCWs tertiary care centre, eastern India, who developed within 7 days receipt vaccine. Information collected by using indepth interview guide from 12 health professionals. Then, data transcribed, systematically coded analyzed following thematic framework approach MAXQDA-2020 software. Results: After analysis four main themes were emerged: vaccination perception readiness; aftermath; management effects; suggestions. Respondents across demographic group depicted varied experiences like they received motivate other, be part research vaccination. most common reported events wererange headache, body ache, fever, altered taste, dizziness hyperglycemia, irregular heart rate, diarrhoea dyspnea. Moreover, their experience first dose convinced them prepare 2nd with taking adequate fruit, water rest. Conclusions: Knowledge about people’s lived after receiving COVID-19 can used formulate strategies awareness programmes enhance uptake in future.

Language: Английский

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Global COVID-19 Vaccination Challenges: Inequity of Access and Vaccine Hesitancy

Journal of Medicine Surgery and Public Health, Journal Year: 2025, Volume and Issue: unknown, P. 100197 - 100197

Published: April 1, 2025

Language: Английский

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Adverse childhood experiences and chronic health outcomes: evidence from 33 US states in the Behavioral Risk Factor Surveillance System, 2019-2023

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 5, 2025

Recent evidence suggests a significant association between adverse childhood experience (ACE) and chronic health outcomes among U.S. adults. However, there remains critical need to explore these associations specifically with respect racial disparities. Early adversity preexisting vulnerabilities may interact, compounding the risk of diseases in historically marginalized populations. This study further explored relationship ACE disease, recognizing that ACEs exert more pronounced effect ethnic groups already at elevated risk. To investigate this relationship, subgroup analysis was conducted variations by race ethnicity. We analyzed data from Behavioral Risk Factor Surveillance System (BRFSS) collected 33 states 2019 2023. scores were categorized as none, low (1-2), or high (3+). Log-binomial regression assessed 17 outcomes. Subgroup analyses examined variation race/ethnicity, geographic patterns summarized state. All accounted for age, sex, income, education. Of 359,507 participants, 24.4% reported exposure. Emotional abuse, parental separation, household substance abuse most ACEs. Individuals exposure had higher risks depression, smoking, coronary heart other conditions. Racial disparities evident analysis. While white respondents significantly associated many outcomes, races/ethnicities often demonstrated ratios when significant. Particularly, AIAN showed highest national-level conditions such attack, stroke. Geographically, prevalence health-related varied state, Oregon Nevada exhibiting mean scores. High are disease mental issues. These findings highlight its impacts. Addressing holistically considering state-related factors predisposed racial/ethnic is an emerging need. State-level policies focused on trauma prevention, particularly vulnerable high-risk areas, help implement interventions tailored address unique diverse

Language: Английский

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Guinea Pigs Are Not a Suitable Model to Study Neurological Impacts of Ancestral SARS-CoV-2 Intranasal Infection

Viruses, Journal Year: 2025, Volume and Issue: 17(5), P. 706 - 706

Published: May 15, 2025

Neurological symptoms involving the central nervous system (CNS) and peripheral (PNS) are common complications of acute COVID-19 as well post-COVID conditions. Most research into these neurological sequalae focuses on CNS, disregarding PNS. Guinea pigs were previously shown to be useful models disease during SARS-CoV-1 epidemic. However, their suitability for studying SARS-CoV-2 has not been experimentally demonstrated. To assess guinea infection impact PNS, determine routes CNS invasion through we intranasally infected wild-type Dunkin-Hartley with ancestral USA-WA1/2020. We assessed PNS sensory neurons (trigeminal ganglia, dorsal root ganglia), autonomic (superior cervical brain regions (olfactory bulb, brainstem, cerebellum, cortex, hippocampus), lungs, blood viral RNA (RT-qPCR), protein (immunostaining), infectious virus (plaque assay) at three- six-days post infection. show that pigs, which have used a model pulmonary disease, susceptible intranasal SARS-CoV-2, in assessing impacts isolates from early pandemic.

Language: Английский

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Relations between Video Game Engagement and Social Development in Children: The Mediating Role of Executive Function and Age-Related Moderation

Behavioral Sciences, Journal Year: 2023, Volume and Issue: 13(10), P. 833 - 833

Published: Oct. 11, 2023

The global proliferation of video games, particularly among children, has led to growing concerns about the potential impact on children's social development. Executive function is a cognitive ability that plays crucial role in development, but child's age constrains its To examine association between game engagement and development while considering mediating executive moderating age, questionnaire was distributed sample 431 parents. results revealed negative relation with found mediate this fully. Additionally, became more pronounced as children grew older. In light these findings, it advisable adopt proactive strategies limit excessive use, consider developmental characteristics at different ages, prioritize promotion facilitate children.

Language: Английский

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Laboratory Findings and Biomarkers in Long COVID: What Do We Know So Far? Insights Into Epidemiology, Pathogenesis, Therapeutic Perspectives and Challenges

Published: May 22, 2023

Long COVID (LC) encompasses a constellation of long-term symptoms experienced by at least 10% people after the initial SARS-CoV-2 infection, and so far has affected about 65 million people. The etiology LC remains unclear; however, many pathophysiological pathways may be involved, including viral persistence; chronic, low grade inflammatory response; immune dysregulation defective reactivation latent viruses; autoimmunity; persistent endothelial dysfunction coagulopathy; gut dysbiosis; hormonal dysregulation, mitochondrial dysfunction; autonomic nervous system dysfunction. There are no specific tests for diagnosis LC, clinical features laboratory findings biomarkers not specifically relate to LC. Therefore, it is paramount importance develop validate that can employed prediction, prognosis its therapeutic response. Promising candidate found in some patients markers systemic inflammation acute phase proteins, cytokines chemokines; reflecting persistence, herpesviruses dysregulation; endotheliopathy, coagulation fibrinolysis; microbiota alterations; diverse proteins metabolites; metabolic biomarkers; as well cerebrospinal fluid biomarkers. At present, there only two reviews summarizing relevant they do cover entire umbrella current or their link etiopathogenetic mechanisms, diagnostic work-up comprehensive manner. Herein, we aim appraise synopsize available evidence on typical manifestations classification based main symptomatology frame epidemiological pathogenetic aspects syndrome, furthermore assess limitations challenges potential implications interventions.

Language: Английский

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Impact of influenza vaccination history in the clinical course of older adults hospitalized with COVID-19

Medicina Clínica, Journal Year: 2024, Volume and Issue: 162(10), P. 477 - 482

Published: Feb. 10, 2024

Language: Английский

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