Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance in Children: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study

Advances in Therapy, Год журнала: 2024, Номер 41(4), С. 1496 - 1511

Опубликована: Фев. 16, 2024

Supplementation with dietary neuro-pigments lutein (L) and zeaxanthin (Z) has been shown to improve many aspects of visual cognitive function in adults. In this study, we tested whether a similar intervention could such outcomes preadolescent children. Sixty children (age range 5–12 years) were randomized 2:1 ratio double-blind, placebo-controlled clinical trial. Subjects supplemented gummies containing either combination 10 mg 2 (LZ) or placebo for 180 days. Macular pigment optical density (MPOD) was the primary endpoint. The secondary endpoints included serum levels L Z, brain-derived neurotrophic factor (BDNF), critical flicker fusion (CFF), eye strain fatigue using analogue scales (VAS), Children's Sleep Habits Questionnaire-Abbreviated (CSHQ-A), Creyos Health domains like attention, focus/concentration, episodic memory learning, visuospatial working memory, processing speed. Safety assessed throughout study on basis physical examination, vital signs, laboratory tests, monitoring adverse events. LZ group showed significant increases MPOD at all visits post-supplementation, as early day 42 compared placebo. levels, reduced fatigue, improved performance (focus, memory) days 90 Further, speed processing, Z BDNF No safety concerns observed. Supplementing resulted increased along L, BDNF. These changes associated performances reduction receiving gummies. investigational product safe well tolerated. http://ctri.nic.in/ Identifier CTRI/2022/05/042364.

Язык: Английский

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Association between sleep duration and myopia among Chinese children during the COVID-19 pandemic: A cross-sectional study

Frontiers in Public Health, Год журнала: 2023, Номер 10

Опубликована: Янв. 9, 2023

The studies on the association between sleep duration and myopia are limited, evidence is inconsistent. This study aimed to evaluate myopia, cycloplegic spherical equivalent (SE) axial length (AL) among Chinese children during Corona Virus Disease 2019 (COVID-19) pandemic. was a cross-sectional aged 6-18 years. comprehensive ophthalmic examinations for included SE, AL, standardized questionnaires. questionnaire duration, parental outdoor time, continuous near work without breaks. Myopia defined as SE ≤-0.50 diopters (D). A total of 1,140 were in analyses, with 84.7% myopic 74.4% children's daily being more than 8 h/d. In univariate regression analysis, compared < h/d, 8-9 >9 h/d less (p 0.01 all), had shorter AL all). After adjusting age, gender, breaks, not associated > 0.05 showed related COVID-19 pandemic-related lifestyles, but no independent association.

Язык: Английский

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Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Март 13, 2024

Abstract Background Experiences during childhood and adolescence have enduring impacts on physical mental well-being, overall quality of life, socioeconomic status throughout one’s lifetime. This underscores the importance prioritizing health children adolescents to establish an impactful healthcare system that benefits both individuals society. It is crucial for providers policymakers examine relationship between COVID-19 adolescents, as this understanding will guide creation interventions policies long-term management virus. Methods In umbrella review (PROSPERO ID: CRD42023401106), systematic reviews were identified from Cochrane Database Systematic Reviews; EMBASE (OvidSP); MEDLINE (OvidSP) December 2019 February 2023. Pairwise single-arm meta-analyses extracted included reviews. The methodological appraisal was completed using AMSTAR-2 tool. Single-arm re-presented under six domains associated with condition. classified into five according evidence classification criteria. Rosenberg’s FSN calculated binary continuous measures. Results We 1551 301 pairwise 124 met our predefined criteria inclusion. focus meta-analytical predominantly outcomes COVID-19, encompassing study designs. However, rigor suboptimal. Based gathered meta-analyses, we constructed illustrative representation disease severity, clinical manifestations, laboratory radiological findings, treatments, 2020 2022. Additionally, discovered 17 instances strong or highly suggestive concerning long-COVID, pediatric comorbidity, vaccines, health, depression. Conclusions findings advocate implementation surveillance systems track consequences establishment multidisciplinary collaborative rehabilitation programs affected younger populations. future research endeavors, it important prioritize investigation non-physical bridge gap application in field.

Язык: Английский

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Atropine Ophthalmic Solution to Reduce Myopia Progression in Pediatric Subjects: The Randomized, Double-Blind Multicenter Phase II APPLE Study

Asia-Pacific Journal of Ophthalmology, Год журнала: 2023, Номер 12(4), С. 370 - 376

Опубликована: Май 19, 2023

The purpose of this study was to assess the dose-response effects low-dose atropine on myopia progression and safety in pediatric subjects with mild-to-moderate myopia.This phase II, randomized, double-masked, placebo-controlled compared efficacy 0.0025%, 0.005%, 0.01% placebo 99 children, aged 6-11 years, myopia. Subjects received 1 drop each eye at bedtime. primary endpoint change spherical equivalent (SE), while secondary endpoints included changes axial length (AL) near logMAR (logarithm minimum angle resolution) visual acuity adverse effects.The mean±SD SE from baseline 12 months groups were -0.55±0.471, -0.55±0.337, -0.33±0.473, -0.39±0.519 D, respectively. least squares mean differences (atropine-placebo) 0.11 D (P=0.246), 0.23 (P=0.009), 0.25 (P=0.006), Compared placebo, AL significantly greater for 0.005% (-0.09 mm, P=0.012) (-0.10 P=0.003). There no significant any treatment groups. most common ocular events pruritus blurred vision, occurring 4 (5.5%) atropine-treated children. Changes pupil size amplitude accommodation minimal.Atropine doses effectively reduced children but effect noted 0.0025%. All safe well tolerated.

Язык: Английский

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From evidence to action: public health approaches to reducing screen time and mitigating myopia risk

Asia-Pacific Journal of Ophthalmology, Год журнала: 2025, Номер unknown, С. 100177 - 100177

Опубликована: Фев. 1, 2025

The global burden of myopia continues to expand, and the prevalence in East Asian populations is particular concern. With substantial increase screen-based electronic devices, screen time has emerged as a potential risk factor. This review examined relationship between viewing duration public health strategies reduce exposure among children. We conducted an evidence-based only meta-analyses investigating association, searching PubMed from inception January 20, 2025. Four six reviewed supported association prolonged use (> 2 or 3hours/day) increased risk. However, methodological limitations include predominance cross-sectional study designs, self-reported measurements, lack cycloplegic refraction some studies within meta-analyses. Current focus mainly on banning mobile phones schools limiting time. Technology-based solutions, such anti-addiction systems, support complement these strategies. Healthcare providers play crucial role assessing patterns children providing recommendations. Future should employ objective conduct longitudinal analyses with refraction, evaluate effectiveness interventions prevention through randomized controlled trials. In addition, examining combined effects traditional near-work activities may provide more comprehensive insights into factors.

Язык: Английский

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Prevalence of fundus changes in healthy school-aged children and adolescents aged 5–19 years in Beijing

Eye, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Язык: Английский

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Myopia control using a modified optical defocus soft contact lens in schoolchildren—A 12‐month randomised double masked control trial

Ophthalmic and Physiological Optics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Defocus Incorporated Soft Contact (DISC) lenses with +2.50 D myopic defocus reduced myopia progression by 25% in a previous randomised clinical trial (RCT). The current study aimed to evaluate if stronger defocus, +3.50 variable (DISC3.5plus), could slow compared single vision (SV) soft contact 12-month RCT. Conducted from December 2018 January 2021, the RCT randomly assigned children wear DISC3.5plus (n = 87) or SV 80) lenses. Myopia and axial elongation were between two groups. Analyses performed for both enrolled completed participants. For all participants, group had significantly less (mean difference: -0.15 ± 0.07 D, p 0.02) 0.04 0.02 0.04) than at 6 months but not 12 (myopia progression: 0.11; elongation: 0.13). 33) (0.25 0.001) (0.19 0.09 0.049) 40), (6 months: 0.16; 0.32). In 2020, coronavirus pandemic disturbed lens-wearing patterns. slowed participants over months. hindered longer term efficacy follow-up sample size; thus, further investigation more is needed confirm sustained treatment effects.

Язык: Английский

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Myopia Progression during the COVID-19 Era: A Systematic Review and Meta-analysis

Seminars in Ophthalmology, Год журнала: 2023, Номер 38(6), С. 537 - 546

Опубликована: Фев. 2, 2023

Background To evaluate myopia progression during the novel coronavirus disease 2019 (COVID-19) pandemic and its risk factors.

Язык: Английский

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Baseline metrics that may predict future myopia in young children

Ophthalmic and Physiological Optics, Год журнала: 2023, Номер 43(3), С. 466 - 481

Опубликована: Март 9, 2023

Abstract Purpose We used baseline data from the PICNIC longitudinal study to investigate structural, functional, behavioural and heritable metrics that may predict future myopia in young children. Methods Cycloplegic refractive error (M) optical biometry were obtained 97 children with functional emmetropia. Children classified as high risk (HR) or low (LR) for based on parental M. Other included axial length (AXL), length/corneal radius (AXL/CR) centile curves. Results Based criteria, 46 (26 female) HR (M = +0.62 ± 0.44 D, AXL 22.80 0.64 mm) 51 (27 LR +1.26 22.77 0.77 mm). centiles, 49 HR, moderate agreement compared classification (k 0.65, p < 0.01). ANCOVA age a covariate showed significant effect ( 0.01), longer deeper anterior chamber depth (ACD) 0.01) those at (differences 0.16 mm, ACD 0.13 Linear regression models central corneal thickness (CCT), ACD, posterior vitreous (PVD) (=AXL – CCT ACD‐lens (LT)), (CR) significantly predicted M R 0.64, Each 1.00 D decrease hyperopia was associated 0.97 mm elongation PVD 0.43 increase CR. The ratio AXL/CR −0.45, did −0.25, although lesser extent. Conclusions Although highly correlated, of pre‐myopic into different when using each parameter, being most predictive metric. At end study, we will be able assess predictability

Язык: Английский

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Challenges of refractive cataract surgery in the era of myopia epidemic: a mini-review

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Сен. 19, 2023

Myopia is the leading cause of visual impairment in world. With ever-increasing prevalence these years, it creates an alarming global epidemic. In addition to difficulty seeing distant objects, myopia also increases risk cataract and advances its onset, greatly affecting productivity myopes working age. Cataract management myopic eyes, especially highly eyes originally more complicated than that normal whereas growing population with myopia, increasing popularity corneal lens based refractive surgery, rising demand for spectacle independence after surgery all further pose unprecedented challenges ophthalmologists. Previous history existence implantable collamer will both affect accuracy biometry including measurement curvature axial length before which may result larger intraocular (IOL) power prediction errors a compromise surgical outcome surgery. A prudent choice formula patients different characteristics essential improving this condition. Besides, might long-term stability IOL, important maintenance outcomes implantation premium IOLs, thus proper selection IOL accordingly crucial. mini-review, we provide overview impact epidemic on treatment discuss new surgeons encounter foreseeable future when planning patients.

Язык: Английский

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