OCCUPATIONAL EXPOSURE TO PESTICIDES AFFECTS SYSTEMIC CYTOKINE PROFILE AND CORRELATES WITH POOR CLINICAL PROGNOSIS IN YOUNG WOMEN WITH BREAST CANCER DOI
Rafael Cardoso Maciel Costa Silva, Tatiane Renata Fagundes, Carolina Coradi

и другие.

Immunopharmacology and Immunotoxicology, Год журнала: 2024, Номер unknown, С. 1 - 13

Опубликована: Ноя. 25, 2024

Aging is one of the main risk factors for breast cancer. However, impact environmental factors, such as pesticide exposure, on clinical outcomes patients with cancer, depending disease onset, remains unclear. This study analyzed clinicopathological data from 188 women who were either occupationally or domestically exposed to pesticides, not exposed, according their age at onset (early ≤ 50 years and late > years). Additionally, interleukin 4 (IL-4), 17A (IL-17A), 12 (IL-12) levels measured in plasma samples, assessed. In late-onset group, a greater frequency low-grade tumors was detected compared unexposed group (23.14% vs. 45.45%, p = 0.0181). A higher high-risk stratification recurrence death found early-onset when comparing groups (10.0% 30.0%, 0.0488). Regarding molecular subtypes showed triple-negative than same (20.0% 40.63%, < 0.0001). IL-12 significantly lower group. Early-onset principal component that positively correlated IL-1β, IL-17A, IL-4, while negative correlations between exposure IL-12, IL-17A. These findings suggest induces an inflammaging-like state younger women, contributing increased developing more severe disease.

Язык: Английский

Pesticide exposure and increased breast cancer risk in women population studies DOI Creative Commons
Carolina Panis,

Bernardo Lemos

The Science of The Total Environment, Год журнала: 2024, Номер 933, С. 172988 - 172988

Опубликована: Май 4, 2024

Pesticide exposure is emerging as a risk factor for various human diseases. Breast cancer (BC) multifactorial disease with known genetic and non-genetic factors. Most BC cases are attibutable to factors, history of adverse environmental exposures playing significant role. can occur at higher levels in female populations participating rural activities such spraying pesticides the field, unprotected handling home, washing contaminated clothes. Exposure also be drinking water certain populations. Here, we reviewed literature on women's BC. We summarize main links between pesticide discuss role dose, context, potential mechanisms. Overall, reports here have documented stronger associations risk, including documenting direct acute However, discrepancies among studies regarding dose mode may result misunderstandings about risks posed by exposure. Plausible mechanisms linking breast include impacts endocrine disruptors, well roles genotoxic agents, modulators epigenome. Besides establishing cancer, highlights critical need understand routes doses specific that determinants etiology prognosis.

Язык: Английский

Процитировано

8
Factors associated with recurrence in operable breast cancer patients undergoing surgery as the sole treatment modality DOI Creative Commons
Maressa Daniela Anghinoni Bonissoni, Fernanda Mara Alves, Rafaella Frederico Almeida

и другие.

Acta Cirúrgica Brasileira, Год журнала: 2025, Номер 40

Опубликована: Янв. 1, 2025

ABSTRACT Purpose: Approximately 10% of breast cancer patients with localized operable disease experience recurrence. This study aimed to evaluate early-stage (TNM I and II) who underwent surgery without the need for neoadjuvant therapy. Methods: The total 117 was included in study: 104 recurrence 13 We analyzed various clinicopathological parameters, including body mass index, age at diagnosis, menopausal status, pesticide exposure, tumor characteristics such as HER2 amplification, Ki67 molecular subtype, histological grade. Results: Two primary subsets were identified being associated first subset (PC1) characterized by amplification metastatic disease, while second (PC2) comprised premenopausal young women exposed pesticides had triple-negative tumors. While some these factors are well-documented literature, exposure emerged a notable regional factor contributing poor outcomes patients. Conclusion: These findings underscored significance identifying local risk when assessing cancer, particularly cases which is treatment approach.

Язык: Английский

Процитировано

0
Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients DOI Creative Commons
Stephany Bonin Godinho dos Santos, Janaína Carla da Silva, Hellen dos Santos Jaques

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Окт. 24, 2023

Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined circulating cytokine profile Th1/Th2/Th17 patterns women occupationally pesticides and their correlation with worse prognostic outcomes. Peripheral blood samples were collected from 187 rural working cancer, or not pesticides, quantify levels cytokines IL-1β, IL-12, IL-4, IL-17-A, TNF -α. Data disease clinical outcomes through medical follow-up. IL-12 was reduced tumors larger than 2 cm those lymph node metastases. Significantly IL-17A observed patients Luminal B subtype tumors, high ki67 proliferation rates, histological grade, positive for progesterone receptor. Reduced IL-4 also seen invasion. Our data show that occupational exposure induces significant changes necessary tumor control correlates poor

Язык: Английский

Процитировано

5
Occupational pesticide exposure is linked to the prevalence of Luminal B breast cancer and poor prognosis features in Brazilian rural women DOI Creative Commons

Isabella Cazagranda,

Rafaela de Almeida,

Lucca L. Smaniotto

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Апрель 11, 2024

Abstract Brazil is among the top three global consumers of pesticides, despite evidence concerning negative impact on public health. The exposure female rural workers has been neglected, and incidence pesticide-induced diseases such as breast cancer growing. In this context, study analyzed occupational/household pesticide clinicopathological profile in women. Clinicopathological data were collected from medical records a total 386 patients (208 exposed 141 unexposed to pesticides). Was used descriptive inferential statistics methods characterize patient data, including chi-square test Fisher's exact test, evaluate associations between variables. This was grouped patient, tumor, disease characteristics. Exposed had prevalence Luminal B subtype (32.83%), while A molecular (37.78%). also higher recurrence (10.19%), chemoresistance (21.26%), death occurrence (7.21%) than patients. Breast pesticides more likely have distant metastases lymph node invasion compared These findings indicate that favors aggressive women through occupational exposure. results information could be added screening process risk determination for severity.

Язык: Английский

Процитировано

0
OCCUPATIONAL EXPOSURE TO PESTICIDES AFFECTS SYSTEMIC CYTOKINE PROFILE AND CORRELATES WITH POOR CLINICAL PROGNOSIS IN YOUNG WOMEN WITH BREAST CANCER DOI
Rafael Cardoso Maciel Costa Silva, Tatiane Renata Fagundes, Carolina Coradi

и другие.

Immunopharmacology and Immunotoxicology, Год журнала: 2024, Номер unknown, С. 1 - 13

Опубликована: Ноя. 25, 2024

Aging is one of the main risk factors for breast cancer. However, impact environmental factors, such as pesticide exposure, on clinical outcomes patients with cancer, depending disease onset, remains unclear. This study analyzed clinicopathological data from 188 women who were either occupationally or domestically exposed to pesticides, not exposed, according their age at onset (early ≤ 50 years and late > years). Additionally, interleukin 4 (IL-4), 17A (IL-17A), 12 (IL-12) levels measured in plasma samples, assessed. In late-onset group, a greater frequency low-grade tumors was detected compared unexposed group (23.14% vs. 45.45%, p = 0.0181). A higher high-risk stratification recurrence death found early-onset when comparing groups (10.0% 30.0%, 0.0488). Regarding molecular subtypes showed triple-negative than same (20.0% 40.63%, < 0.0001). IL-12 significantly lower group. Early-onset principal component that positively correlated IL-1β, IL-17A, IL-4, while negative correlations between exposure IL-12, IL-17A. These findings suggest induces an inflammaging-like state younger women, contributing increased developing more severe disease.

Язык: Английский

Процитировано

0