Addressing the rising colorectal cancer burden in the older adult: examining modifiable risk and protective factors for comprehensive prevention strategies
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 4, 2025
Colorectal
cancer
is
one
of
the
most
prevalent
and
deadly
types
worldwide.
Emerging
evidence
suggests
that
high
body
mass
index
(BMI)
a
significant
risk
factor
for
colorectal
cancer,
particularly
among
older
adult
population.
This
comprehensive
analysis
aims
to
explore
complex
epidemiological
patterns
with
focus
on
association
between
BMI
disease
burden
in
adult.
The
study
leveraged
data
from
Global
Burden
Disease
(GBD)
2021
examine
temporal
trends,
regional
disparities,
interplay
age,
period,
cohort
factors
shaping
global
landscape.
Epidemiological
techniques,
including
age-period-cohort
modeling
joinpoint
regression
analysis,
were
employed
provide
insights
into
potential
drivers
evolving
while
controlling
relevant
confounding
factors.
revealed
geographical
disparities
Countries
like
Uruguay,
Monaco,
Croatia,
Hungary,
Poland
exhibited
higher
mortality
disability-adjusted
life-year
(DALY)
rates,
regions
Bangladesh,
Nepal,
much
Africa
had
relatively
lower
burden.
These
differences
are
likely
attributable
variations
healthcare
systems,
access
screening
early
detection
programs,
as
well
lifestyle
behaviors
prevalence.
strong
risk,
population
men,
emphasizes
importance
obesity
management
strategies
part
control
efforts.
Targeted
interventions,
such
community-based
weight
programs
enhanced
initiatives
high-risk
regions,
could
help
mitigate
disproportionate
observed
countries
Hungary.
Ongoing
research
multifaceted
public
health
interventions
crucial
address
growing
impact
vulnerable
populations.
Strengthening
improving
quality
care,
promoting
modifications
reduce
other
modifiable
should
be
prioritized
effectively
combat
this
pressing
challenge.
Язык: Английский
Plant Terpenoids in Combination with Conventional Therapeutics in Colorectal Cancer: A Promising Option
Current Oncology Reports,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Язык: Английский
Gut microbiota in colorectal cancer: From pathogenesis to clinic
Best Practice & Research Clinical Gastroenterology,
Год журнала:
2024,
Номер
72, С. 101941 - 101941
Опубликована: Авг. 3, 2024
Colorectal
cancer
is
the
third
most
common
type
of
cancer,
with
a
significant
burden
on
healthcare
and
social
systems.
Its
incidence
constantly
rising,
due
to
spread
unhealthy
lifestyle,
i.e.
Western
diet.
Increasing
evidence
suggests
that
westernization-driven
microbiome
alterations
may
play
critical
role
in
colorectal
tumorigenesis.
The
current
screening
strategies
for
this
neoplasm,
mainly
fecal
immunochemical
tests,
are
burdened
by
unsatisfactory
accuracy.
Novel,
non-invasive
biomarkers
rising
as
new
frontier
screening,
microbiome-based
ones
showing
positive
optimistic
results.
This
Review
describes
our
knowledge
gut
microbiota
from
its
pathogenetic
action
clinical
potential
diagnostic
biomarker.
Язык: Английский
Obesity-Associated Colorectal Cancer
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8836 - 8836
Опубликована: Авг. 14, 2024
Colorectal
cancer
(CRC)
affects
approximately
2
million
people
worldwide.
Obesity
is
the
major
risk
factor
for
CRC.
In
addition,
obesity
contributes
to
a
chronic
inflammatory
stage
that
enhances
tumor
progression
through
secretion
of
proinflammatory
cytokines.
addition
an
increased
response,
obesity-associated
presents
accrued
molecular
factors
related
characteristics,
such
as
genome
instability,
sustained
cell
proliferation,
telomere
dysfunctions,
angiogenesis,
and
microbial
alteration,
among
others.
Despite
evidence
accumulated
over
last
few
years,
treatments
CRC
do
not
differ
from
in
normal-weight
individuals.
this
review,
we
summarize
current
knowledge
on
cancer,
including
its
epidemiology,
factors,
treatments.
Finally,
enumerate
possible
new
therapeutic
targets
may
improve
conditions
obese
patients.
key
development
CRC,
resulting
reversal
should
be
considered
strategy
improving
antineoplastic
therapies.
Язык: Английский
Cáncer Colorrectal En adultos jóvenes: Experiencia mono institucional
Oncología Clínica,
Год журнала:
2024,
Номер
29(3)
Опубликована: Дек. 16, 2024
Introducción:
El
cáncer
colorrectal
(CCR)
en
adultos
jóvenes
es
una
entidad
cada
vez
más
prevalente
y
se
estima
que
la
próxima
década
1
de
4
pacientes
sea
menor
50
años.
En
nuestro
país
existen
pocos
datos
este
subgrupo
pacientes.
Métodos:
Estudio
cohorte
retrospectivo,
atendidos
nuestra
institución,
con
CCR
confirmados
histológicamente,
desde
enero
2018
a
junio
2023
menos
años
al
momento
del
diagnóstico.
objetivo
primario
fue
describir
las
características
clínico-patológicas
moleculares
3
subgrupos:
40-49,
30-39
≤
29
Los
objetivos
secundarios
fueron
tiempo
diagnóstico,
sobrevida
global
libre
progresión
los
distintos
subgrupos.
Resultados:
Se
incluyeron
502
histología
adenocarcinoma.
59.8%
tenía
40-49
años,
34.8%
5.4%
Estadios
tempranos
(61.3%,
57.1%
59.3%)
localización
derecha
(22%,
22.8%
22.2%)
similares
sexo
femenino
el
prevalente,
siendo
mayor
(59.3%).
estatus
MMR
pudo
determinar
69.2%
déficit
proteínas
(MMRd)
comparable
entre
subgrupos,
porcentajes
8%,
11.4%
11.1%,
respectivamente.
Mutaciones
germinales
encontradas
un
20%