Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Июнь 4, 2025
Biocatalyst-mediated
reactions
have
led
to
revolutionary
transformations
in
the
organic
synthesis
of
pharmaceuticals,
drugs,
and
other
chemicals.
Nicotinic
acid
(vitamin
B3)
is
an
essential
precursor
for
nicotinamide
adenine
dinucleotide
(NAD
+
)
biosynthesis
vital
numerous
metabolic
processes.
Since
human
body
cannot
synthesize
nicotinic
acid,
it
relies
on
external
sources.
Therefore,
has
gained
huge
attraction.
In
recent
years,
industrial
production
increasingly
shifted
from
traditional
chemical
methods
more
biocatalytic
processes,
leveraging
power
biocatalysts.
This
review
highlights
biocatalyst-mediated
nicotinic-acid-
nitrile-metabolizing
enzymes
through
state-of-the-art
omics-based
techniques
improve
enzyme
catalytic
efficiency
stability
via
various
approaches.
Future
research
prospects
challenges
associated
with
are
also
discussed.
Molecules,
Год журнала:
2023,
Номер
28(18), С. 6735 - 6735
Опубликована: Сен. 21, 2023
Plants
are
constantly
exposed
to
various
phytopathogens
such
as
fungi,
Oomycetes,
nematodes,
bacteria,
and
viruses.
These
pathogens
can
significantly
reduce
the
productivity
of
important
crops
worldwide,
with
annual
crop
yield
losses
ranging
from
20%
40%
caused
by
pathogenic
diseases.
While
use
chemical
pesticides
has
been
effective
at
controlling
multiple
diseases
in
major
crops,
excessive
synthetic
chemicals
detrimental
effects
on
environment
human
health,
which
discourages
pesticide
application
agriculture
sector.
As
a
result,
researchers
worldwide
have
shifted
their
focus
towards
alternative
eco-friendly
strategies
prevent
plant
Biocontrol
is
less
toxic
safer
method
that
reduces
severity
A
variety
biological
control
agents
(BCAs)
available
for
use,
but
further
research
needed
identify
potential
microbes
natural
products
broad-spectrum
antagonistic
activity
This
review
aims
highlight
importance
biocontrol
managing
Furthermore,
role
beneficial
current
status
mechanisms
will
be
summarized.
The
also
cover
challenges
need
future
development
methods
ensure
efficient
disease
management
sustainable
agriculture.
Foods,
Год журнала:
2023,
Номер
12(11), С. 2140 - 2140
Опубликована: Май 25, 2023
Various
fields
have
been
identified
in
the
"omics"
era,
such
as
genomics,
proteomics,
transcriptomics,
metabolomics,
phenomics,
and
metagenomics.
Among
these,
metagenomics
has
enabled
a
significant
increase
discoveries
related
to
microbial
world.
Newly
discovered
microbiomes
different
ecologies
provide
meaningful
information
on
diversity
functions
of
microorganisms
Earth.
Therefore,
results
metagenomic
studies
new
microbe-based
applications
human
health,
agriculture,
food
industry,
among
others.
This
review
summarizes
fundamental
procedures
recent
advances
bioinformatic
tools.
It
also
explores
up-to-date
study,
plant
research,
environmental
sciences,
other
fields.
Finally,
is
powerful
tool
for
studying
world,
it
still
numerous
that
are
currently
hidden
awaiting
discovery.
this
discusses
future
perspectives
Plants,
Год журнала:
2023,
Номер
12(12), С. 2307 - 2307
Опубликована: Июнь 14, 2023
Microorganisms
are
an
important
element
in
modeling
sustainable
agriculture.
Their
role
soil
fertility
and
health
is
crucial
maintaining
plants'
growth,
development,
yield.
Further,
microorganisms
impact
agriculture
negatively
through
disease
emerging
diseases.
Deciphering
the
extensive
functionality
structural
diversity
within
plant-soil
microbiome
necessary
to
effectively
deploy
these
organisms
Although
both
plant
have
been
studied
over
decades,
efficiency
of
translating
laboratory
greenhouse
findings
field
largely
dependent
on
ability
inoculants
or
beneficial
colonize
maintain
stability
ecosystem.
its
environment
two
variables
that
influence
microbiome's
structure.
Thus,
recent
years,
researchers
looked
into
engineering
would
enable
them
modify
microbial
communities
order
increase
effectiveness
inoculants.
The
environments
believed
support
resistance
biotic
abiotic
stressors,
fitness,
productivity.
Population
characterization
manipulation,
as
well
identification
potential
biofertilizers
biocontrol
agents.
Next-generation
sequencing
approaches
identify
culturable
non-culturable
microbes
associated
with
expanded
our
knowledge
this
area.
Additionally,
genome
editing
multidisciplinary
omics
methods
provided
scientists
a
framework
engineer
dependable
high
yield,
resistance,
nutrient
cycling,
management
stressors.
In
review,
we
present
overview
agriculture,
engineering,
translation
technology
field,
main
used
by
laboratories
worldwide
study
microbiome.
These
initiatives
advancement
green
technologies
Microbes
found
in
soil
can
have
a
significant
impact
on
the
taste
and
quality
of
wine,
also
referred
to
as
wine
terroir.
To
date,
terroir
has
been
thought
be
associated
with
physical
chemical
characteristics
soil.
However,
there
is
fragmented
understanding
contribution
vineyard
microbes
Additionally,
vineyards
play
an
important
role
carbon
sequestration,
since
promotion
healthy
microbial
communities
directly
greenhouse
gas
emissions
atmosphere.
We
review
24
studies
that
explore
their
influence
grapevine
health,
grape
composition,
quality.
Studies
spanning
2015
2018
laid
foundation
by
exploring
biogeography
vineyards,
management
effects,
reservoir
function
for
grape-associated
microbiota.
On
other
hand,
2019
2023
appear
more
specific
targeted
approach,
delving
into
relationships
between
metabolites,
distribution
at
different
depths,
influences
flavor
composition.
Next,
we
identify
research
gaps
make
recommendations
future
work.
Specifically,
most
utilize
sequencing
(16S,
26S,
ITS)
which
only
reveals
community
Utilizing
high-throughput
omics
approaches
such
shotgun
(to
infer
function)
transcriptomics
(for
actual
vital
determine
mechanisms
chemistry.
Going
forward,
long-term
effects
practices
climate
change
microbiology,
trunk
diseases,
bacteriophages
making
would
fruitful
investigation.
Overall,
presented
shed
light
importance
microbiomes
interactions
grapevines
shaping
production.
are
still
many
aspects
this
complex
ecosystem
require
further
exploration
support
sustainable
viticulture
enhance
Panax
ginseng
cultivated
under
the
forest
is
popular
because
its
shape
and
effective
ingredients
are
similar
to
wild
ginseng.
The
growth
of
P.
in
larch
generally
better
than
broad-leaved
forest,
incidence
rate
diseases
low.
Therefore,
selection
species
one
basic
factors
successful
cropping
Abstract
Background
In
agricultural
production,
fungal
diseases
significantly
impact
the
yield
and
quality
of
cotton
(
Gossypium
spp.
)
with
Verticillium
wilt
posing
a
particularly
severe
threat.
Results
This
study
is
focused
on
investigating
effectiveness
endophytic
microbial
communities
present
in
seeds
disease-resistant
genotypes
control
wilt.
The
technique
16S
ribosomal
RNA
(16S
rRNA)
amplicon
sequencing
identified
significant
enrichment
Bacillus
genus
resistant
genotype
Xinluzao
78,
which
differed
from
bacterial
community
structure
susceptible
63.
Specific
enriched
strains
were
isolated
screened
78
to
further
explore
biological
functions
seed
endophytes.
A
synthetic
(SynCom)
was
constructed
using
broken-rod
model,
63
this
that
had
been
soaked
SynCom
found
occurrence
regulate
growth
plants.
Antibiotic
screening
techniques
used
preliminarily
identify
colonization
community.
These
revealed
can
colonize
plant
tissues
occupy
ecological
niches
through
priority
effect,
prevents
infection
by
pathogens.
Conclusion
highlights
key
role
endophytes
driving
disease
defense
provides
theoretical
basis
for
future
application
SynComs
agriculture.
