Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Toxicology, Год журнала: 2024, Номер 510, С. 154000 - 154000
Опубликована: Ноя. 17, 2024
Язык: Английский
Процитировано
2
Frontiers in Toxicology, Год журнала: 2024, Номер 6
Опубликована: Окт. 2, 2024
Neonicotinoids are the most widely used class of insecticides in United States (U.S.). and world. Consistent with their high use persistence, neonicotinoids often found contaminating drinking water food. They also detected human urine, breast milk, amniotic cerebrospinal fluids, as well brains treated rodents. were once thought to pose little neurotoxic risk humans, but a growing body research challenges that assumption. In this study we provide first comprehensive assessment unpublished rodent developmental neurotoxicity (DNT) studies on five submitted U.S. Environmental Protection Agency (EPA) by neonicotinoid manufacturers. Groups female rats administered three different doses during pregnancy lactation, offspring subjected various neurological tests brain measurements. We identified nicotine-like effects such reduced size, indicative neuronal cell loss. Statistically significant shrinkage tissue was observed high-dose for neonicotinoids: acetamiprid, clothianidin, imidacloprid, thiacloprid, thiamethoxam. Two regions studies–the corpus callosum caudate-putamen–tend be smaller people diagnosed attention-deficit hyperactivity disorder (ADHD), children mothers who smoked pregnancy, suggesting possible link between perinatal exposure ADHD. A decreased auditory startle reflex reported acetamiprid at all statistically mid- offspring, clothianidin juvenile females. No or low-dose morphometric data thiacloprid. Thiamethoxam provided EPA upon request. Only partial mid-dose morphometry no data. Yet despite lack data, concluded only treatment-related–setting study’s Observed Adverse Effect Level (NOAEL) failing find definitive NOAEL thiacloprid numerous deficiencies EPA’s regulatory oversight analyses. dismissed adverse effects, accepted substandard DNT valid positive control allowed registrants unduly influence agency decision-making. conclude metabolites induces adverse, bioassays, limits set either not protective supported available propose changes empower better protect public health from neurotoxins like neonicotinoids.
Язык: Английский
Процитировано
1
Frontiers in Toxicology, Год журнала: 2024, Номер 6
Опубликована: Авг. 13, 2024
Science evolves but outdated testing and static risk management in the US delay protection to human health
Язык: Английский
Процитировано
0
Toxicology Letters, Год журнала: 2024, Номер 399, С. S185 - S185
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
0
Reproductive Toxicology, Год журнала: 2024, Номер unknown, С. 108718 - 108718
Опубликована: Сен. 1, 2024
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Окт. 15, 2024
Abstract Zebrafish have emerged as a central model organism in toxicological research. embryos are exempt from certain animal testing regulations which facilitates their use testing. Next to the zebrafish embryo acute toxicity test (ZFET) according OECD TG 236, fish used mechanistic investigations, chemical screenings, ecotoxicology, and drug development. However, inconsistencies applied protocols monitored endpoints addition lack of standardized data formats, impede comprehensive meta-analyses cross-study comparisons. To address these challenges, we developed Integrated Effect Database for Toxicological Observations (INTOB), management tool that standardizes collection metadata phenotypic observations using controlled vocabulary. By incorporating more than 600 experiments into database subsequent analyses, demonstrate its utility improving comparability interoperability data. Our results show ZFET can detect spanning seven orders magnitude at scale effect concentrations. We also highlight potential read-across analyses based on morphological fingerprints connection modes action, provide information control variability ZFET, importance time understanding exposure-effect assessments. full FAIR dataset well analysis workflow how professional management, enabled with INTOB, marks significant advancement by offering framework systematic data, thus paving way reliable, data-driven risk assessment. Synopsis This article shows novel advances comparative assessment enhancing standardization, comparability, analyses.
Язык: Английский
Процитировано
0
Biology Methods and Protocols, Год журнала: 2024, Номер 9(1)
Опубликована: Янв. 1, 2024
Abstract The main objective of the ZebraCool programme was to create a positive attitude and curiosity towards science by bringing experimental activities within schools using an introductory cognitive sensory approach. This innovative offered at all levels primary secondary education including vocational high schools. Thematic workshops can be carried out on various themes such as comparative anatomy embryology, molecular biology evolution, or toxicology endocrine disruptors. They were ad hoc basis part annual school project zebrafish model. animal very attractive entry point for educator motivate students appreciate biology, in particular field evolution. For each practical workshop, student actor his/her learning, which intended arouse desire understand learn. based close collaboration between class teachers educators adapt workshops’ content curriculum. Students conducted their own experiments, formulated tested hypotheses, learned laboratory techniques, collected, analysed data. scientific fell conceptual framework evolutionary through participants perceived inner fish comparison biological processes humans zebrafish.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0