Evaluation Anti-porcine Reproductive and Respiratory Syndrome Virus Activity of Bacillus Strains DOI Creative Commons

Yuwei Zheng,

Hui‐Wen Chang,

Je‐Ruei Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen in the swine industry, causing severe issues pigs leading to substantial economic losses worldwide. This study investigates antiviral potential of three Bacillus strains—Bacillus amyloliquefaciens LN, Bacillus licheniformis CK, velezensis AC—against PRRSV using MARC-145 cell model. All strains demonstrated significant prophylactic direct-inhibitory effects against PRRSV, primarily through inhibition viral attachment internalization, reduction intracellular extracellular loads. Notably, cell-wall fraction AC upregulated type I IFN-dependent genes, including interferon-stimulated gene 15 (ISG15), myxovirus resistance 2 (Mx2), 2'-5'-oligoadenylate synthetase 1 (OAS1). Additionally, all significantly reduced interleukin (IL)-8 expression, with reductions tumor necrosis factor (TNF)-α levels observed specific treatments, highlighting their immune-modulatory effects. These findings suggest that have as agents offering alternative strategies for managing infections populations.

Language: Английский

Isolation and safety evaluation of food-derived potential probiotic Bacillus with antimicrobial properties DOI
Minyi Hu, Rui Jiao, Xiyan Zhang

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107338 - 107338

Published: Feb. 1, 2025

Language: Английский

Citations

0
Evaluation Anti-porcine Reproductive and Respiratory Syndrome Virus Activity of Bacillus Strains DOI Creative Commons

Yuwei Zheng,

Hui‐Wen Chang,

Je‐Ruei Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen in the swine industry, causing severe issues pigs leading to substantial economic losses worldwide. This study investigates antiviral potential of three Bacillus strains—Bacillus amyloliquefaciens LN, Bacillus licheniformis CK, velezensis AC—against PRRSV using MARC-145 cell model. All strains demonstrated significant prophylactic direct-inhibitory effects against PRRSV, primarily through inhibition viral attachment internalization, reduction intracellular extracellular loads. Notably, cell-wall fraction AC upregulated type I IFN-dependent genes, including interferon-stimulated gene 15 (ISG15), myxovirus resistance 2 (Mx2), 2'-5'-oligoadenylate synthetase 1 (OAS1). Additionally, all significantly reduced interleukin (IL)-8 expression, with reductions tumor necrosis factor (TNF)-α levels observed specific treatments, highlighting their immune-modulatory effects. These findings suggest that have as agents offering alternative strategies for managing infections populations.

Language: Английский

Citations

0