Genome-Wide Patterns of Homozygosity and Heterozygosity and Candidate Genes in Greek Insular and Mainland Native Goats DOI Open Access
Valentina Tsartsianidou,

Antonis Otapasidis,

Spiros Papakostas

и другие.

Genes, Год журнала: 2024, Номер 16(1), С. 27 - 27

Опубликована: Дек. 27, 2024

Runs of homozygosity (ROHs) and heterozygosity (ROHets) serve for the identification genomic regions as candidates selection, local adaptation, population history. The present study aimed to comprehensively explore ROH ROHet patterns hotspots in Greek native dairy goats, Eghoria Skopelos, genotyped with Illumina Goat SNP50 BeadChip. SNP functional enrichment analyses were conducted further characterize candidate genes located within these regions. Genetic relationships between breeds inbreeding coefficients also evaluated. Clear genetic differentiation diversified management practices depicted two populations. average genome coverage Skopelos (65.35 35 Mb) (47.64 43 indicated differences mainland insular showing more long fragments, reflecting its geographic isolation small size. An hotspot (CHR12: 43.59-44.61 detected has been reported across European goats co-localizes a selection signal Egyptian Barki sheep adapted hot-arid conditions. A novel (CHR18: 60.12-61.81 Mb), shared among breeds, harbors enriched biosynthesis, metabolism, immune response. Two well-conserved islands on chromosomes 1 18, participating development embryogenesis. showed highest number islands, potentially adaptability diverse environments. These findings offer new insights into environmental adaptation artificial could be utilized future breeding strategies sustainable goat farming.

Язык: Английский

Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere Goats DOI Creative Commons

Youjun Rong,

Xiaofang Ao,

Furong Guo

и другие.

Veterinary Sciences, Год журнала: 2025, Номер 12(3), С. 192 - 192

Опубликована: Фев. 20, 2025

The Inner Mongolia cashmere goat is a local breed valued for both its and meat production. Early growth traits include birth weight weaning weight. Generally, goats with higher weights tend to exhibit carcass at slaughter. Consequently, exploring the genetic variation associated these early crucial in enhancing production performance of goats. For this study, we performed genome-wide association analysis haplotype on 212 (72 rams, 140 ewes) identify molecular markers haplotypes significantly weights. Through gene annotation, identified 21 SNPs 117 candidate genes linked traits. Notably, such as RUNX1T1, ERBIN, MYO15B, NT5C, GRB2, ITGB4, GALK emerged significant factors influencing Additionally, nine blocks related were constructed, resulting eight combinations. In conclusion, combinations A1A1, C1C1, D1D1 found be beneficial improvement

Язык: Английский

Процитировано

0
Investigation of selection signatures of dairy goats using whole-genome sequencing data DOI Creative Commons

Weifeng Peng,

Yiyuan Zhang, Lei Gao

и другие.

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Март 12, 2025

Dairy goats, a livestock species with long history of milk production, are essential for the economic advancement nations, particularly in regions experiencing growth. In this study, we gathered whole-genome resequencing data 58 including 34 dairy goats and 24 wild (Bezoar), to explore selection signatures linked production traits using ROH (Runs homozygosity), CLR (composite likelihood ratio), Fst (Fixation index), XP-EHH (Ex-tended haplotype homozygosity across populations) XP-CLR(Cross-population composite ratio test) methods. Analysis five tests revealed total 210 genes, genes consistently identified at least two approaches. These associated fat, protein, fat yield. Gene enrichment analysis highlighted important GO KEGG pathways related such as "acyl-CoA metabolic process", "glycerolipid biosynthetic "cellular response fatty ac-id", "hormone "Galactose metabolism". Additionally, repro-duction, immune response, environmental adaptation were goats. The findings from our study offer profound understanding into critical features practical guidance improvement development crossbreeding initiatives different goat breeds.

Язык: Английский

Процитировано

0
Leveraging Whole-Genome Resequencing to Uncover Genetic Diversity and Promote Conservation Strategies for Ruminants in Asia DOI Creative Commons

Qinqian Wang,

Ying Lü, Mengfei Li

и другие.

Animals, Год журнала: 2025, Номер 15(6), С. 831 - 831

Опубликована: Март 13, 2025

Whole-genome resequencing (WGRS) is a critical branch of whole-genome sequencing (WGS), primarily targeting species with existing reference genomes. By aligning data to the genome, WGRS enables precise detection genetic variations in individuals or populations. As core technology genomic research, WGS holds profound significance ruminant studies. It not only reveals intricate structure genomes but also provides essential for deciphering gene function, variation patterns, and evolutionary processes, thereby advancing exploration mechanisms. However, still faces several challenges, such as incomplete inaccurate genome assembly, well annotation numerous unknown genes functions. Although can identify vast number variations, specific relationships between these phenotypes often remain unclear, which limits its potential functional studies breeding applications. performing on multiple samples, assembly challenges be effectively addressed, particularly regions high repeat content complex structural variations. accurately subtle among different populations further elucidate their associations traits, overcoming limitations providing more information research This review systematically summarizes latest applications analysis structures, diversity, economic adaptive while discussing faced by this technology. aims provide scientific foundation improvement conservation resources.

Язык: Английский

Процитировано

0
Genetic characterization of cashmere goat (Capra hircus) populations in Mongolia DOI Creative Commons

Sergelen Baldan,

Johann Sölkner, Kahsa Tadel Gebre

и другие.

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Сен. 17, 2024

Objective Characterization studies of the phenotypic and genetic diversity Mongolian goats are limited, despite several goat breeds being registered in country. This study aimed to evaluate 14 cashmere populations Mongolia, consisting largely identified breeds. Methods Body weight, quality, coat color were traits considered this study. A linear model was used fit body weight traits, least squares means ( LSMs ) estimated for region location classes. Genetic structure assessed using a 50K SNP array. Results The studied exhibited greater at regional level. very small overall differentiation index Fst : 0.017) revealed by Wright’s inbreeding F ROH1 :0.019) based on runs homozygosity. clustering principal components showed large variances two Russian admixture (Gobi Gurvan Saikhan Uuliin Bor), smaller but differentiated clusters remaining populations. Similar results observed analysis, which with highest (Govi Bor) lowest (Tsagaan Ovoo Khar) exotic admixtures. genomewide association (GWAS) few significant variants chromosomes 2, 4, 5, 9, 15, strongest variant yield chromosome 4. GWAS yielded nine variants, located 6, 13, 18 potential associations KIT , ASIP MC1R genes. These signals also found other patterns goats. Conclusion relatively low levels, possibly caused traditional pastoral livestock management system practice trading breeding bucks across provinces, along recent increase population. Further investigation larger samples alternative methods may help identify genes or genomic regions underlying quality

Язык: Английский

Процитировано

1
Screening and expression validation of key proteins for secondary hair follicle growth in cashmere goats based on iTRAQ quantitative proteomics technology DOI Creative Commons
Jiale Chang,

Meng Fan-hua,

Ru Zhang

и другие.

Frontiers in Veterinary Science, Год журнала: 2024, Номер 11

Опубликована: Окт. 15, 2024

Background The growth of secondary hair follicles (SHFs) in cashmere goats has periodic changes, including telogen, anagen, and catagen, during which proteins play important roles as the executor life activities. Results In this study, skin tissues at three different stages SHFs were collected for proteome sequencing validation experiments. Through protein differential expression analysis time series analysis, FKBP prolyl isomerase 10 (FKBP10) fibrillin 2 (FBN2) screened key SHF cycle goats, albumin (ALB), collagen type I alpha 1 chain (COL1A1) elastin (ELN) predicted to be their interacting proteins. results quantitative real-time PCR (qRT-PCR), western blot, immunohistochemistry experiments showed that mRNA levels FKBP10, FBN2, COL1A1, ELN ALB higher anagen lower telogen. They all highly expressed outer root sheath anagen. Conclusion ELN, can promote goats. This study lays foundation analyzing regulatory mechanism provides new ideas further improving yield quality.

Язык: Английский

Процитировано

1
Examination of homozygosity runs and selection signatures in native goat breeds of Henan, China DOI Creative Commons

Weifeng Peng,

Yiyuan Zhang, Lei Gao

и другие.

BMC Genomics, Год журнала: 2024, Номер 25(1)

Опубликована: Дек. 6, 2024

Язык: Английский

Процитировано

1
Genomic scans for selection and runs of homozygosity in southern Italian turkey populations DOI Creative Commons
Medhat S. Saleh, Vincenzo Landi, Martijn F. L. Derks

и другие.

Poultry Science, Год журнала: 2024, Номер 104(2), С. 104750 - 104750

Опубликована: Дек. 31, 2024

Язык: Английский

Процитировано

1
Genetic Diversity in the Orenburg Goat Breed Revealed by Single-Nucleotide Polymorphism (SNP) Analysis: Initial Steps in Saving a Threatened Population DOI Open Access
Т. Е. Денискова, А. В. Доцев, Alexandra S. Abdelmanova

и другие.

Genes, Год журнала: 2024, Номер 15(11), С. 1375 - 1375

Опубликована: Окт. 25, 2024

: Orenburg goats are renowned for their soft down that acts as a substrate warm clothing, particularly shawls have an international reputation. As with many local livestock breeds, however, the is presently at risk of extinction, issue can be addressed by assessing population genetic diversity and, thereafter, encouraging much outbreeding possible. Using single-nucleotide polymorphism (SNP)-based data, therefore, we analyzed and structure modern using samples collected from expedition to Oblast in 2024.

Язык: Английский

Процитировано

0
Development and Validation of a 5K Liquid Chip for Identifying Cashmere Goat Populations in Inner Mongolia Autonomous Region DOI Creative Commons
Tao Zhang,

Qi Xu,

Bohan Zhou

и другие.

Animals, Год журнала: 2024, Номер 14(24), С. 3589 - 3589

Опубликована: Дек. 12, 2024

(1) Background: Cashmere goats, as one of the characteristic species, are rich in genetic resources. Protecting and rationally utilizing these resources is great significance for improvement cashmere goats. (2) Methods: In this study, tissue samples were collected from Inner Mongolia white which included Arbas type (ARBS); Erlangshan (ELS); Alashan (ALS), Hanshan goats (HS), Ujimqin (WZMQ). Genomic DNA was extracted subjected to high-depth genome resequencing. GenoBait technology used probe design site optimization, followed by synthesis a low-density liquid phase chip. Finally, total 281 individuals five goat populations Autonomous Region randomly selected verify (3) Results: The results showed that 5002 SNP sites finally screened retained chip identifying Region. Principal component analysis phylogenetic tree construction indicated ARBS, ELS, ALS clustered into category. (4) Conclusions: This can accurately identify three breeds:

Язык: Английский

Процитировано

0
Genome-Wide Patterns of Homozygosity and Heterozygosity and Candidate Genes in Greek Insular and Mainland Native Goats DOI Open Access
Valentina Tsartsianidou,

Antonis Otapasidis,

Spiros Papakostas

и другие.

Genes, Год журнала: 2024, Номер 16(1), С. 27 - 27

Опубликована: Дек. 27, 2024

Runs of homozygosity (ROHs) and heterozygosity (ROHets) serve for the identification genomic regions as candidates selection, local adaptation, population history. The present study aimed to comprehensively explore ROH ROHet patterns hotspots in Greek native dairy goats, Eghoria Skopelos, genotyped with Illumina Goat SNP50 BeadChip. SNP functional enrichment analyses were conducted further characterize candidate genes located within these regions. Genetic relationships between breeds inbreeding coefficients also evaluated. Clear genetic differentiation diversified management practices depicted two populations. average genome coverage Skopelos (65.35 35 Mb) (47.64 43 indicated differences mainland insular showing more long fragments, reflecting its geographic isolation small size. An hotspot (CHR12: 43.59-44.61 detected has been reported across European goats co-localizes a selection signal Egyptian Barki sheep adapted hot-arid conditions. A novel (CHR18: 60.12-61.81 Mb), shared among breeds, harbors enriched biosynthesis, metabolism, immune response. Two well-conserved islands on chromosomes 1 18, participating development embryogenesis. showed highest number islands, potentially adaptability diverse environments. These findings offer new insights into environmental adaptation artificial could be utilized future breeding strategies sustainable goat farming.

Язык: Английский

Процитировано

0