Natural antioxidants that act against Alzheimer’s disease through modulation of the NRF2 pathway: a focus on their molecular mechanisms of action DOI Creative Commons

Grammatiki Alexandra Sidiropoulou,

Athanasios Metaxas, Malamati Kourti

и другие.

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Июль 3, 2023

Characterized by a complex pathophysiology that includes the intraneuronal formation of neurofibrillary tangles and extracellular deposition β-amyloid plaques, Alzheimer’s disease (AD) is terminal neurodegenerative causes dementia in older adults. Oxidative stress brain considered as one contributing factors to pathogenesis AD, thus, antioxidants have attracted much interest potential therapeutic agents against disorder. Natural are typically characterized low acute chronic toxicity, which facilitates their application. One important molecular target for beneficial effects natural nuclear factor erythroid-derived 2-related 2 (NFE2L2/NRF2). NRF2 key transcription orchestrates cellular antioxidant response through regulating expression oxidative stress-related genes harboring element (ARE) promoters. Indeed, case excessive damage, migrates nucleus binds ARE, activating protector genes. There increasing evidence implicated AD pathology dysfunction altered localization, renders it AD. Thus, this review summarizes most recent (2018-2023) advances on NRF2-modulating activity observed vitro animal models. This information will help elucidate mechanisms governing such phytochemicals highlight common diseases,

Язык: Английский

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration DOI Creative Commons
Sheryar Afzal, Aimi Syamima Abdul Manap, Ali Attiq

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Окт. 18, 2023

Increased production and buildup of reactive oxygen species (ROS) can lead to various health issues, including metabolic problems, cancers, neurological conditions. Our bodies counteract ROS with biological antioxidants such as SOD, CAT, GPx, which help prevent cellular damage. However, if there is an imbalance between these antioxidants, it result in oxidative stress. This cause genetic epigenetic changes at the molecular level. review delves into how plays a role disorders caused by We also look animal models used for researching pathways. study offers insights mechanism, pathology, changes, assist drug development disease understanding.

Язык: Английский

Процитировано

110
Molecular Mechanisms of Neuroinflammation in Aging and Alzheimer’s Disease Progression DOI Open Access
Felicia Liana Andronie-Cioară, Adriana Ioana Ardelean, Carmen Delia Nistor-Cseppento

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 1869 - 1869

Опубликована: Янв. 18, 2023

Aging is the most prominent risk factor for late-onset Alzheimer’s disease. associates with a chronic inflammatory state both in periphery and central nervous system, evidence thereof mechanisms leading to neuroinflammation being discussed. Nonetheless, significantly enhanced by accumulation of amyloid beta accelerates progression disease through various pathways discussed present review. Decades clinical trials targeting 2 abnormal proteins disease, tau, led many failures. As such, via different strategies could prove valuable therapeutic strategy, although much research still needed identify appropriate time window. Active focusing on identifying early biomarkers help translating these novel from bench bedside.

Язык: Английский

Процитировано

84
New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases DOI Open Access
Eveljn Scarian, Camilla Viola, Francesca Dragoni

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2698 - 2698

Опубликована: Фев. 26, 2024

Oxidative stress (OS) and inflammation are two important well-studied pathological hallmarks of neurodegenerative diseases (NDDs). Due to elevated oxygen consumption, the high presence easily oxidizable polyunsaturated fatty acids weak antioxidant defenses, brain is particularly vulnerable oxidative injury. Uncertainty exists over whether these deficits contribute development NDDs or solely a consequence neuronal degeneration. Furthermore, linked, it known that OS can affect inflammatory response. In this review, we will overview last findings about pathways in principal NDDs. Moreover, focus more depth on amyotrophic lateral sclerosis (ALS) understand how anti-inflammatory antioxidants drugs have been used for treatment still incurable motor neuron (MN) disease. Finally, analyze past actual clinical trials future perspectives study mechanisms.

Язык: Английский

Процитировано

45
Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications DOI Creative Commons

Umesh Chandra Dash,

Nitish Kumar Bhol,

Sandeep Kumar Swain

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 15(1), С. 15 - 34

Опубликована: Окт. 16, 2024

Neuroprotection is a proactive approach to safeguarding the nervous system, including brain, spinal cord, and peripheral nerves, by preventing or limiting damage nerve cells other components. It primarily defends central system against injury from acute progressive neurodegenerative disorders. Oxidative stress, an imbalance between body's natural defense mechanisms generation of reactive oxygen species, crucial in developing neurological Due its high metabolic rate consumption, brain particularly vulnerable oxidative stress. Excessive ROS damages essential biomolecules, leading cellular malfunction neurodegeneration. Several disorders, Alzheimer's, Parkinson's, Amyotrophic lateral sclerosis, multiple ischemic stroke, are associated with Understanding impact stress these conditions for new treatment methods. Researchers exploring using antioxidants molecules mitigate aiming prevent slow down progression diseases. By understanding intricate interplay scientists hope pave way innovative therapeutic preventive approaches, ultimately improving individuals' living standards.

Язык: Английский

Процитировано

43
Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer’s Disease DOI
Bidemi Emmanuel Ekundayo, Tajudeen Olabisi Obafemi, Olusola Bolaji Adewale

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(2), С. 457 - 477

Опубликована: Март 12, 2024

Язык: Английский

Процитировано

32
Quantum-mechanics-based structural analysis of phenolic glycosides from Cuscuta japonica seeds with protective effects against H2O2-induced oxidative stress in SH-SY5Y cells DOI

Hau Thi Hong Bui,

Ajay Uprety, Trung Huy Ngo

и другие.

Phytochemistry, Год журнала: 2025, Номер unknown, С. 114420 - 114420

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments DOI Open Access
Mateo Rodríguez-Giraldo, Rodrigo E. González-Reyes, Sofía Ramírez-Guerrero

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(21), С. 13630 - 13630

Опубликована: Ноя. 7, 2022

Alzheimer’s disease (AD) is a frequent and disabling neurodegenerative disorder, in which astrocytes participate several pathophysiological processes including neuroinflammation, excitotoxicity, oxidative stress lipid metabolism (along with critical role apolipoprotein E function). Current evidence shows that have both neuroprotective neurotoxic effects depending on the stage microenvironmental factors. Furthermore, appear to be affected by presence of amyloid-beta (Aβ), alterations calcium levels, gliotransmission proinflammatory activity via RAGE-NF-κB pathway. In addition, play an important tau clearance Aβ through glymphatic system. this review, we will discuss novel pharmacological non-pharmacological treatments focused as therapeutic targets for AD. These interventions include anti-inflammatory/antioxidant systems, glutamate activity, metabolism, neurovascular coupling system, dysregulation, release peptides affects glial neuronal function. According AD stage, these therapies may benefit either preventing or delaying progression disease.

Язык: Английский

Процитировано

64
The Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer’s Disease: Therapeutic Implications and Future Perspectives DOI Creative Commons
Maria Carolina Jurcău, Felicia Liana Andronie-Cioară, Anamaria Jurcău

и другие.

Antioxidants, Год журнала: 2022, Номер 11(11), С. 2167 - 2167

Опубликована: Окт. 31, 2022

Alzheimer’s disease (AD), the most common form of dementia, has increasing incidence, mortality rates, and poses a huge burden on healthcare. None currently approved drugs for treatment AD influence progression. Many clinical trials aiming at inhibiting amyloid plaque formation, beta clearance, or neurofibrillary tangle pathology yielded inconclusive results failed. Meanwhile, research identified many interlinked vicious cascades implicating oxidative stress, mitochondrial dysfunction, chronic neuroinflammation, pointed to novel therapeutic targets such as improving bioenergetics quality control, diminishing modulating neuroinflammatory pathways. molecules tested in vitro animal models have proven efficient, but their translation into clinic needs further regarding appropriate doses, delivery routes, possible side effects. Cell-based therapies extracellular vesicle-mediated messenger RNAs microRNAs seem also promising strategies allowing target specific signaling pathways, need harvesting culture methods well control tumorigenic The rapidly developing area nanotechnology could improve drug be used early diagnosis.

Язык: Английский

Процитировано

55
Exploring the Causal Relationship Between Telomere Biology and Alzheimer’s Disease DOI Creative Commons

Xi-Yuen Kuan,

Nurul Syahira Ahmad Fauzi,

Khuen Yen Ng

и другие.

Molecular Neurobiology, Год журнала: 2023, Номер 60(8), С. 4169 - 4183

Опубликована: Апрель 12, 2023

Telomeres, also known as the "protective caps" of our chromosomes, shorten with each cell cycle due to end replication problem. This process, termed telomere attrition, is associated many age-related disorders, such Alzheimer's disease (AD). Despite numerous studies conducted in this field, role attrition onset remains unclear. To investigate causal relationship between short telomeres and AD, review aims highlight primary factors that regulate length maintain its integrity, an additional outlook on oxidative stress, which commonly aging molecular damage. Although some findings thus far might be contradictory, likely plays a crucial progression AD close association stress. The currently available treatments for are only symptomatic without affecting disease. components biology discussed paper have previously been studied alternative treatment option several diseases exhibited promising vitro vivo results. Hence, should provide basis future research develop potential therapeutic strategy AD. (Created BioRender.com).

Язык: Английский

Процитировано

24
Alzheimer's disease: The role of proteins in formation, mechanisms, and new therapeutic approaches DOI

Amirreza Gholami

Neuroscience Letters, Год журнала: 2023, Номер 817, С. 137532 - 137532

Опубликована: Окт. 20, 2023

Язык: Английский

Процитировано

22