Acta Neuropathologica, Год журнала: 2025, Номер 149(1)
Опубликована: Апрель 4, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9605 - 9605
Опубликована: Май 31, 2023
S100B is a calcium-binding protein mainly concentrated in astrocytes the nervous system. Its levels biological fluids are recognized as reliable biomarker of active neural distress, and more recently, mounting evidence points to Damage-Associated Molecular Pattern molecule, which, at high concentration, triggers tissue reactions damage. and/or distribution patients experimental models different disorders, for which used biomarker, directly related progress disease. In addition, diseases such Alzheimer’s Parkinson’s diseases, amyotrophic lateral sclerosis, multiple traumatic vascular acute injury, epilepsy, inflammatory bowel disease, alteration correlates with occurrence clinical toxic parameters. general, overexpression/administration worsens presentation, whereas deletion/inactivation contributes amelioration symptoms. Thus, may be proposed common pathogenic factor sharing symptoms etiologies but appearing share some processes reasonably attributable neuroinflammation.
Язык: Английский
Процитировано
50
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14499 - 14499
Опубликована: Сен. 24, 2023
Over the past 30 years, majority of (pre)clinical efforts to find an effective therapy for Alzheimer’s disease (AD) focused on clearing β-amyloid peptide (Aβ) from brain since, according amyloid cascade hypothesis, was (and it is still considered by many) pathogenic determinant this neurodegenerative disorder. However, as reviewed in article, results numerous clinical trials that have tested anti-Aβ therapies date indicate plays a minor role pathogenesis AD. Indeed, even Aducanumab and Lecanemab, two antibodies recently approved FDA AD therapy, well Donanemab showed limited efficacy cognitive parameters phase III trials, despite their capability markedly lowering Aβ load. Furthermore, preclinical evidence demonstrates possesses several physiological functions, including memory formation, suggesting may part be due loss function peptide. Finally, generally accepted could result many molecular dysfunctions, therefore, if we keep chasing only Aβ, means cannot see forest trees.
Язык: Английский
Процитировано
32
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(36), С. 8605 - 8621
Опубликована: Янв. 1, 2023
Alzheimer's disease (AD) is a neurodegenerative that causes memory and cognitive dysfunction reduces person's decision-making reasoning functions. AD the leading cause of dementia in elderly. Patients with have increased expression pro-inflammatory cytokines nervous system, sustained inflammatory response impairs neuronal function. Meanwhile, long-term use anti-inflammatory drugs can reduce incidence to some extent. This confirms anti-neuroinflammation may be an effective treatment for AD. Gold nanoparticles (AuNPs) are emerging nanomaterial promising physicochemical properties, antioxidant. AuNPs neuroinflammation by inducing macrophage polarization toward M2 phenotype, reducing cytokine expression, blocking leukocyte adhesion, decreasing oxidative stress. Therefore, gradually attracting interest scholars used treating diseases drug delivery. Herein, we explored role mechanism The topic worth exploring future, not only help solve global public health problem but also provide reference other neuroinflammatory diseases.
Язык: Английский
Процитировано
26
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 11955 - 11955
Опубликована: Ноя. 7, 2024
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two prevalent conditions that present considerable public health issue in aging populations worldwide. Recent research has proposed a novel conceptualization of AD as "type 3 diabetes", highlighting the critical roles insulin resistance impaired glucose metabolism pathogenesis disease. This article examines implications this association, exploring potential new avenues for treatment preventive strategies AD. Key evidence linking to emphasizes metabolic processes contribute neurodegeneration, including inflammation, oxidative stress, alterations signaling pathways. By framing within context, we can enhance our understanding its etiology, which turn may influence early diagnosis, plans, measures. Understanding manifestation opens up possibility employing therapeutic incorporate lifestyle modifications use antidiabetic medications mitigate cognitive decline. integrated approach improve patient outcomes deepen comprehension intricate relationship between neurodegenerative diseases disorders.
Язык: Английский
Процитировано
11
Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Background Alzheimer's disease (AD), the leading cause of dementia, is characterized by cognitive decline and accumulation amyloid-β (Aβ). It affects millions, with numbers expected to double 2050. SMOC2, implicated in inflammation fibrosis, may play a role AD pathogenesis, particularly microglial cell function, offering potential therapeutic target. Objective (AD) leads neurodegeneration, affecting cognition, language, personality, underscoring urgency for effective treatments. Our study investigates secreted modular calcium-binding protein 2 (SMOC2) cells its impact on pathology. Methods We introduced SMOC2 overexpression interference vectors into treated Aβ. Activity phagocytosis were assessed using CCK8 flow cytometry. mRNA levels quantified qPCR, TGF-β1, p-NF-κB/NF-κB analyzed western blot. Aβ content was determined ELISA, immunofluorescence detected TNF-α, IL-1β, CD163, CD206. Results treatment inhibited activity phagocytosis, but disruption enhanced these functions (p < 0.05). increased expression levels, while reduced them 0.001). also decreased CD206, p-NF-κB/NF-κB, IL-1β Conclusions plays crucial activity, polarization, potentially through TGF-β1/NF-κB pathway, insights pathogenesis.
Язык: Английский
Процитировано
1
Cells, Год журнала: 2024, Номер 13(2), С. 148 - 148
Опубликована: Янв. 12, 2024
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced therapeutic interventions. This detailed review explores the critical roles of astrocytes, key cellular constituents central nervous system (CNS), in both pathophysiology and possible rehabilitation TBI. Following injury, astrocytes exhibit reactive transformations, differentiating into pro-inflammatory (A1) neuroprotective (A2) phenotypes. paper elucidates interactions with neurons, their role neuroinflammation, potential for exploitation. Emphasized strategies encompass utilization endocannabinoid calcium signaling pathways, hormone-based treatments like 17β-estradiol, biological therapies employing anti-HBGB1 monoclonal antibodies, gene therapy targeting Connexin 43, innovative technique astrocyte transplantation as means to repair damaged neural tissues.
Язык: Английский
Процитировано
7
RSC Chemical Biology, Год журнала: 2022, Номер 4(2), С. 121 - 131
Опубликована: Ноя. 22, 2022
This review describes the effects of metal ions on aggregation and toxicity profiles Aβ.
Язык: Английский
Процитировано
23
Cells, Год журнала: 2023, Номер 12(18), С. 2318 - 2318
Опубликована: Сен. 20, 2023
Neurodegenerative diseases (NDDs) like Alzheimer’s disease (AD), Parkinson’s (PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex aetiologies. Understanding the common biochemical molecular pathologies among NDDs gives an opportunity to decipher overlapping numerous cross-talk mechanisms neurodegeneration. Numerous interrelated pathways lead progression We present evidence from past pieces literature for most usual global convergent hallmarks ageing, oxidative stress, excitotoxicity-induced calcium butterfly effect, defective proteostasis including chaperones, autophagy, mitophagy, proteosome networks, neuroinflammation. Herein, we applied holistic approach identify represent shared mechanism across NDDs. Further, believe that this could be helpful in identifying key modulators NDDs, with particular focus on AD, PD, ALS. Moreover, these concepts development diagnosis novel strategies diverse
Язык: Английский
Процитировано
15
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 29, 2024
The crosstalk between astrocytes and microglia plays a pivotal role in neuroinflammation following ischemic stroke, phenotypic distribution of these cells can change with the progression stroke. Peroxiredoxin (PRDX) 6 phospholipase A2 (iPLA2) activity is involved generation reactive oxygen species(ROS), ROS driving activation astrocytes; however, its exact function remains unexplored. MJ33, PRDX6
Язык: Английский
Процитировано
5
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(11), С. 3098 - 3098
Опубликована: Май 25, 2024
Alzheimer's disease (AD) causes a significant challenge to global healthcare systems, with limited effective treatments available. This review examines the landscape of novel therapeutic strategies for AD, focusing on shortcomings traditional therapies against amyloid-beta (Aβ) and exploring emerging alternatives. Despite decades research emphasizing role Aβ accumulation in AD pathogenesis, clinical trials targeting have obtained disappointing results, highlighting complexity pathophysiology need investigating other approaches. In this manuscript, we first discuss challenges associated anti-Aβ therapies, including efficacy potential adverse effects, underscoring necessity alternative mechanisms targets. Thereafter, promising non-Aβ-based strategies, such as tau-targeted neuroinflammation modulation, gene stem cell therapy. These approaches offer new avenues treatment by addressing additional pathological hallmarks downstream effects beyond deposition.
Язык: Английский
Процитировано
5