Neuroscience Letters, Год журнала: 2022, Номер 793, С. 136997 - 136997
Опубликована: Дек. 2, 2022
Язык: Английский
Ageing Research Reviews, Год журнала: 2023, Номер 90, С. 102032 - 102032
Опубликована: Авг. 10, 2023
Язык: Английский
Процитировано
56
Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102323 - 102323
Опубликована: Май 9, 2024
Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.
Язык: Английский
Процитировано
24
Trends in Neurosciences, Год журнала: 2022, Номер 45(9), С. 692 - 703
Опубликована: Июль 23, 2022
Язык: Английский
Процитировано
41
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14582 - 14582
Опубликована: Сен. 26, 2023
Parkinson’s disease is a neurodegenerative exhibiting the fastest growth in incidence recent years. As with most diseases, pathophysiology incompletely elucidated, but compelling evidence implicates inflammation, both central nervous system and periphery, initiation progression of disease, although it not yet clear what triggers this inflammatory response where begins. Gut dysbiosis seems to be likely candidate for systemic inflammation. The therapies current use provide only symptomatic relief, do interfere progression. Nonetheless, animal models have shown promising results that target various vicious neuroinflammatory cascades. Translating these therapeutic strategies into clinical trials still its infancy, series issues, such as exact timing, identifying biomarkers able identify early pre-symptomatic stages, or proper indications genetic testing population at large, will need settled future guidelines.
Язык: Английский
Процитировано
22
Antioxidants, Год журнала: 2024, Номер 13(10), С. 1228 - 1228
Опубликована: Окт. 12, 2024
Alpha-lipoic acid (ALA) is a bioactive molecule with significant health effects. The biological action of ALA has been ascribed to the characteristic antioxidant properties oxidized form and its reduced counterpart dihydrolipoic (DHLA) system. ALA/DHLA combination represents an ideal since it can quench radicals, able chelate metals, amphiphilic, no major adverse This unique system scavenge reactive oxygen species, exerting effect on tissue levels forms other antioxidants, including glutathione. For this reason, also known as "antioxidant antioxidants". review analyzes antioxidant, anti-inflammatory, neuroprotective effects discusses applications ameliorative tool for chronic diseases those associated oxidative stress. Results from in vitro vivo studies demonstrated that modulates various stress pathways suggesting application, alone or functional substances, useful support numerous conditions, which balance oxidant-antioxidant disrupted, such neurodegenerative disorders. Based several successful clinical studies, established oral supplements are clinically relieving complications diabetes disorders cardiovascular nerve discomforts be considered approach improving our health.
Язык: Английский
Процитировано
9
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(23), С. 15218 - 15218
Опубликована: Дек. 2, 2022
Neurodegenerative disorders are characterized by the progressive loss of central and/or peripheral nervous system neurons. Within this context, neuroinflammation comes up as one main factors linked to neurodegeneration progression. In fact, has been recognized an outstanding factor for Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s (PD), and multiple (MS). Interestingly, neuroinflammatory diseases dramatic changes in epigenetic profile, which might provide novel prognostic therapeutic towards treatment. Deep DNA histone methylation, along with acetylation altered non-coding RNA expression, have reported at onset inflammatory diseases. The aim work is review current knowledge on field.
Язык: Английский
Процитировано
33
Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15
Опубликована: Сен. 5, 2023
Parkinson's disease (PD) is the second-most common neurodegenerative and largely caused by death of dopaminergic (DA) cells. Dopamine loss occurs in substantia nigra pars compacta leads to dysfunctions motor functions. Death DA cells can occur with oxidative stress dysfunction glial Parkinson-related gene mutations. Lactoferrin (Lf) a multifunctional glycoprotein that usually known for its presence milk, but recent research shows Lf also found brain regions. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mitochondrial toxin disturbs electron transport chain (ETC) system increases rate reactive oxygen species. Lf's high affinity metals decreases required iron Fenton reaction, reduces damage MPTP, their surveillance rate. Several studies investigated effect on neurons are treated MPTP. The results pointed out protective be observed without stress; thus, several potential mechanisms currently being researched, starting HSPG–Lf interaction cellular membrane activity region showed lactoferrin initiates receptor-mediated transcytosis blood–brain barrier (BBB) existence receptors endothelial both created idea using as secondary molecule therapeutic agents across BBB, especially nanoparticle development.
Язык: Английский
Процитировано
22
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2950 - 2950
Опубликована: Фев. 2, 2023
Glutathione (GSH) is necessary for maintaining physiological antioxidant function, which responsible free radicals derived from reactive oxygen species at low levels and associated with improved cognitive performance after brain injury. GSH produced by the linkage of tripeptides that consist glutamic acid, cysteine, glycine. The adequate supplementation has neuroprotective effects in several injuries such as cerebral ischemia, hypoglycemia, traumatic Brain produce an excess through complex biochemical cascades, exacerbates primary neuronal damage. concentrations are known to be closely correlated activities certain genes excitatory amino acid carrier 1 (EAAC1), glutamate transporter-associated protein 3–18 (Gtrap3-18), zinc transporter 3 (ZnT3). Following brain-injury-induced oxidative stress, EAAC1 function negatively impacted, then reduces cysteine absorption impairs synthesis. In these circumstances, vesicular also released into synaptic cleft translocated postsynaptic neurons. excessive influx inhibits glutathione reductase, GSH’s functions neurons, resulting damage ultimately impairment function. Therefore, this review, we explore overall relationship between terms stress cell death. Furthermore, seek understand how modulation can rescue brain-insult-induced death
Язык: Английский
Процитировано
16
Antioxidants, Год журнала: 2024, Номер 13(2), С. 169 - 169
Опубликована: Янв. 29, 2024
Taurine is ubiquitously distributed in mammalian tissues, with the highest levels brain, heart, and leukocytes. reacts hypochlorous acid (HOCl) to produce taurine chloramine (Tau-Cl) via myeloperoxidase (MPO) system. In this study, we elucidated antioxidative protective effects of Tau-Cl astrocytes. increased expression nuclear translocation factor E2-related (Nrf2) Nrf2-regulated antioxidant genes, including heme oxygenase 1 (HO-1). Nrf2 activity negatively regulated by Kelch-like ECH-associated protein (Keap1). decreased level reduced thiol groups Keap1, resulting disruption Keap1-Nrf2 complex. Consequently, rescued H2O2-induced cell death enhancing HO-1 suppressing reactive oxygen species. conclusion, confers astrocytes disrupting complex, thereby promoting nucleus, wherein it binds response element (ARE) accelerates transcription genes. Therefore, astrocytes, activation Keap1-Nrf2-ARE pathway may increase antioxidants anti-inflammatory mediators as well other cytoprotective proteins, conferring protection against brain infection injury.
Язык: Английский
Процитировано
5
Biochemical Society Transactions, Год журнала: 2024, Номер 52(3), С. 1275 - 1291
Опубликована: Май 30, 2024
Parkinsonism is the primary type of movement disorder in adults, encompassing a set clinical symptoms, including rigidity, tremors, dystonia, bradykinesia, and postural instability. These symptoms are primarily caused by deficiency dopamine (DA), an essential neurotransmitter brain. Currently, DA precursor levodopa (synthetic L-DOPA) standard medication to treat deficiency, but it only addresses rather than provides cure. In this review, we provide overview disorders associated with dysregulation particularly Parkinson's disease rare inherited leading predominantly dystonia and/or parkinsonism, even childhood. Although relatively effective for management motor dysfunctions, less severe forms parkinsonism also side effects loss efficacy over time. We present ongoing efforts reinforce effect develop innovative therapies that target underlying pathogenic mechanisms affecting synthesis transport, increasing neurotransmission through disease-modifying approaches, such as cell-based therapies, nucleic acid- protein-based biologics, small molecules.
Язык: Английский
Процитировано
5