A sex-specific anti-inflammatory role for p62 in psoriasis-like disease DOI

K. Mieczkowski,

Latifa Bakiri, Johannes Griss

и другие.

Journal of Investigative Dermatology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Intradermal delivery of teriflunomide loaded emulsomes using hollow microneedles for effective minimally invasive psoriasis management DOI
Mariam Zewail,

Haidy Abbas,

Nesrine S. El Sayed

и другие.

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2025, Номер 210, С. 114692 - 114692

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

0
Liposomes-in-Gel as the Docetaxel Delivery for the Effective Treatment of Psoriasis by Inhibiting the Proliferation of Blood Vessels DOI Creative Commons

Ruoyang Jia,

Yinyin Liu,

Yi‐Fang Wu

и другие.

Gels, Год журнала: 2025, Номер 11(4), С. 228 - 228

Опубликована: Март 22, 2025

Psoriasis is a chronic skin disease caused by the interaction of multiple factors that leads to abnormal growth stratum corneum cells and has been called an immortal cancer. Docetaxel trialed for treatment psoriasis due its superior ability induce apoptosis, but insolubility low bioavailability have hampered development. Here, docetaxel (DTX)-loaded liposomes-in-gel (DTX-LP-G) as transdermal delivery was investigated via modulating IL6-HIF-1α-VEGF axis. The results demonstrated DTX-LP-G cumulatively released much higher amount drug into than from DTX-loaded liposomes (DTX-LPs) gel (DTX-G). also most efficient in scavenging hydrogen peroxide free radicals vitro. In mouse model psoriasis, acted preliminary therapeutic agent terms apparent evaluation, splenomegaly, suppression MDA content tissue, down-regulated expression IL6, HIF-1α, VEGF control proliferation vessels, except less pronounced effect on corneum. addition, enrichment analysis can speculate DTX treated resisting production keratin-forming cells.

Язык: Английский

Процитировано

0
Low-density lipoprotein receptor-related protein-1 and nitrative stress in psoriasis vulgaris: a cross-sectional study DOI
Işıl Yağmur, Ergül Belge Kurutaş, Perihan Öztürk

и другие.

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Апрель 11, 2025

Язык: Английский

Процитировано

0
Oxidative stress and free radicals in disease pathogenesis: a review DOI Creative Commons

G. Hitha Pooja,

Singh Shweta, Pragna Patel

и другие.

Deleted Journal, Год журнала: 2025, Номер 2(1)

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0
A sex-specific anti-inflammatory role for p62 in psoriasis-like disease DOI

K. Mieczkowski,

Latifa Bakiri, Johannes Griss

и другие.

Journal of Investigative Dermatology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0