A sex-specific anti-inflammatory role for p62 in psoriasis-like disease DOI

K. Mieczkowski,

Latifa Bakiri, Johannes Griss

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Intradermal delivery of teriflunomide loaded emulsomes using hollow microneedles for effective minimally invasive psoriasis management DOI
Mariam Zewail,

Haidy Abbas,

Nesrine S. El Sayed

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2025, Volume and Issue: 210, P. 114692 - 114692

Published: March 11, 2025

Language: Английский

Citations

0
Liposomes-in-Gel as the Docetaxel Delivery for the Effective Treatment of Psoriasis by Inhibiting the Proliferation of Blood Vessels DOI Creative Commons

Ruoyang Jia,

Yinyin Liu,

Yi‐Fang Wu

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 228 - 228

Published: March 22, 2025

Psoriasis is a chronic skin disease caused by the interaction of multiple factors that leads to abnormal growth stratum corneum cells and has been called an immortal cancer. Docetaxel trialed for treatment psoriasis due its superior ability induce apoptosis, but insolubility low bioavailability have hampered development. Here, docetaxel (DTX)-loaded liposomes-in-gel (DTX-LP-G) as transdermal delivery was investigated via modulating IL6-HIF-1α-VEGF axis. The results demonstrated DTX-LP-G cumulatively released much higher amount drug into than from DTX-loaded liposomes (DTX-LPs) gel (DTX-G). also most efficient in scavenging hydrogen peroxide free radicals vitro. In mouse model psoriasis, acted preliminary therapeutic agent terms apparent evaluation, splenomegaly, suppression MDA content tissue, down-regulated expression IL6, HIF-1α, VEGF control proliferation vessels, except less pronounced effect on corneum. addition, enrichment analysis can speculate DTX treated resisting production keratin-forming cells.

Language: Английский

Citations

0
Low-density lipoprotein receptor-related protein-1 and nitrative stress in psoriasis vulgaris: a cross-sectional study DOI
Işıl Yağmur, Ergül Belge Kurutaş, Perihan Öztürk

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: April 11, 2025

Language: Английский

Citations

0
Oxidative stress and free radicals in disease pathogenesis: a review DOI Creative Commons

G. Hitha Pooja,

Singh Shweta, Pragna Patel

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: April 14, 2025

Language: Английский

Citations

0
A sex-specific anti-inflammatory role for p62 in psoriasis-like disease DOI

K. Mieczkowski,

Latifa Bakiri, Johannes Griss

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0