Oxidative Stress and Male Infertility: The Protective Role of Antioxidants

Medicina, Год журнала: 2023, Номер 59(10), С. 1769 - 1769

Опубликована: Окт. 4, 2023

Oxidative stress is a significant factor in male infertility, compromising sperm function and overall reproductive health. As infertility garners increasing attention, effective therapeutic interventions become paramount. This review investigates the role of antioxidants addressing infertility. A detailed examination was conducted on such as vitamin C, E, B12, D, coenzyme Q10, zinc, folic acid, selenium, l-carnitine, l-arginine, inositols, alpha-lipoic acid. analysis examines methodologies, outcomes, constraints current clinical studies. Antioxidants show notable potential counteracting negative effects oxidative sperm. Based evidence, these antioxidants, individually or synergistically, can enhance health outcomes. However, certain limitations studies call for careful interpretation. are integral tackling attributed to stress. The findings underscore their value, yet there’s pressing need deeper, comprehensive research. Future should focus refining dosage guidelines, identifying side effects, discerning most efficacious antioxidant combinations solutions.

Язык: Английский

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The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Июль 27, 2023

Male reproductive function is highly susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. Oxidative stress can significantly impair sperm quality, including count, motility, morphology, DNA integrity, leading male infertility. Antioxidants play a crucial role in maintaining health by neutralizing ROS protecting cells damage. This review article explores the impact of on investigates potential benefits supplementation mitigating its detrimental effects. A comprehensive literature search was conducted gather relevant studies examining effects fertility outcomes supplementation. The findings reveal that improve some individuals. However, conflicting research limitations study design highlight need for further investigation. Factors such as individual variations, underlying causes infertility, dosage, duration should be carefully considered. Lifestyle modifications, healthy diet exercise, are reducing optimizing health. provides valuable insights into complex relationship function, emphasizing supportive strategy. Further warranted establish optimal protocols, identify specific subgroups may benefit most, explore advancements therapies outcomes.

Язык: Английский

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Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(2), С. 198 - 198

Опубликована: Фев. 11, 2024

Semen quality represents a compelling factor for fertility, and delineating the normal values has proven difficult. In last four decades, several authors have reported noticeable decline in sperm parameters. Also, studies investigating ‘time to pregnancy’ shown that fecundity begins be reduced when numbers decrease below 30 million, even though according 6th edition of WHO manual, value is currently 16 million/mL or 39 million per ejaculate. There exists sufficient data suggest counts over time, clear reason this adverse trend not well established, but some associations been hypothesised, such as maternal smoking during pregnancy. Additional potential factors yet fully illustrated involve poor diet, increased obesity, exposure environmental toxins. Moreover, change conditions more common endocrine-disrupting chemicals (EDCs), pesticides herbicides, bisphenol A, phthalates, polychlorinated biphenyls, heavy metals, starting from prenatal life continuing into adulthood, may exhibit probable features explaining reduction Therefore, main goal narrative review furnish an overview possible effects EDCs on testicular function spermatogenesis and, also, summarise evidence regarding examine its consequences.

Язык: Английский

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Pinostrobin alleviates testicular and spermatological damage induced by polystyrene microplastics in adult albino rats

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114686 - 114686

Опубликована: Апрель 10, 2023

Polystyrene microplastics (PS-MPs) have become major environmental pollutants that adversely effects multiple organs specifically testicles. Pinostrobin (PN) is an important flavonoid which, shows several pharmacological potentials.

Язык: Английский

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Male reproductive ageing: a radical road to ruin

Human Reproduction, Год журнала: 2023, Номер 38(10), С. 1861 - 1871

Опубликована: Авг. 10, 2023

In modern post-transition societies, we are reproducing later and living longer. While the impact of age on female reproductive function has been well studied, much less is known about intersection male reproduction. Our current understanding that advancing brings forth a progressive decline in fertility accompanied by reduction circulating testosterone levels appearance age-dependent pathologies including benign prostatic hypertrophy erectile dysfunction. Paternal ageing also associated with profound increase sperm DNA damage, multiple epigenetic changes germ line an elevated mutational load offspring. The net result such disease burden carried progeny males, dominant genetic diseases as Apert syndrome achondroplasia, neuropsychiatric conditions autism spontaneous schizophrenia. basis these age-related effects appears to involve two fundamental mechanisms. first positive selection mechanism whereby stem cells containing mutations mitogen-activated protein kinase pathway gain selective advantage over their non-mutant counterparts exhibit significant clonal expansion passage time. second dependent oxidative stress which impairs steroidogenic capacity Leydig cells, disrupts ability Sertoli support normal differentiation functional integrity spermatozoa. Given central importance defining chronological reproduction, there may be role for antioxidants clinical management this process. animal studies supportive strategy, carefully designed trials now needed if realize therapeutic potential approach context.

Язык: Английский

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DNA damage in testicular germ cells and spermatozoa. When and how is it induced? How should we measure it? What does it mean?

Andrology, Год журнала: 2023, Номер 11(8), С. 1545 - 1557

Опубликована: Янв. 6, 2023

This review surveys the causes and consequences of DNA damage in male germ line from spermatogonial stem cells to fully differentiated spermatozoa. Within cell population, integrity is well maintained as a result excellent surveillance repair; however, progressive increase background mutation rates does occur with paternal age possibly aberrant repair replication error. Once has committed spermatogenesis, it responds genetic via range pathways or, if this process fails, by induction apoptosis. When fully-differentiated spermatozoa are stressed, they also activate truncated intrinsic apoptotic pathway which results activation nucleases mitochondria cytoplasm; physical architecture these prevents enzymes translocating nucleus induce fragmentation. Conversely, hydrogen peroxide released sperm midpiece during apoptosis able penetrate damage. The base excision such cleaving oxidized bases DNA, leaving abasic sites that alkali-labile readily detected comet assay. As levels oxidative stress enter perimortem, topoisomerase integrated into chromatin becomes activated SUMOylation. Such may initially facilitate reannealing double strand breaks but ultimately prepares for destruction reproductive tract. lesions found live mutagenic mutational load carried offspring, particularly context assisted conception. A variety strategies described managing patients expressing high their spermatozoa, reduce risks might pose offspring health.

Язык: Английский

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Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches

Medicina, Год журнала: 2024, Номер 60(6), С. 1008 - 1008

Опубликована: Июнь 20, 2024

Infertility is a prevalent global issue affecting approximately 17.5% of adults, with sole male factor contributing to 20–30% cases. Oxidative stress (OS) critical in infertility, disrupting the balance between reactive oxygen species (ROS) and antioxidants. This imbalance detrimentally affects sperm function viability, ultimately impairing fertility. OS also triggers molecular changes sperm, including DNA damage, lipid peroxidation, alterations protein expression, further compromising functionality potential fertilization. Diagnostic tools discussed this review offer insights into markers, antioxidant levels, intracellular ROS concentrations. By accurately assessing these parameters, clinicians can diagnose infertility more effectively thus tailor treatment plans individual patients. Additionally, explores various options for males OS-associated such as empirical drugs, antioxidants, nanoantioxidants, lifestyle modifications. addressing root causes implementing targeted interventions, optimize outcomes enhance chances conception couples struggling infertility.

Язык: Английский

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Embryo development is impaired by sperm mitochondrial-derived ROS

Biological Research, Год журнала: 2024, Номер 57(1)

Опубликована: Янв. 30, 2024

Abstract Background Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While molecular pathways underlying these events still need be elucidated, reactive oxygen species (ROS) could have a relevant role. We, therefore, aimed describe mechanisms through which mitochondrial activity can influence first stages of Results We show that development tightly influenced by both intracellular ROS and activity. In addition, we depict inhibition dramatically decreases levels. Finally, demonstrate respiration positively influences sperm DNA integrity, most likely because depletion formation. Conclusion Collectively, data presented this work reveals impairment early may result from accumulation damage caused mitochondrial-derived ROS.

Язык: Английский

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Glyphosate presence in human sperm: First report and positive correlation with oxidative stress in an infertile French population

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 278, С. 116410 - 116410

Опубликована: Май 1, 2024

Environmental exposure to endocrine disruptors, such as pesticides, could contribute a decline of human fertility. Glyphosate (GLY) is the main component Based Herbicides (GBHs), which are most commonly herbicides used in world. Various animal model studies demonstrated its reprotoxicity. In Europe, GLY authorization agriculture has been extended until 2034. Meanwhile toxicity humans still debate. The aims our study were firstly analyse concentration and metabolite, amino-methyl-phosphonic acid (AMPA) by LC/MS-MS seminal blood plasma an infertile French men population (n=128). We secondly determined Total Antioxidant Status (TAS) Oxidant (TOS) using commercial colorimetric kits some oxidative stress biomarkers including malondialdehyde (MDA) 8-hydroxy-2′-deoxyguanosine (8-OHdG) ELISA assays. next analysed potential correlations between sperm parameters (sperm concentration, progressive speed, anormal forms). Here, we detected for first time significant proportions showed that was four times higher than those observed plasma. At opposite, AMPA undetectable. also strong positive correlation concentrations 8-OHdG concentrations, latter reflecting DNA impact. addition, TOS, Oxidative Stress Index (OSI) (TOS/TAS), MDA significantly with glyphosate plasma, respectively. Taken together, results suggest negative impact on reproductive health possibly his progeny. A precaution principle should be applied at actual discussion GBHs formulants uses Europe authorities.

Язык: Английский

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Decoding the Puzzle of Male Infertility: The Role of Infection, Inflammation, and Autoimmunity

Diagnostics, Год журнала: 2025, Номер 15(5), С. 547 - 547

Опубликована: Фев. 24, 2025

Background/Objectives: Male infertility is a complex, multifactorial condition influenced by infectious, inflammatory, and autoimmune components. Immunological factors, though implicated in reproduction, remain poorly understood. This study aims to deepen the understanding of infections, inflammation, factors male infertility, with focus on immune-related disorders affecting testes epididymis-immunologically privileged but vulnerable sites. These can impair sperm quality through oxidative stress (ROS) antisperm antibodies (ASA), further compromising fertility. Methods: A narrative review was conducted analyzing scientific literature from past 10 years PubMed using keywords such as "male infertility", "autoimmunity", "inflammatory disease". Studies focusing testicular epididymal disorders, immunological impacts, therapeutic approaches were included. Results: Our research highlights that conditions like epididymitis, vasectomy, trauma, previous surgeries trigger inflammatory responses, leading ASA formation stress. ASA, particularly sperm-immobilizing antibodies, inhibits motility migration female reproductive tract. Infections caused sexually transmitted bacteria or urinary pathogens frequently induce epididymo-orchitis, primary contributor infertility. While standardized methodologies for testing elusive, assisted treatments intracytoplasmic injection (ICSI), vitro fertilization (IVF), intrauterine insemination (IUI) show promise overcoming immune-mediated Conclusions: underscores critical role infection, responses It necessity improving diagnostic methods, immune-pathological mechanisms, addressing medicolegal issues associated knowledge could pave way innovative therapies, ultimately enhancing fertility outcomes, mitigating societal legal repercussions

Язык: Английский

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