Antioxidants,
Год журнала:
2023,
Номер
12(3), С. 546 - 546
Опубликована: Фев. 21, 2023
Mounting
evidence
indicates
that
the
microbiota,
unique
combination
of
micro-organisms
residing
in
a
specific
environment,
plays
an
essential
role
development
wide
range
human
diseases,
including
skin
cancer.
Moreover,
persistent
imbalance
microbial
community,
named
dysbiosis,
can
also
be
associated
with
oxidative
stress,
well-known
emerging
force
involved
pathogenesis
several
cutaneous
malignancies.
Although
their
interplay
has
been
somewhat
suggested,
connection
between
and
cancer
is
largely
unexplored
field.
In
present
review,
we
discuss
current
knowledge
on
these
topics,
suggesting
potential
therapeutic
strategies.
Antioxidants,
Год журнала:
2022,
Номер
11(12), С. 2345 - 2345
Опубликована: Ноя. 27, 2022
Organisms
are
continually
exposed
to
exogenous
and
endogenous
sources
of
reactive
oxygen
species
(ROS)
other
oxidants
that
have
both
beneficial
deleterious
effects
on
the
cell.
ROS
important
roles
in
a
wide
range
physiological
processes;
however,
high
levels
associated
with
oxidative
stress
disease
progression.
Oxidative
has
been
implicated
nearly
all
major
human
diseases,
from
neurogenerative
diseases
neuropsychiatric
disorders
cardiovascular
disease,
diabetes,
cancer.
Antioxidant
defence
systems
evolved
as
means
protection
against
stress,
transcription
factor
Nrf2
key
regulator.
is
responsible
for
regulating
an
extensive
panel
antioxidant
enzymes
involved
detoxification
elimination
extensively
studied
contexts.
This
review
aims
provide
reader
general
overview
Nrf2,
including
basic
mechanisms
activation
regulation,
implications
various
diseases.
Antioxidants,
Год журнала:
2022,
Номер
11(6), С. 1128 - 1128
Опубликована: Июнь 8, 2022
Cancer
is
characterized
by
increased
oxidative
stress,
an
imbalance
between
reactive
oxygen
species
(ROS)
and
antioxidants.
Enhanced
ROS
accumulation,
as
a
result
of
metabolic
disturbances
signaling
aberrations,
can
promote
carcinogenesis
malignant
progression
inducing
gene
mutations
activating
pro-oncogenic
signaling,
providing
possible
rationale
for
targeting
stress
in
cancer
treatment.
While
numerous
antioxidants
have
demonstrated
therapeutic
potential,
their
clinical
efficacy
remains
unproven.
Here,
we
review
the
for,
recent
advances
in,
pre-clinical
research
on
antioxidant
therapy
cancer,
including
with
nonenzymatic
antioxidants,
such
NRF2
activators,
vitamins,
N-acetylcysteine
GSH
esters,
or
enzymatic
NOX
inhibitors
SOD
mimics.
In
addition,
will
offer
insights
into
prospective
options
improving
effectiveness
therapy,
which
may
expand
its
applications
Cells,
Год журнала:
2023,
Номер
12(11), С. 1545 - 1545
Опубликована: Июнь 4, 2023
Placentation
is
a
key
and
tightly
regulated
process
that
ensures
the
normal
development
of
placenta
fetal
growth.
Preeclampsia
(PE)
hypertensive
pregnancy-related
disorder
involving
about
5–8%
all
pregnancies
clinically
characterized
by
de
novo
maternal
hypertension
proteinuria.
In
addition,
PE
are
also
increased
oxidative
stress
inflammation.
The
NRF2/KEAP1
signaling
pathway
plays
an
important
role
in
protecting
cells
against
damage
due
to
reactive
oxygen
species
(ROS)
levels.
ROS
activate
NRF2,
allowing
its
binding
antioxidant
response
element
(ARE)
region
present
promoter
several
genes
such
as
heme
oxygenase,
catalase,
glutathione
peroxidase
superoxide
dismutase
neutralize
ROS,
damages.
this
review,
we
analyze
current
literature
regarding
preeclamptic
pregnancies,
discussing
main
cellular
modulators
pathway.
Moreover,
discuss
natural
synthetic
compounds
can
regulate
vivo
vitro
models.
Sensors,
Год журнала:
2022,
Номер
22(15), С. 5652 - 5652
Опубликована: Июль 28, 2022
Skin
cancer
is
a
deadly
disease,
and
its
early
diagnosis
enhances
the
chances
of
survival.
Deep
learning
algorithms
for
skin
detection
have
become
popular
in
recent
years.
A
novel
framework
based
on
deep
proposed
this
study
multiclassification
types
such
as
Melanoma,
Melanocytic
Nevi,
Basal
Cell
Carcinoma
Benign
Keratosis.
The
model
named
SCDNet
which
combines
Vgg16
with
convolutional
neural
networks
(CNN)
classification
different
cancer.
Moreover,
accuracy
method
also
compared
four
state-of-the-art
pre-trained
classifiers
medical
domain
Resnet
50,
Inception
v3,
AlexNet
Vgg19.
performance
classifier,
well
classifiers,
evaluated
using
ISIC
2019
dataset.
rate
SDCNet
96.91%
whereas,
rates
Alexnet,
Vgg19
Inception-v3
are
95.21%,
93.14%,
94.25%
92.54%,
respectively.
results
showed
that
performed
better
than
competing
classifiers.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(9), С. 7839 - 7839
Опубликована: Апрель 25, 2023
Ovarian
cancer
is
one
of
the
most
dangerous
gynecologic
malignancies
showing
a
high
fatality
rate
because
late
diagnosis
and
relapse
occurrence
due
to
chemoresistance
onset.
Several
researchers
reported
that
oxidative
stress
plays
key
role
in
ovarian
occurrence,
growth
development.
The
NAD(P)H:quinone
oxidoreductase
1
(NQO1)
an
antioxidant
enzyme
that,
using
NADH
or
NADPH
as
substrates
reduce
quinones
hydroquinones,
avoids
formation
highly
reactive
semiquinones,
then
protecting
cells
against
stress.
In
this
review,
we
report
evidence
from
literature
describing
effect
NQO1
on
onset
progression.
Biomolecules,
Год журнала:
2023,
Номер
13(2), С. 353 - 353
Опубликована: Фев. 11, 2023
The
imbalance
between
reactive
oxygen
species
(ROS)
production
and
clearance
causes
oxidative
stress
ROS,
which
play
a
central
role
in
regulating
cell
tissue
physiology
pathology.
Contingent
upon
concentration,
ROS
influence
cancer
development
contradictory
ways,
either
stimulating
survival
growth
or
causing
death.
Cells
developed
evolutionarily
conserved
programs
to
sense
adapt
redox
the
fluctuations
regulate
as
signaling
molecules
toxic
insults.
transcription
factor
nuclear
erythroid
2-related
2
(NRF2)-KEAP1
system
is
master
regulator
of
cellular
metabolic
homeostasis.
NRF2
has
Janus-like
roles
carcinogenesis
development.
Short-term
activation
suppresses
injury,
inflammation,
initiation.
However,
cells
often
exhibit
constitutive
due
genetic
mutations
oncogenic
signaling,
conferring
advantages
for
cells'
growth.
Emerging
evidence
suggests
that
hyperactivation,
an
adaptive
phenotype
under
stressful
tumor
environments,
regulates
all
hallmarks
cancer.
In
this
review,
we
summarized
source
regulation
sensors
(O2),
reviewed
recent
progress
on
generation
with
focus
new
functions
reach
beyond
what
originally
envisioned,
including
metabolism,
autophagy,
macropinocytosis,
unfolded
protein
response,
proteostasis,
circadian
rhythm,
which,
together
anti-oxidant
drug
detoxification
enzymes,
contributes
development,
metastasis,
anticancer
therapy
resistance.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(1), С. 587 - 587
Опубликована: Янв. 2, 2024
Ovarian
cancer
is
one
of
the
most
dangerous
gynecologic
cancers
worldwide
and
has
a
high
fatality
rate
due
to
diagnosis
at
an
advanced
stage
disease
as
well
recurrence
occurrence
chemotherapy
resistance.
In
fact,
chemoresistance
weakens
therapeutic
effects,
worsening
outcome
this
pathology.
Solute
Carrier
Family
7
Member
11
(SLC7A11,
also
known
xCT)
functional
subunit
Xc−
system,
anionic
L-cystine/L-glutamate
antiporter
expressed
on
cell
surface.
SLC7A11
expression
significantly
upregulated
in
several
types
which
it
can
inhibit
ferroptosis
favor
proliferation,
invasion
chemoresistance.
increased
ovarian
tissues,
suggesting
possible
role
protein
target.
review,
we
provide
overview
current
literature
regarding
new
insights
modulation
evaluate
potential
Cells,
Год журнала:
2023,
Номер
12(13), С. 1778 - 1778
Опубликована: Июль 4, 2023
CD93
(also
known
as
complement
protein
1
q
subcomponent
receptor
C1qR1
or
C1qRp),
is
a
transmembrane
glycoprotein
encoded
by
gene
located
on
20p11.21
and
composed
of
652
amino
acids.
can
be
present
in
two
forms:
soluble
(sCD93)
membrane-bound
(CD93).
mainly
expressed
endothelial
cells,
where
it
plays
key
role
promoting
angiogenesis
both
physiology
disease,
such
age-related
macular
degeneration
tumor
angiogenesis.
In
fact,
highly
tumor-associated
vessels
its
presence
correlates
with
poor
prognosis,
immunotherapy
response,
immune
cell
infiltration
high
tumor,
node
metastasis
(TNM)
stage
many
cancer
types.
also
hematopoietic
stem
cytotrophoblast
platelets
i.e.,
monocytes,
neutrophils,
B
cells
natural
killer
(NK)
cells.
Accordingly,
involved
modulating
important
inflammatory-associated
diseases
including
systemic
sclerosis
neuroinflammation.
Finally,
cardiovascular
disease
development
progression.
this
article,
we
reviewed
the
current
literature
regarding
angiogenesis,
inflammation
growth
order
to
understand
could
potential
therapeutic
target
modify
outcome
abovementioned
pathologies.
