Therapeutic application of natural products: NAD+ metabolism as potential target

Phytomedicine, Год журнала: 2023, Номер 114, С. 154768 - 154768

Опубликована: Март 13, 2023

Язык: Английский

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Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR‐1236/HER2 signaling pathway

MedComm, Год журнала: 2023, Номер 4(3)

Опубликована: Май 26, 2023

In the central nervous system diseases, glioma is one of most common malignancies around world. Despite recent improvements in therapies for glioma, prognosis some high-risk remains poor. isoliquiritigenin (ISL) reported to have antioxidative and antitumor activities. However, potential mechanisms between ISL circle RNAs (circRNAs) tumorigenesis process not yet been reported. Here, we treated cells with ISL, circRNA expression levels were detected. Circ0030018 was found significantly downregulated by ISL. Therefore, explored circ0030018 profiles functions finding that evidently overexpressed cell lines. Colony formation, CCK-8, transwell assay made clear silencing dramatically cut down growth invasion. Moreover, ROS level detected find silence remarkably enhanced oxidative stress glioma. Mechanism studies conducted investigate underlying basis function unveiling realized its partially through miR-1236/HER2 signaling conclusion, our study investigated roles on circ0030018/miR-1236/HER2 pathway progression. could act as prospective biologic signature or therapeutic target

Язык: Английский

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Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions

Antioxidants, Год журнала: 2023, Номер 12(2), С. 428 - 428

Опубликована: Фев. 9, 2023

Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or maintain homeostasis survival. It typically observed nutrient-deprived cells as survival mechanism. However, it has also been identified crucial maintaining disease progression. Normal metabolism produces reactive oxygen (ROS) nitrogen species at low levels. increased production causes oxidative stress, can lead diabetes, cardiovascular diseases, neurological disorders, cancer. was recently shown that redox equilibrium via autophagy critical for responses stress. little understood about the molecular cancer processes connect control of autophagy. In cells, oncogenic mutations, carcinogens, metabolic reprogramming cause ROS generation Recent studies have suggested activates pathways promote development metastasis. Moreover, relationship between programming involved malignant phenotype. Currently, while signaling events governing how affects cascades well understood, very known related this review, we focus on current knowledge modulation role further stress progression regulation. Therefore, review focuses understanding oxidation/reduction fine-tune help understand govern cancer, either leading cell death strategies

Язык: Английский

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NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1

Cell Reports, Год журнала: 2024, Номер 43(1), С. 113654 - 113654

Опубликована: Янв. 1, 2024

Deficiency of DNA repair pathways drives the development colorectal cancer. However, role base excision (BER) pathway in cancer initiation remains unclear. This study shows that Nei-like glycosylase 1 (NEIL1) is highly expressed (CRC) tissues and associated with poorer clinical outcomes. Knocking out neil1 mice markedly suppresses tumorigenesis enhances infiltration CD8+ T cells intestinal tumors. Furthermore, NEIL1 directly forms a complex SATB2/c-Myc to enhance transcription COL17A1 subsequently promotes production immunosuppressive cytokines CRC cells. A peptide ApcMin/+ mice, targeting demonstrates synergistic suppressive effect on tumor growth when combined nuclear factor κB (NF-κB) inhibitor. These results suggest NF-κB may represent promising strategy for therapy.

Язык: Английский

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Mechanisms of Sepsis-Induced Acute Lung Injury and Advancements of Natural Small Molecules in Its Treatment

Pharmaceuticals, Год журнала: 2024, Номер 17(4), С. 472 - 472

Опубликована: Апрель 8, 2024

Sepsis-induced acute lung injury (ALI), characterized by widespread dysfunction, is associated with significant morbidity and mortality due to the lack of effective pharmacological treatments available clinically. Small-molecule compounds derived from natural products represent an innovative source have demonstrated therapeutic potential against sepsis-induced ALI. These small molecules may provide a promising alternative treatment option for This review aims summarize pathogenesis sepsis targets. It assembles critical updates (from 2014 2024) on ALI, detailing their sources, structures, effects, mechanisms action.

Язык: Английский

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Glycyrrhizin and its derivatives: an emerging secondary metabolite arsenal of Glycyrrhiza glabra

Medicinal Chemistry Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Язык: Английский

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A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12091 - 12091

Опубликована: Ноя. 11, 2024

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.

Язык: Английский

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Anti-obesity effect of isoliquiritigenin in the 3T3-L1 cell line and a high-fat diet-induced obesity mice model

Journal of Functional Foods, Год журнала: 2025, Номер 127, С. 106735 - 106735

Опубликована: Март 22, 2025

Язык: Английский

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Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1616 - 1616

Опубликована: Фев. 14, 2025

Brown adipose tissue (BAT) is a critical regulator of non-shivering thermogenesis and energy expenditure, offering significant potential for addressing obesity associated metabolic disorders. Isoliquiritigenin (ISL), natural flavonoid, has shown promising therapeutic effects in lipid metabolism-related diseases. This study aimed to explore the ISL on metabolism using high-fat-diet (HFD)-induced model mice. Mice were subjected an HFD treated with via gavage. The results demonstrated that treatment significantly reduced HFD-induced weight gain upregulated expression key thermogenic genes, suggesting enhanced BAT activity thermogenesis. In vitro experiments C3H10-T1/2 cells further supported these findings, as markedly increased UCP1 PPARGC1a, which are regulators To elucidate molecular mechanisms underlying ISL's effects, we conducted transcriptomic analysis from ISL-treated Pathway enrichment revealed differentially expressed genes predominantly processes, including tricarboxylic acid (TCA) cycle, oxidative phosphorylation, fatty degradation. These pathways integral thermogenesis, providing mechanistic insights into anti-obesity effects. Additionally, downregulated NNAT SGK1, implicated homeostasis. findings suggest modulates function by regulating thereby influencing deposition capacity. summary, this suggests mitigate promoting modulating metabolism. involve regulation such highlighting agent related

Язык: Английский

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T helper cell 17/regulatory T cell balance regulates ulcerative colitis and the therapeutic role of natural plant components: a review

Frontiers in Medicine, Год журнала: 2025, Номер 11

Опубликована: Март 24, 2025

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease characterized by progressive mucosal damage. The incidence rate of UC rising rapidly, which makes the burden medical resources aggravated. In UC, due to various pathogenic factors such as immune system disorders, gene mutations and environmental disrupting barrier function, midgut bacteria exogenous antigens translocate into lamina propria, thereby aggravating response further damages barrier. During progression Th17 populations that cause inflammation generally increase, while Tregs suppress activity decrease. Among them, mediates response, Treg immunosuppression, coordinated balance two plays key role in process UC. Natural plant components can regulate biological processes from multiple levels proinflammatory cytokines signaling pathways. These characteristics have unique advantages broad prospects treatment immunomodulation, there substantial clinical experimental evidence for modulatory natural products restoring between Th17/Treg disturbances This review summarizes previous studies on regulation active ingredients, extracts, traditional Chinese medicine prescriptions, provides new development design lead compounds drugs future, then ideas future intervention disorders trials.

Язык: Английский

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