Translational Psychiatry, Год журнала: 2023, Номер 13(1)
Опубликована: Июль 24, 2023
Abstract Previous observational studies reported that midlife clustering of cardiovascular risk factors and lifestyle behaviors were associated with neurodegenerative disease; however, these findings might be biased by confounding reverse causality. This study aimed to investigate the causal associations disease, using two-sample Mendelian randomization design. Genetic variants for modifiable disease extracted from large-scale genome-wide association studies. The inverse-variance weighted method was used as main analysis method, MR-Egger regression leave-one-out analyses performed identify potential violations. Genetically predicted diastolic blood pressure (DBP: OR per 1 mmHg, 0.990 [0.979–1.000]), body mass index (BMI: SD, 0.880 [0.825–0.939]), educational level (OR 0.698 [0.602–0.810]) lower late-onset Alzheimer’s (LOAD), while genetically low-density lipoprotein (LDL: 1.302 [1.066–1.590]) increase LOAD risk. exposures (including LDL BMI) applied familial AD showed same effect. also found Amyotrophic lateral sclerosis (ALS) 1.180 [1.080–1.289]). MR LDL, BMI, BP, causally related AD; a significant between ALS risk, well effect sleep duration on PD revealed. Targeting promising strategy prevention.
Язык: Английский
Процитировано
9Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6587 - 6587
Опубликована: Апрель 1, 2023
Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated integrate into existing neuronal circuits to participate different tasks. Despite that protect mammalian brain, this organ is susceptible many types of damage result loss tissue and therefore alterations functionality affected regions. Nevertheless, has developed respond these injuries, potentiating its capacity new altering processes occur niches. may lead generation damaged Notwithstanding, activation repair mechanisms, regeneration injuries does not naturally occur. In review, we discuss how niches focusing on progenitors migrate injured regions activate mechanisms. We conclude search for pharmacological drugs stimulate migration development therapies tissue.
Язык: Английский
Процитировано
7GABA-transaminase: A Key Player and Potential Therapeutic Target for Neurological Disorders
Central Nervous System Agents in Medicinal Chemistry, Год журнала: 2024, Номер 24(1), С. 57 - 67
Опубликована: Янв. 21, 2024
Abstract: Neurological disorders such as epilepsy, autism, Huntington's disease, multiple sclerosis, and Alzheimer's disease alter brain functions like cognition, mood, movements, language, severely compromising the well-being of persons, suffering from their negative effects. The neurotransmitters (GABA, glutamate, norepinephrine, dopamine) are found to be involved in neuronal signaling neurotransmission. GABA, a "commanding neurotransmitter" is directly or indirectly associated with various neurological disorders. GABA metabolized succinic semialdehyde by mitochondrial gamma-aminobutyric acid-transaminase (GABA-T) enzyme. Therefore, alterations performance distinct regions via GABA-T overstimulation inhibition would play vital role pathogenesis This review emphasizes leading participation sclerosis. In surfeited results diminished levels whereas subsidence activity causes elevation contents, which responsible for behavioral changes these inhibitors (in sclerosis) agonists autism) can used therapeutically. context some researchers favor stimulation disagree it. concerning still unclear. this way, studies enzymatic contrast could undertaken understand considered therapeutic target several GABA-ergic CNS diseases.
Язык: Английский
Процитировано
2INVASIVE PLANTS AS A SUSTAINABLE SOURCE OF BIOMOLECULES AGAINST NEURODEGENERATIVE DISEASES
International Journal of Health Science, Год журнала: 2024, Номер 4(16), С. 2 - 10
Опубликована: Фев. 7, 2024
The development of neurodegenerative diseases is strongly related to oxidative stress, due an imbalance in cellular metabolism.There are currently different therapies available treat these diseases, although they often not curative and/or have adverse effects.In view the above, it necessary find complementary alternative medicines that replace current treatments, showing fewer side effects.Secondary metabolites synthesized by invasive plants, specifically phenolic compounds, a great capacity suppress neutralizing free radicals.Thus, compounds can be used as pharmacological treatments for pathological conditions associated with increased stress.Currently, species considered one greatest threats preservation biodiversity world, causing negative impacts at both environmental and socioeconomic level.Therefore, imperative measures implemented control manage them, ensuring balanced ecosystem and, same time, promoting sustainable economy.The use extraction bioactive from plants possible applications field medicine futuristic strategy, aiming implement 2030 Agenda some objectives.
Язык: Английский
Процитировано
2Emerging Nanozymes in Neurological Disorder Therapeutics: Bridging Oxidoreductase Mimicry and Antioxidant Chemistry
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Июль 3, 2024
Abstract The prevalence of neurological dieases, including neurodegenerative, neurotraumatic disorders, and neuroinflammatory conditions, has been rising due to global population aging demographics. A key factor in the pathogenesis these disorders is hyperaccumulation reactive oxygen nitrogen species (RONS). Nanozymes have emerged as promising candidates for neurotherapeutic applications owing their exceptional catalytic activity stability. Of particular note ability cross blood‐brain barrier counteract production via enzyme‐mimicking characteristics. In this review, latest advancements theoretical knowledge research domain are summarized. Using inherent functionalities Web Science bibliometric methodologies, annual publication trends identified extensively explored most researched topics field. antioxidant reduction chemistry nanozymes discussed, highlighting mimic natural oxidoreductase inhibit RONS at source. Moreover, review delves into current limitations future prospects mechanisms addressing disorders. significant benefits recent developments use RONS‐regulating treatment diseases emphasized, offering insights therapeutic broader implications neurology.
Язык: Английский
Процитировано
2Plasma and cerebrospinal fluid nonenzymatic protein damage is sustained in Alzheimer's disease
Redox Biology, Год журнала: 2023, Номер 64, С. 102772 - 102772
Опубликована: Июнь 4, 2023
Oxidative stress is considered to play an important role in the pathogenesis of Alzheimer's disease (AD). It has been observed that oxidative damage specific protein targets affecting particular functional networks one mechanisms by which contributes neuronal failure and consequently loss cognition AD progression. Studies are lacking measured at both systemic central fluid levels same cohort patients. We aimed determine plasma cerebrospinal (CSF) nonenzymatic patients continuum evaluate relation this with clinical progression from mild cognitive impairment (MCI) AD.Different markers post-translational modification, mostly processes, were detected quantified CSF isotope dilution gas chromatography‒mass spectrometry using selected ion monitoring (SIM-GC/MS) for 289 subjects: 103 AD, 92 MCI, 94 control subjects. Characteristics study population such as age, sex, Mini-mental state examination, biomarkers, APOE ϵ4, also considered.Forty-seven (52.8%) MCI progressed during follow-up (58 ± 12.5 months). After controlling ϵ4 allele, concentrations not associated either diagnosis or MCI. The none biomarkers. In addition, neither nor progression.The lack association between suggests a pathogenic mechanism specifically expressed cell-tissue level, extracellular fluids.
Язык: Английский
Процитировано
6Frog-derived peptides and neuroprotection
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 415 - 436
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1Neuroprotective actions of norepinephrine in neurological diseases
Pflügers Archiv - European Journal of Physiology, Год журнала: 2024, Номер 476(11), С. 1703 - 1725
Опубликована: Авг. 13, 2024
Язык: Английский
Процитировано
1
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(9)
Опубликована: Сен. 1, 2024
Type 2 diabetes mellitus (T2DM) is related to an increased risk of postoperative cognitive dysfunction (POCD), which may be caused by neuronal hyperexcitability. Astrocyte glutamate transporter 1 (GLT-1) plays a crucial role in regulating neuron excitability. We investigated if T2DM would magnify the excitability induced anesthesia/surgery (A/S) and lead POCD young adult mice, so, determined whether these effects were associated with GLT-1 expression.
Язык: Английский
Процитировано
1Morning Antioxidants: Molecular Insights on the Chemistry of Coffee Components
Опубликована: Июнь 29, 2023
Coffee is not only a delicious beverage but also an important dietary source of natural antioxidants. We live in oxidative world where it impossible to avoid pollution, stress, food additives, radiation, and other sources oxidants that eventually lead severe health disorders. Fortunately, there are chemicals our diet counteract the hazards posed by reactive species trigger stress. They usually referred as antioxidants; some them can be versatile compounds exert such role various ways. This review summarizes, from chemical point view, antioxidant effects relevant molecules found coffee. Their ways action trends activity analyzed, considering data gathered so far both theory experiments. The influence media pH aqueous solution, structure-activity relationships discussed. protective explored examined. A particular section devoted derivatives coffee components, another one their bioactivity. used analysis come theoretical anc computational protocols, which have been proven very usefull this context. Hopefully, information provided here will promote further investigations into amazing chemistry contained morning cup.
Язык: Английский
Процитировано
2