Therapeutic Activity of Green Tea Epigallocatechin-3-Gallate on Metabolic Diseases and Non-Alcoholic Fatty Liver Diseases: The Current Updates

Nutrients, Год журнала: 2023, Номер 15(13), С. 3022 - 3022

Опубликована: Июль 3, 2023

Green tea polyphenols have numerous functions including antioxidation and modulation of various cellular proteins are thus beneficial against metabolic diseases obesity, type 2 diabetes, cardiovascular non-alcoholic fatty liver diseases, their comorbidities. Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green attributed to antioxidant free radical scavenging activities, likelihood targeting multiple pathways. It has been shown exhibit anti-obesity, anti-inflammatory, anti-diabetic, anti-arteriosclerotic, weight-reducing effects humans. Worldwide, incidences escalating across all age groups modern society. Therefore, EGCG being increasingly investigated address problems. This review presents current updates on highlights evidence related its safety. Collectively, this brings more for therapeutic application further studies derivatives alleviate diseases.

Язык: Английский

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Anti-Inflammatory Effect of Ebractenoid F, a Major Active Compound of Euphorbia ebracteolata Hayata, through Inhibition of Nuclear Factor-κB Activation

Plants, Год журнала: 2023, Номер 12(15), С. 2845 - 2845

Опубликована: Авг. 1, 2023

Euphorbia ebracteolata Hayata (Euphorbiaceae family) is a perennial plant that widely distributed in Korea, Japan, and China. Its roots contain bioactive diterpenes have anti-inflammatory properties. However, the mechanisms are not yet fully understood. This study aimed to identify most active compound from of E. Hayata, using bioassay-guided fractionation combinative method high-speed countercurrent chromatography (HSCCC) preparative high-performance liquid (HPLC). Then, we investigated its mechanism lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Ebractenoid F was identified as potent Hayata. significantly decreased nitric oxide (NO) production nuclear factor-κB (NF-κB) activation induced by LPS Moreover, ebractenoid degradation inhibitory κB-α, translocation p65 p50 subunits NF-κB, expression NF-κB downstream genes. Furthermore, inhibited phosphorylation Akt mitogen-activated protein kinases (MAPKs), such extracellular signal-regulated kinase (ERK) c-Jun NH2 terminal (JNK), LPS-stimulated cells. In conclusion, exerts effect suppressing NF-κB-mediated NO may be useful therapeutic for prevention or treatment inflammation-associated diseases.

Язык: Английский

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L-Arginine and Nitric Oxide in Vascular Regulation—Experimental Findings in the Context of Blood Donation

Nutrients, Год журнала: 2025, Номер 17(4), С. 665 - 665

Опубликована: Фев. 13, 2025

This narrative review provides an analysis of the role nitric oxide (NO) and its precursors, particularly L-arginine, in vascular regulation health, with emphasis on findings from our experimental research animal models. NO serves as a critical mediator function, contributing to vasodilation, blood flow, prevention thrombosis. As primary precursor NO, L-arginine is essential for maintaining endothelial integrity, modulating mitochondrial reducing oxidative damage. synthesises data contextualises these within physiological challenges faced by donors, such repeated donation associated stress. It examines effects supplementation respiration, lipid peroxidation, microsomal oxidation different conditions, including differences age, gender, dietary interventions. The mechanisms which enhances production, improves elasticity, alleviates dysfunction caused reduced bioavailability are also investigated. By integrating insights existing literature, this perspective potential address specific needs donors. highlights importance personalised nutritional approaches enhancing donor recovery resilience. In addition, assesses wider implications mitigating stress preserving function. interplay between bioavailability, factors, adaptation donors highlighted, along identification current knowledge gaps recommendations future research. presenting both original evidence synthesis article therapeutic promoting health context donation.

Язык: Английский

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Passivation protein-adhesion platform promoting stent reendothelialization using two-electron-assisted oxidation of polyphenols

Biomaterials, Год журнала: 2023, Номер 305, С. 122423 - 122423

Опубликована: Дек. 16, 2023

Язык: Английский

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Protective Effects of Carvacrol on Mercuric Chloride‐Induced Lung Toxicity Through Modulating Oxidative Stress, Apoptosis, Inflammation, and Autophagy

Environmental Toxicology, Год журнала: 2024, Номер 39(12), С. 5227 - 5237

Опубликована: Авг. 6, 2024

ABSTRACT Mercuric chloride (HgCl 2 ) is extremely toxic to both humans and animals. It could be absorbed via ingestion, inhalation, skin contact. Exposure HgCl can cause severe health effects, including damages the gastrointestinal, respiratory, central nervous systems. The purpose of this work was explore if carvacrol (CRV) protect rats lungs from damage caused by . Intraperitoneal injections at a dose 1.23 mg/kg body weight were given either alone or in conjunction with oral CRV administration doses 25 50 for 7 days. study included biochemical histological techniques examine lung tissue's oxidative stress, apoptosis, inflammation, autophagy processes. ‐induced reductions GSH levels antioxidant enzymes (SOD, CAT, GPx) activity enhanced co‐administration. Furthermore, MDA lowered CRV. inflammatory mediators NF‐κB, IκB, NLRP3, TNF‐α, IL‐1β, IL6, COX‐2, iNOS all reduced When exposed , apoptotic Bax, caspase‐3, Apaf1, p53, caspase‐6, caspase‐9 increased, but antiapoptotic Bcl‐2 after treatment. decreased Beclin‐1, LC3A, LC3B, which turn damage. After treatment, higher pathological observed terms alveolar septal thickening, congestion, edema, cell infiltration compared control group while ameliorated these effects. Consequently, preventing increases stress corresponding autophagy, disturbance tissue integrity tissues, might seen as useful therapeutic alternative.

Язык: Английский

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Polyphenols and Cardiometabolic Health: Knowledge and Concern among Romanian People

Nutrients, Год журнала: 2023, Номер 15(10), С. 2281 - 2281

Опубликована: Май 12, 2023

The cardiometabolic health of the population is a crucial indicator public health, considering significant impact cardiovascular disease (CVD) and diabetes on global mortality. Determining population's knowledge predictors these pathologies essential in developing effective educational clinical strategies for prevention management risk (CMR). Polyphenols are natural compounds with multitude beneficial effects health. This study explored current knowledge, understanding, awareness CMR, benefits polyphenols among Romanians, how sociodemographic characteristics influence this aspect. Five hundred forty-six subjects responded anonymously to an online questionnaire designed assess their knowledge. data were collected analyzed based gender, age, education level, BMI status. Most respondents expressed concern great or very extent about (78%) food (60%), differences (

Язык: Английский

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Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 16, 2024

Nao-an Dropping Pill (NADP) is a Chinese patent medicine which commonly used in clinic for ischemic stroke (IS). However, the material basis and mechanism of its prevention or treatment IS are unclear, then we carried out this study. 52 incoming blood components were resolved by UHPLC-MS/MS from rat serum, including 45 prototype components. The potential active hydroxysafflor yellow A, ginsenoside F1, quercetin, ferulic acid caffeic screened network pharmacology showed strongly binding ability with PIK3CA, AKT1, NOS3, NFE2L2 HMOX1 molecular docking. In vitro oxygen-glucose deprivation/reperfusion (OGD/R) experimental results that NADP protected HA1800 cells OGD/R-induced apoptosis affecting release LDH, production NO, content SOD MDA. Meanwhile, could improve behavioral middle cerebral artery occlusion/reperfusion (MCAO/R) rats, reduce area cortex, decrease brain water glutamate (Glu) content, oxidative stress response. Immunohistochemical significantly regulated expression PI3K, Akt, p-Akt, eNOS, p-eNOS, Nrf2 HO-1 tissues. suggested protects tissues ameliorates damage to regulating PI3K/Akt/eNOS Nrf2/HO-1 signaling pathways.

Язык: Английский

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Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases

Pharmacological Reports, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Язык: Английский

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Potential Anti-ulcerogenic Effect of Troxerutin in Ethanol-induced Gastric Lesions in Mice: Anti-inflammatory and Antioxidant Mechanisms and Possible Action Pathways

Revista Brasileira de Farmacognosia, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Sport: Improving exercise performance with polyphenol extracts

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 149 - 176

Опубликована: Янв. 1, 2025

Язык: Английский

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