Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 10, 2025
Previous
studies
have
shown
that
epigallocatechin-3-gallate
(EGCG),
the
most
abundant
catechin
in
green
tea,
demonstrates
promising
antiobesity
effects.
While
autophagy
mediates
obesity
via
preadipocyte
differentiation
and
lipogenesis,
EGCG's
potential
autophagy-dependent
mechanism
remains
unclear.
We
used
3T3-L1
cells
high-fat-diet
(HFD)-fed
mice
to
examine
how
EGCG
inhibits
adipogenesis
lipogenesis
autophagy.
(50
or
100
mg/kg)
significantly
attenuated
HFD-induced
weight
gain,
fat
accumulation,
hyperlipidemia,
glucose
intolerance
mice.
It
also
enhanced
lipolysis
white
adipose
tissue
(WAT).
profoundly
inhibited
terminal
lipid
droplet
formation
accompanied
by
reduced
PPARγ,
C/EBPα,
FASN
expressions.
Mechanistically,
during
early
stage
of
differentiation,
as
evidenced
increased
autophagosome
accumulation
impaired
autophagic
flux.
The
antiadipogenic
effect
was
further
aggravated
inhibitor
chloroquine.
Meanwhile,
p38
AMPK/ACC
phosphorylation
while
inhibiting
JNK
at
an
adipogenesis.
Interestingly,
expression
lipolytic
enzymes
HSL
ATGL,
it
decreased
glycerol
contents
differentiated
cells.
These
findings
provide
novel
insights
into
using
tea
functional
foods
combat
targeting
lipolysis.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 1, 2024
Catechins,
a
class
of
phytochemicals
found
in
various
fruits
and
tea
leaves,
have
garnered
attention
for
their
diverse
health-promoting
properties,
including
potential
combating
neurodegenerative
diseases.
Among
these
catechins,
(-)-epigallocatechin-3-gallate
(EGCG),
the
most
abundant
polyphenol
green
tea,
has
emerged
as
promising
therapeutic
agent
due
to
its
potent
antioxidant
anti-inflammatory
effects.
Chronic
neuroinflammation
oxidative
stress
are
key
pathological
mechanisms
diseases
such
Alzheimer's
disease
(AD)
Parkinson's
(PD).
EGCG
neuroprotective
efficacy
scavenging
free
radicals,
reducing
attenuating
neuroinflammatory
processes.
This
review
discusses
molecular
EGCG's
anti-oxidative
chronic
neuroinflammation,
emphasizing
effects
on
autoimmune
responses,
neuroimmune
system
interactions,
focusing
related
AD
PD.
By
elucidating
action
impact
processes,
this
underscores
intervention
AD,
PD,
possibly
other
Overall,
emerges
natural
compound
stress,
offering
novel
avenues
strategies
treatment
disorders.
Biomedicines,
Год журнала:
2024,
Номер
12(4), С. 826 - 826
Опубликована: Апрель 9, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
major
public
health
issue
worldwide.
It
the
most
common
in
Western
countries,
andits
global
prevalence
estimated
to
be
up
35%.
However,
its
diagnosis
may
elusive,
because
biopsy
relatively
rarely
performed
and
usually
only
advanced
stages
of
disease.
Therefore,
several
non-invasive
scores
applied
more
easily
diagnose
monitor
NAFLD.
In
this
review,
we
discuss
various
biomarkers
imaging
that
could
useful
diagnosing
managing
Despite
fact
general
measures,
such
as
abstinence
from
alcohol
modulation
other
cardiovascular
risk
factors,
should
applied,
mainstay
prevention
management
weight
loss.
Bariatric
surgery
suggested
means
confront
addition,
pharmacological
treatment
with
GLP-1
analogues
or
GIP
agonist
tirzepatide
advisable.
focus
on
utility
agonists
lowering
body
weight,
their
pharmaceutical
potential,
safety
profile,
already
evidenced
inanimal
human
studies.
We
also
elaborate
options,
use
vitamin
E,
probiotics,
especially
next-generation
prebiotics
context.
Finally,
explore
future
perspectives
regarding
administration
analogues,
agonists,
probiotics/prebiotics
prevent
combat
The
newest
drugs
pegozafermin
resmetiron,
which
seem
very
promising,
arealso
discussed.
Biomolecules,
Год журнала:
2025,
Номер
15(1), С. 140 - 140
Опубликована: Янв. 17, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
has
become
the
most
common
chronic
and
is
closely
associated
with
metabolic
diseases
such
as
obesity,
type
2
diabetes
mellitus
(T2DM),
syndrome.
However,
effective
treatment
strategies
for
NAFLD
are
still
lacking.
In
recent
years,
progress
been
made
in
understanding
pathogenesis
of
NAFLD,
identifying
multiple
therapeutic
targets
providing
new
directions
drug
development.
This
review
summarizes
advances
focusing
on
mechanisms
action
natural
products,
small-synthetic-molecule
drugs,
combination
therapy
strategies.
aims
to
provide
insights
treating
NAFLD.
Antioxidants,
Год журнала:
2025,
Номер
14(2), С. 203 - 203
Опубликована: Фев. 10, 2025
The
interplay
between
oxidative
stress
and
adipogenesis
is
a
critical
factor
in
the
development
of
obesity
its
associated
metabolic
disorders.
Excessive
reactive
oxygen
species
(ROS)
disrupt
key
transcription
factors
such
as
peroxisome
proliferator-activated
receptor
gamma
(PPARγ)
CCAAT/enhancer-binding
protein
alpha
(C/EBPα),
impairing
lipid
metabolism,
promoting
adipocyte
dysfunction,
exacerbating
inflammation
insulin
resistance.
Antioxidants,
classified
endogenous
(e.g.,
glutathione,
superoxide
dismutase,
catalase)
exogenous
polyphenols,
flavonoids,
vitamins
C
E),
are
pivotal
mitigating
these
effects
by
restoring
redox
balance
preserving
functionality.
Endogenous
antioxidants
neutralize
ROS
safeguard
cellular
structures;
however,
under
heightened
stress,
defenses
often
insufficient,
necessitating
dietary
supplementation.
Exogenous
derived
from
plant-based
sources,
polyphenols
vitamins,
act
through
direct
scavenging,
upregulation
antioxidant
enzymes,
modulation
signaling
pathways
like
nuclear
kappa
B
(NF-κB)
PPARγ,
reducing
peroxidation,
inflammation,
dysfunction.
Furthermore,
they
influence
epigenetic
regulation
transcriptional
networks
to
restore
differentiation
limit
accumulation.
Antioxidant-rich
diets,
including
Mediterranean
diet,
strongly
with
improved
health,
reduced
rates,
enhanced
sensitivity.
Advances
personalized
therapies,
guided
biomarkers
supported
novel
delivery
systems,
present
promising
avenues
for
optimizing
therapeutic
interventions.
This
review,
"Crosstalk
Between
Antioxidants
Adipogenesis:
Mechanistic
Pathways
Their
Role
Metabolic
Health",
highlights
mechanistic
which
regulate
enhance
health.
Nutrients,
Год журнала:
2024,
Номер
16(3), С. 427 - 427
Опубликована: Янв. 31, 2024
In
recent
decades,
following
the
spread
of
obesity,
metabolic
dysfunction
has
come
to
represent
leading
cause
liver
disease.
The
classical
clinical
presentation
cirrhotic
patient
has,
therefore,
greatly
changed,
with
a
dramatic
increase
in
subjects
who
appear
overweight
or
obese.
Due
an
obesogenic
lifestyle
(lack
physical
activity
and
overall
malnutrition,
excess
caloric
intake
together
deficit
proteins
micronutrients),
these
patients
frequently
develop
complex
condition
defined
as
sarcopenic
obesity
(SO).
interplay
between
cirrhosis
SO
lies
sharing
multiple
pathogenetic
mechanisms,
including
malnutrition/malabsorption,
chronic
inflammation,
hyperammonemia
insulin
resistance.
presence
worsens
outcome
patients,
affecting
morbidity
mortality.
International
nutrition
diseases
societies
strongly
agree
on
recommending
use
food
integral
part
healing
process
comprehensive
management
reduction
intake,
protein
micronutrient
supplementation
sodium
restriction.
Based
pathophysiological
paths
shared
by
SO,
this
narrative
review
aims
highlight
nutritional
interventions
currently
advocated
international
guidelines,
well
provide
hints
possible
role
micronutrients
nutraceuticals
treatment
multifaceted
condition.
Nutrients,
Год журнала:
2025,
Номер
17(7), С. 1101 - 1101
Опубликована: Март 21, 2025
The
liver,
as
the
primary
metabolic
organ,
is
susceptible
to
an
array
of
factors
that
can
harm
liver
cells
and
give
rise
different
diseases.
Epigallocatechin
gallate
(EGCG),
a
natural
compound
found
in
green
tea,
exerts
numerous
beneficial
effects
on
human
body.
Notably,
EGCG
displays
antioxidative,
antibacterial,
antiviral,
anti-inflammatory,
anti-tumor
properties.
This
review
specifically
highlights
pivotal
role
liver-related
diseases,
focusing
viral
hepatitis,
autoimmune
fatty
disease,
hepatocellular
carcinoma.
not
only
inhibits
entry
replication
hepatitis
B
C
viruses
within
hepatocytes,
but
also
mitigates
hepatocytic
damage
caused
by
hepatitis-induced
inflammation.
Furthermore,
exhibits
significant
therapeutic
potential
against
Combinatorial
use
anti-hepatocellular
carcinoma
drugs
enhances
sensitivity
drug-resistant
cancer
chemotherapeutic
agents,
leading
improved
outcomes.
Thus,
combination
holds
promise
effective
approach
for
treating
In
conclusion,
possesses
hepatoprotective
properties
various
forms
emerges
drug
candidate
The
prevalence
and
incidence
of
obesity
the
comorbidities
linked
to
it
are
increasing
in
world
population.
Current
therapies
for
associated
pathologies
have
proven
cause
a
broad
number
adverse
effects
often,
they
overpriced
or
not
affordable
all
patients.
Among
alternatives
currently
available,
natural
bioactive
compounds
stand
out.
These
frequently
contained
pharmaceutical
presentations,
nutraceutical
products,
supplements,
functional
foods.
clinical
evidence
these
molecules
is
increasingly
solid,
among
which
epigallocatechin-3-gallate,
ellagic
acid,
resveratrol,
berberine,
anthocyanins,
probiotics,
carotenoids,
curcumin,
silymarin,
hydroxy
citric
α-lipoic
acid
molecular
mechanisms
signaling
pathways
been
shown
interact
with
endocrine,
nervous,
gastroenteric
systems,
as
well
regulate
expression
multiple
genes
and,
therefore,
proteins
involved
starvation-satiety
processes,
activation
brown
adipose
tissue,
increased
lipolysis,
decreased
lipogenesis,
inflammation,
beneficial
changes
metabolism
improved
insulin
sensitivity.
This
review
provides
comprehensive
view
nature-based
therapeutic
options
address
obesity.
It
offers
valuable
perspective
future
research
subsequent
practice,
addressing
everything
from
molecular,
genetic,
physiological
bases
study
compound.
