Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(14), С. 7933 - 7942
Опубликована: Март 28, 2024
Ethanol
(EtOH)
has
been
identified
as
a
potential
pathogenic
factor
in
gastric
ulcer
development
primarily
due
to
its
association
with
injury
and
excessive
production
of
reactive
oxygen
species.
Magnolol
(Mag),
the
principal
active
compound
Magnolia
officinalis
extract,
is
well
studied
for
notable
anti-inflammatory
antioxidant
properties.
However,
limited
solubility,
propensity
agglomeration,
low
absorption
utilization
rates
significantly
restrict
therapeutic
use.
This
study
aims
overcome
these
challenges
by
developing
Mag
nanoparticle
system
targeting
treatment
prevention
EtOH-induced
ulcers
mice.
Utilizing
click
chemistry
approach,
we
successfully
synthesized
this
reacting
thiolated
bovine
serum
albumin
(BSA·SH)
Mag.
The
vitro
analysis
revealed
effective
uptake
BSA·SH-Mag
human
epithelial
cells
(GES-1),
showcasing
capabilities.
Additionally,
exhibited
gradual
disintegration
release
simulated
fluid,
resulting
reduction
oxidative
stress
tissues
mucosal
tissue
repair
effectively
reducing
inflammatory
expression.
Furthermore,
attenuated
inflammation
decreasing
level
NOX4
protein
expression
augmenting
Nrf2
In
conclusion,
our
findings
indicate
that
represents
promising
candidate
an
oral
treatment.
Archives of Toxicology,
Год журнала:
2023,
Номер
97(10), С. 2499 - 2574
Опубликована: Авг. 19, 2023
Abstract
A
physiological
level
of
oxygen/nitrogen
free
radicals
and
non-radical
reactive
species
(collectively
known
as
ROS/RNS)
is
termed
oxidative
eustress
or
“good
stress”
characterized
by
low
to
mild
levels
oxidants
involved
in
the
regulation
various
biochemical
transformations
such
carboxylation,
hydroxylation,
peroxidation,
modulation
signal
transduction
pathways
Nuclear
factor-κB
(NF-κB),
Mitogen-activated
protein
kinase
(MAPK)
cascade,
phosphoinositide-3-kinase,
nuclear
factor
erythroid
2–related
2
(Nrf2)
other
processes.
Increased
ROS/RNS,
generated
from
both
endogenous
(mitochondria,
NADPH
oxidases)
and/or
exogenous
sources
(radiation,
certain
drugs,
foods,
cigarette
smoking,
pollution)
result
a
harmful
condition
stress
(“bad
stress”).
Although
it
widely
accepted,
that
many
chronic
diseases
are
multifactorial
origin,
they
share
common
denominator.
Here
we
review
importance
mechanisms
through
which
contributes
pathological
states
an
organism.
Attention
focused
on
chemistry
ROS
RNS
(e.g.
superoxide
radical,
hydrogen
peroxide,
hydroxyl
radicals,
peroxyl
nitric
oxide,
peroxynitrite),
their
role
damage
DNA,
proteins,
membrane
lipids.
Quantitative
qualitative
assessment
biomarkers
also
discussed.
Oxidative
pathology
cancer,
cardiovascular
diseases,
diabetes,
neurological
disorders
(Alzheimer’s
Parkinson’s
Down
syndrome),
psychiatric
(depression,
schizophrenia,
bipolar
disorder),
renal
disease,
lung
disease
(chronic
pulmonary
obstruction,
cancer),
aging.
The
concerted
action
antioxidants
ameliorate
effect
achieved
antioxidant
enzymes
(Superoxide
dismutases-SODs,
catalase,
glutathione
peroxidase-GPx),
small
molecular
weight
(vitamins
C
E,
flavonoids,
carotenoids,
melatonin,
ergothioneine,
others).
Perhaps
one
most
effective
vitamin
first
line
defense
against
peroxidation
promising
approach
appears
be
use
flavonoids),
showing
weak
prooxidant
properties
may
boost
cellular
systems
thus
act
preventive
anticancer
agents.
Redox
metal-based
enzyme
mimetic
compounds
potential
pharmaceutical
interventions
sirtuins
therapeutic
targets
for
age-related
anti-aging
strategies
Current Issues in Molecular Biology,
Год журнала:
2023,
Номер
45(8), С. 6651 - 6666
Опубликована: Авг. 12, 2023
Oxidative
stress
is
a
critical
factor
in
the
pathogenesis
and
progression
of
diabetes
its
associated
complications.
The
imbalance
between
reactive
oxygen
species
(ROS)
production
body’s
antioxidant
defence
mechanisms
leads
to
cellular
damage
dysfunction.
In
diabetes,
chronic
hyperglycaemia
mitochondrial
dysfunction
contribute
increased
ROS
production,
further
exacerbating
oxidative
stress.
This
burden
adversely
affects
various
aspects
including
impaired
beta-cell
function
insulin
resistance,
leading
disrupted
glucose
regulation.
Additionally,
stress-induced
blood
vessels
endothelial
development
diabetic
vascular
complications
such
as
retinopathy,
nephropathy,
cardiovascular
diseases.
Moreover,
organs
tissues
throughout
body,
kidneys,
nerves,
eyes,
are
vulnerable
stress,
resulting
neuropathy,
retinopathy.
Strategies
mitigate
include
therapy,
lifestyle
modifications,
effective
management
hyperglycaemia.
However,
research
necessary
comprehensively
understand
underlying
evaluate
efficacy
interventions
preventing
treating
By
addressing
it
might
be
possible
alleviate
improve
patient
outcomes.
Clinical Science,
Год журнала:
2023,
Номер
137(22), С. 1721 - 1751
Опубликована: Ноя. 1, 2023
Abstract
Ageing
is
a
complex
biological
process
associated
with
increased
morbidity
and
mortality.
Nine
classic,
interdependent
hallmarks
of
ageing
have
been
proposed
involving
genetic
biochemical
pathways
that
collectively
influence
trajectories
susceptibility
to
pathology
in
humans.
skeletal
muscle
undergoes
profound
morphological
physiological
changes
loss
strength,
mass,
function,
condition
known
as
sarcopenia.
The
aetiology
sarcopenia
whilst
research
this
area
growing
rapidly,
there
relative
paucity
human
studies,
particularly
older
women.
Here,
we
evaluate
how
the
nine
classic
ageing:
genomic
instability,
telomere
attrition,
epigenetic
alterations,
proteostasis,
deregulated
nutrient
sensing,
mitochondrial
dysfunction,
cellular
senescence,
stem
cell
exhaustion,
altered
intercellular
communication
contribute
pathophysiology
We
also
highlight
five
novel
particular
significance
inflammation,
neural
extracellular
matrix
reduced
vascular
perfusion,
ionic
dyshomeostasis,
discuss
are
interconnected.
Their
clinical
relevance
translational
potential
considered.
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 298 - 298
Опубликована: Фев. 28, 2024
Ferroptosis
is
a
type
of
programmed
cell
death
that
differs
from
apoptosis,
autophagy,
and
necrosis
related
to
several
physio-pathological
processes,
including
tumorigenesis,
neurodegeneration,
senescence,
blood
diseases,
kidney
disorders,
ischemia–reperfusion
injuries.
linked
iron
accumulation,
eliciting
dysfunction
antioxidant
systems,
which
favor
the
production
lipid
peroxides,
membrane
damage,
ultimately,
death.
Thus,
signaling
pathways
evoking
ferroptosis
are
strongly
associated
with
those
protecting
cells
against
excess
and/or
lipid-derived
ROS.
Here,
we
discuss
interaction
between
metabolic
particular
focus
on
transcription
factors
implicated
in
regulation
ferroptosis,
either
as
triggers
peroxidation
or
defense
pathways.
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1109 - 1109
Опубликована: Сен. 13, 2024
Oxidative
stress
is
the
result
of
imbalance
between
reactive
oxygen
and
nitrogen
species
(RONS),
which
are
produced
by
several
endogenous
exogenous
processes,
antioxidant
defenses
consisting
molecules
that
protect
biological
systems
from
free
radical
toxicity.
a
major
factor
in
aging
process,
contributing
to
accumulation
cellular
damage
over
time.
biomolecules,
leads
DNA
alterations,
lipid
peroxidation,
protein
oxidation,
mitochondrial
dysfunction
resulting
senescence,
immune
system
tissue
dysfunctions,
increased
susceptibility
age-related
pathologies,
such
as
inflammatory
disorders,
cardiovascular
neurodegenerative
diseases,
diabetes,
cancer.
stress-driven
mutations,
or
methylation
histone
modification,
alter
gene
expression,
key
determinants
tumor
initiation,
angiogenesis,
metastasis,
therapy
resistance.
Accumulation
genetic
epigenetic
damage,
oxidative
contributes,
eventually
unrestrained
cell
proliferation,
inhibition
differentiation,
evasion
death,
providing
favorable
conditions
for
tumorigenesis.
Colorectal,
breast,
lung,
prostate,
skin
cancers
most
frequent
aging-associated
malignancies,
implicated
their
pathogenesis
behavior.
Our
aim
shed
light
on
molecular
mechanisms
link
stress,
aging,
cancers,
highlighting
impact
both
RONS
antioxidants,
provided
diet
exercise,
immunity,
development
an
antitumor
response.
The
dual
role
ROS
physiological
regulators
signaling
responsible
well
its
use
anti-tumor
therapeutic
purposes,
will
also
be
discussed.
Managing
crucial
promoting
healthy
reducing
risk
tumors.
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Май 22, 2024
Abstract
Replication
stress
refers
to
slowing
or
stalling
of
replication
fork
progression
during
DNA
synthesis
that
disrupts
faithful
copying
the
genome.
While
long
considered
a
nexus
for
damage,
role
in
aging
is
under-appreciated.
The
consequential
promotion
organismal
phenotypes
evidenced
by
an
extensive
list
hereditary
accelerated
disorders
marked
molecular
defects
factors
promote
and
operate
uniquely
response.
Additionally,
recent
studies
have
revealed
cellular
pathways
elicited
align
with
designated
hallmarks
aging.
Here
we
review
advances
demonstrating
as
ultimate
driver
senescence
We
discuss
clinical
implications
intriguing
links
between
including
application
senotherapeutic
approaches
context
stress.
Mitochondrial
DNA
(mtDNA)
copy
number
and
telomere
length
(TL)
are
dynamic
factors
that
have
been
linked
to
the
aging
process
in
organisms.
However,
causal
relationship
between
these
variables
remains
uncertain.
In
this
research,
instrumental
(IVs)
related
mtDNA
TL
were
obtained
from
publicly
available
genome-wide
association
studies
(GWAS).
Through
bidirectional
Mendelian
randomization
(MR)
analysis,
we
examined
potential
factors.
The
forward
with
as
exposure
outcome,
did
not
reveal
a
significant
effect
(
