Sarcopenia

Nature Reviews Disease Primers, Год журнала: 2024, Номер 10(1)

Опубликована: Сен. 19, 2024

Язык: Английский

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The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline

Опубликована: Авг. 12, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.

Язык: Английский

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Age-related and cancer-related sarcopenia: is there a difference?

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2024, Номер 27(5), С. 410 - 418

Опубликована: Март 15, 2024

The aim of this review is the attempt to differentiating pathophysiologic and clinical features aging-related sarcopenia from cancer-related sarcopenia. In fact, there some controversy among experts mainly regarding two points: always sarcopenia, even that one, expression a generalized disease or may exist independently without major alteration muscle function? Are completely separated entities?

Язык: Английский

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Reliability of MyotonPro in measuring the biomechanical properties of the quadriceps femoris muscle in people with different levels and types of motor preparation

Frontiers in Sports and Active Living, Год журнала: 2024, Номер 6

Опубликована: Авг. 29, 2024

The aim of this research was to evaluate the reliability measurements biomechanical parameters muscles athletes representing different disciplines as well untrained people. Ninety-four young, healthy male individuals participated in study and were divided into five subgroups: footballers ( n = 25), volleyballers 14), handballers 19), MMA fighters 16), undrained group 20). All participants underwent stiffness (S), muscle tone (T) elasticity (E) by two independent measurers using MyotonPro equipment. Analysis conducted on parts quadriceps femoris: rectus femoris (RF) vastus medialis (VM. Consequently, comprehensive analysis comprised 564 (94 * 3 282 2 564). results proves high myotonometry (Pearson's CC over 0.8208–0.8871 for parameters, ICC from 0.74 0.99 parameters) excluding only VM which characterized withlow 0.08 relatively highest between examined MAE% 8.7% still remains low value. most significant differences groups observed terms (correlation 0.14842 0.15083 respecitively). These confirm usability measuring properties sports independence obtained person performing measurement.

Язык: Английский

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096

Опубликована: Сен. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Язык: Английский

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Nutrition in the prevention and treatment of skeletal muscle ageing and sarcopenia: a single nutrient, a whole food, and a whole diet approach

Proceedings of The Nutrition Society, Год журнала: 2024, Номер unknown, С. 1 - 16

Опубликована: Окт. 17, 2024

Loss of skeletal muscle strength and mass (sarcopenia) is common in older adults associated with an increased risk disability, frailty premature death. Finding cost-effective prevention treatment strategies for sarcopenia the growing ageing population therefore great public health interest. Although nutrition considered important factor aetiology sarcopenia, its potential and/or still being evaluated. Nutrition research utilises three main approaches to understand muscle-nutrition relationships, evaluating: single nutrients, whole foods diet effects - both alone or combined exercise. Applying these approaches, we summarise recent evidence from qualitative quantitative syntheses findings observational intervention studies healthy adults, those sarcopenia. We consider protein supplements, (fruits vegetables) Mediterranean as exemplars. There some beneficial supplementation ≥ 0·8 g/kg body weight/d on when exercise training sarcopenic adults. In contrast, function (strength physical performance) inconclusive. reasonably consistent epidemiological suggesting benefits higher fruits vegetables consumption better performance. Similarly, adherence studies. However, are lacking. This review discusses how current may inform development preventive optimal nutritional policy aimed at combatting

Язык: Английский

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The velocity of temporalis muscle wasting in cerebral metastasis is prognostic for poor survival

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Фев. 28, 2025

Purpose Recently, the temporalis muscle thickness on cranial CT scan was proposed as a surrogate marker for patients’ baseline frailty that correlates with outcome in primary and metastatic brain tumor patients. In this study, we investigated whether velocity of atrophy (TMA) affects patients cerebral metastases. Methods We analyzed radiological clinical data sets 96 who received craniotomy metastasis resection our institution. then correlated course after stratification atrophy. Results The median TMA 0.0016 mm/day. slow rate, overall survival significantly longer than fast rate (37.7 months versus 22.9, p = 0.0007). Furthermore, had progression-free postoperatively (7.6 4.38 months, <0.0001). (OS-PO) also (8.9 5.1, p=0002). Conclusion Based may represent an objective dynamic index potential prognostication

Язык: Английский

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Effects of aging on calcium channels in skeletal muscle

Frontiers in Molecular Biosciences, Год журнала: 2025, Номер 12

Опубликована: Март 19, 2025

In skeletal muscle, calcium is not only essential to stimulate and sustain their contractions but also for muscle embryogenesis, regeneration, energy production in mitochondria, fusion. Different ion channels contribute achieving the various functions of muscles. Muscle contraction initiated by releasing from sarcoplasmic reticulum through ryanodine receptor gated mechanically four dihydropyridine receptors T-tubules. The influx store-operated sustains stimulates regeneration. Mitochondrial uniporter allows entry into mitochondria oxidative phosphorylation. Aging alters expression activity these different channels, resulting a reduction force generation regeneration capacity. Regular physical training bioactive molecules nutrients can prevent effects aging on channels. This review focuses current knowledge muscles’

Язык: Английский

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Exploring the impact of vitamin D-related genetic variants on muscular fitness changes in middle-aged and older adults in Kosovo

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Фев. 13, 2025

Introduction Age-related decline in muscle strength and performance significantly impact morbidity mortality. Various factors including genetics have been investigated to better understand this decline. This study aimed investigate longitudinal changes physical their association with genetic variants genes involved the vitamin D pathway. Methods was conducted Prishtina region, Kosovo, community-dwelling adults over 40 years of age. Genomic DNA extracted from saliva samples assess single nucleotide polymorphisms receptor (VDR) gene (rs7975232, rs2228570, rs731236, also referred as ApaI, FokI, TaqI, respectively) binding protein (GC) (rs4588, rs2282679). Physical assessed by isometric handgrip strength, 30-s chair stand, timed up go 6-min walk test. Vitamin levels were blood only at follow-up. Results A total 138 participants (65.1 ± 9.0 years, 52.2% female) included. Over a 2.7-year period, significant declines stand test ( p < 0.001) observed, whereas BMI increased. Only female experienced decrease 0.001). Genotyping showed associations ApaI variant strength. Participants minor CC genotype greater increase absolute relative No interactions observed for FokI TaqI VDR gene, or rs4588 rs2282679 GC gene. deficiency (<50 nmol/L) prevalent 47.5% participants, differences 25(OH)D between genotypes = 0.039; rs2282679, 0.036). Conclusion fitness declined time, experiencing The associated while levels. These findings suggest that related pathway may contribute age-related Therefore, predisposition should be considered when developing individual interventions healthy aging.

Язык: Английский

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Sarcopenia and Type 2 Diabetes Mellitus: Evaluation, Pathophysiological Links, and Management Strategies

IntechOpen eBooks, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Sarcopenia refers to the rapid loss of skeletal muscle mass and strength, which can result in serious consequences such as falls, fractures, a higher risk mortality. The prevalence sarcopenia is observed be twice high individuals with type 2 diabetes mellitus. Notably, there bidirectional relationship between mellitus, where each condit‑‑ion exacerbate progression other. Overlapping pathophysiological mechanisms, insulin resistance, inflammation, oxidative stress, accumulation advanced glycation end products, mitochondrial dysfunction, myosteatosis, aging process itself contribute development both conditions. A few treatments, myostatin antagonists, testosterone supplementation, selective androgen receptor modulators have been explored, but many remain experimental or clinical trial stages. cornerstone management involves nutritional intervention foods rich protein, essential amino acids, vitamin D, omega-3 fatty acids. Additionally, incorporating regular physical activity, particularly resistance exercises, minimizing sedentary behavior are key components for sarcopenia.

Язык: Английский

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