Natural Science, Год журнала: 2024, Номер 16(06), С. 102 - 110
Опубликована: Янв. 1, 2024
Язык: Английский
Journal of Pineal Research, Год журнала: 2025, Номер 77(1)
Опубликована: Янв. 1, 2025
Circadian rhythm disruption (CRD), stemming from sleep disorders and/or shift work, is a risk factor for reproductive dysfunction. CRD has been reported to disturb nocturnal melatonin signaling, which plays crucial role in female reproduction as circadian regulator and an antioxidant. The hypothalamic-pituitary-ovarian (HPO) axis regulates reproduction, with luteinizing hormone (LH) pulse pattern playing pivotal folliculogenesis steroidogenesis. However, the effect of on HPO involvement remains unclear. Female CBA/CaJ mice underwent modeling, involves alternating between standard light conditions 8-h advance schedule every 3 days 8 weeks, whereas control were maintained under 12:12-h light/dark (LD) cycle. Subsequent measurements diurnal levels, LH patterns assessments via serial tail-tip blood sampling evaluations ovarian function conducted. altered rhythms wheel-running activity secretion led augmented pattern, evidenced by increased frequency, mean pituitary beta-subunit (LHβ) expression, irregular estrous cycles, abnormal luteal function, endocrine oxidative stress. Melatonin treatment (10 mg/kg/day 4 weeks) significantly improved disorder mice, decreasing enhanced frequency LHβ expression. These findings further validated using vitro LβT2 cell perfusion model. Furthermore, restored scavenged reactive oxygen species, thereby preventing apoptosis preserving function. This study offers new insights into impact emphasizes potential supplementation mitigating its effects reproduction.
Язык: Английский
Процитировано
2
Pharmacological Research, Год журнала: 2024, Номер 204, С. 107213 - 107213
Опубликована: Май 13, 2024
Prostate cancer (PC) and Ovarian (OC) are two of the most common types that affect reproductive systems older men women. These cancers associated with a poor quality life among aged population. Therefore, finding new innovative ways to detect, treat, prevent these in patients is essential. Finding biomarkers for malignancies will increase chance early detection effective treatment, subsequently improving survival rate. Studies have shown prevalence health some illnesses linked an impaired immune system. However, age-associated changes system during such as PC OC poorly understood. Recent research has suggested excessive production inflammatory mediators, interleukin-6 (IL-6), interleukin-8 (IL-8), transforming growth factor (TGF), tumor necrosis (TNF), CXC motif chemokine ligand 1 (CXCL1), 12 (CXCL12), 13 (CXCL13), etc., significantly impact development elderly patients. Our review focuses on latest functional studies pro-inflammatory cytokines (interleukins) chemokines, which serve OC. Thus, we aim shed light how We also examine current status future perspective chemokines-based therapeutic targets treatment
Язык: Английский
Процитировано
11
Journal of Ovarian Research, Год журнала: 2024, Номер 17(1)
Опубликована: Май 31, 2024
Abstract In women who are getting older, the quantity and quality of their follicles or oocytes decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, lower oocytes. As more choose to delay childbirth, decline in fertility associated with age has become a significant concern for modern women. The oocyte key indicator aging. Many studies suggest that age-related changes energy metabolism may impact quality. Changes affect adenosine 5'-triphosphate (ATP) production, but how related products proteins influence remains largely unknown. review focuses on aging its potential quality, as well therapeutic strategies partially metabolism. research aims enhance our understanding metabolism, identification biomarkers treatment methods.
Язык: Английский
Процитировано
10
Reproductive Toxicology, Год журнала: 2024, Номер 124, С. 108534 - 108534
Опубликована: Янв. 6, 2024
Язык: Английский
Процитировано
9
Life Sciences, Год журнала: 2024, Номер 344, С. 122557 - 122557
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
5
Cells, Год журнала: 2024, Номер 13(16), С. 1354 - 1354
Опубликована: Авг. 14, 2024
Autophagy, an evolutionarily conserved cellular mechanism essential for maintaining internal stability, plays a crucial function in female reproductive ability. In this review, we discuss the complex interplay between autophagy and several facets of health, encompassing pregnancy, ovarian functions, gynecologic malignancies, endometriosis, infertility. Existing research emphasizes significance embryo implantation, specifically endometrium, highlighting its necessity ensuring proper fetal development. Although some knowledge has been gained, there is still lack on specific molecular impacts quality oocytes, growth follicles, general health. Autophagy role maturation, quality, development oocytes. It also involved aging, contributing to reductions that occur with age. This review explores physiological functions system, participation toxicity, important connections endometrium embryo. addition, study investigates possibility emerging treatment approaches aim modify autophagy, using both natural substances synthetic molecules, improve fertility outcomes. Additionally, intends inspire future exploration into intricate health by reviewing recent studies pinpointing areas where current lacking. Subsequent investigations should prioritize conversion these discoveries practical uses medical field, which could potentially result groundbreaking therapies infertility other difficulties related reproduction. Therefore, gaining comprehensive understanding many effects would not only further field biology but open new possibilities diagnostic methods.
Язык: Английский
Процитировано
5
Aging, Год журнала: 2024, Номер unknown
Опубликована: Янв. 10, 2024
Premature ovarian insufficiency (POI) is a diverse form of female infertility characterized by decline in function before the age 40. Melatonin (MT) potential clinical treatment for restoring or safeguarding POI. However, specific therapeutic mechanism underlying this effect remains unclear. To address this, we conducted experiments using human granulosa cells (GCs) from both POI and normal patients. We examined expression levels autophagy-related genes proteins GCs through qRT-PCR western blot analysis. Autophagy flux was monitored infected with GFP-LC3-adenovirus, regulatory MT autophagy investigated. Additionally, employed pharmacological intervention 3-Methyladenine (3-MA) RNA interference Forkhead box O-3A (FOXO3A) to elucidate process. Compared patients, patients exhibited irregular morphology, decreased proliferation, increased apoptosis, elevated ROS levels. The downregulated GCs, resulting reduced autophagic activity. Furthermore, were but exogenous effectively activated autophagy. Mechanistically, melatonin FOXO3A induced phosphorylation GCs. Importantly, silencing abolished protective on These findings indicate that accompanied deficiency MT. Moreover, demonstrated supplementing can rescue enhance GC viability activation signaling. Thus, MT-FOXO3A may serve as target treatment.
Язык: Английский
Процитировано
4
Redox Biology, Год журнала: 2025, Номер 80, С. 103510 - 103510
Опубликована: Янв. 22, 2025
Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes protein posttranslational modifications. However, the role of palmitoylation oocyte has not been investigated. In present study, new association between redox oocytes was found. We found that level palmitoyl-protein thioesterase 1 (PPT1), depalmitoylation enzyme, maternally aged mice follicular fluid (age >35 years) patients with decreased ovarian reserve (DOR). Elevated PPT1 led S-palmitoylation oocytes, which impaired maturation spindle formation. Tubulin identified as critical palmitoylated regulated PPT1, whose also advanced age, abnormalities membrane localization microtubule polymerization. Melatonin down-regulate excessive rescue PPT1-induced damage mouse only regulating oxidative stress, but binding regulate its lysosomal degradation. summary, our data demonstrate participates tubulin palmitoylation, providing evidence stress regulates revealing novel mechanism aging.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142181 - 142181
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Endocrines, Год журнала: 2025, Номер 6(2), С. 18 - 18
Опубликована: Апрель 8, 2025
Background: This paper briefly reviews the most important endocrine features of primary ovarian insufficiency (POI) and shows their relevance for diagnosis treatment this condition. Introduction: Endocrine disturbances in POI cause problems both fertility general health status affected women. Both subfertility infertility result from depletion growing follicles which, its turn, is causative factor hypoestrogenism; responsible affecting Method: Search literature. Results conclusion: A combination high-serum follicle-stimulating hormone (FSH) low 17β-estradiol (E2) concentrations a key feature characterizing decisive element diagnosis. However, an in-depth search possible genetic non-genetic causes adequate counseling regarding prevention early intervention. The problems, based on correcting hypoestrogenism through replacement therapy (HRT), relatively easy. On other hand, resolving much more difficult task, oocyte donation only really efficient instrument. Fertility preservation suitable alternative patients with diagnosis, whom some viable are still present ovaries. In who refuse donation, intraovarian injection autologous platelet-rich plasma vitro activation dormant may be considered. Other innovative treatments, such as stem cell therapies or nuclear transfer, currently under investigation.
Язык: Английский
Процитировано
0