Effect of Size, Shape and Surface Functionalization on the Antibacterial Activity of Silver Nanoparticles

Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(5), С. 244 - 244

Опубликована: Апрель 26, 2023

Silver nanoparticles (AgNPs) are the most investigated antibacterial agents against multidrug resistant (MDR) pathogens. They can lead to cellular death by means of different mechanisms, damaging several cell compartments, from external membrane, enzymes, DNA and proteins; this simultaneous attack amplifies toxic effect on bacteria with respect traditional antibiotics. The effectiveness AgNPs MDR is strongly correlated their chemical morphological properties, which influence pathways involved in damage. In review, AgNPs’ size, shape modification functional groups or other materials reported, both investigate synthetic nanoparticles’ modifications evaluate related activity. Indeed, understanding conditions for obtaining performing could help tailor new improved silver-based combat resistance.

Язык: Английский

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Polydopamine Nanosystems in Drug Delivery: Effect of Size, Morphology, and Surface Charge

Nanomaterials, Год журнала: 2024, Номер 14(3), С. 303 - 303

Опубликована: Фев. 1, 2024

Recently, drug delivery strategies based on nanomaterials have attracted a lot of interest in different kinds therapies because their superior properties. Polydopamine (PDA), one the most interesting materials nanomedicine its versatility and biocompatibility, has been widely investigated field. It can be easily functionalized to favor processes like cellular uptake blood circulation, it also induce release through two stimuli: NIR light irradiation pH. In this review, we describe PDA nanomaterials’ performance delivery, size, morphology, surface charge. Indeed, these characteristics strongly influence main mechanisms involved system: uptake, loading, release. The understanding connections between nanosystems’ properties phenomena is pivotal obtain controlled design new nanocarriers specific applications.

Язык: Английский

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Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review

Heliyon, Год журнала: 2024, Номер 10(2), С. e24207 - e24207

Опубликована: Янв. 1, 2024

High blood glucose levels are a hallmark of the metabolic syndrome known as diabetes mellitus. More than 600 million people will have by 2045 global prevalence disease continues to rise. Contemporary antidiabetic drugs reduce hyperglycemia and its consequences. However, these come with undesirable side effects, so it's encouraging that research into plant extracts bioactive substances characteristics is on Natural remedies preferable conventional anti-diabetic since they safer for body, more affordable fewer potential adverse effects. Biological macromolecules such liposomes, niosomes, polymeric nanoparticles, solid lipid nanoemulsions metallic nanoparticles explored in this review. Current drug restrictions been addressed, effectiveness plant-based therapies has enhanced merits methods. Plant extracts' loading capacity carriers' stability primary obstacles developing nanocarriers. Hydrophilic, hydrophobic, amphiphilic covered, brief overview amphipathic features phospholipids, nanocarriers provided. Metallic nanoparticles' benefits attendant risks highlighted emphasize their efficiency treating hyperglycemia. Researchers interested loaded therapeutics may find current helpful

Язык: Английский

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Melanin from Pecan Nut Shell Waste as an Antioxidant and Antifungal Additive in Membranes for Food Packaging

Journal of Polymers and the Environment, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Язык: Английский

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Engineered Macrophage Membrane-Coated Nanoparticles Attenuate Calcium Oxalate Nephrocalcinosis-Induced Kidney Injury by Reducing Oxidative Stress and Pyroptosis

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Nanodrug Delivery Systems for Myasthenia Gravis: Advances and Perspectives

Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 651 - 651

Опубликована: Май 11, 2024

Myasthenia gravis (MG) is a rare chronic autoimmune disease caused by the production of autoantibodies against postsynaptic membrane receptors present at neuromuscular junction. This condition characterized fatigue and muscle weakness, including diplopia, ptosis, systemic impairment. Emerging evidence suggests that in addition to immune dysregulation, pathogenesis MG may involve mitochondrial damage ferroptosis. Mitochondria are primary site energy production, reactive oxygen species (ROS) generated due dysfunction can induce Nanomedicines have been extensively employed treat various disorders their modifiability good biocompatibility, but application management has rather limited. Nevertheless, nanodrug delivery systems carry immunomodulatory agents, anti-oxidants, or ferroptosis inhibitors could be effective for treatment MG. Therefore, this review focuses on nanoplatforms aimed attenuating restoring function, inhibiting potentially serve as promising agents targeted therapy.

Язык: Английский

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Melanin for Photoprotection and Hair Coloration in the Emerging Era of Nanocosmetics

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5862 - 5862

Опубликована: Май 28, 2024

Nanotechnology is revolutionizing fields of high social and economic impact. such as human health preservation, energy conversion storage, environmental decontamination, art restoration. However, the possible global-scale application nanomaterials raising increasing concerns, mostly related to toxicity materials at nanoscale. The possibility using in cosmetics, hence products aimed be applied directly body, even just externally, strongly debated. Preoccupation arises especially from consideration that are synthetic origin, often seen "artificial" their effects unpredictable. Melanin, this framework, a unique material since nature it plays important roles specific cosmetics cover, photoprotection hair skin coloration. Moreover, melanin present form nanoparticles, clearly observable ink some animals, like cuttlefish. artificial nanoparticles share same biocompatibility natural ones chemical photochemical properties. Melanin nanocosmetic agent, but its actual still under development, also because regulatory issues. Here, we critically discuss most recent examples biomimetic highlight requirements future steps would improve melanin-based view applications everyday market.

Язык: Английский

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Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (Carya illinoinensis) Residues for Skin-Care Applications

Membranes, Год журнала: 2025, Номер 15(2), С. 44 - 44

Опубликована: Фев. 3, 2025

This study investigates the incorporation of melanin extracted from pecan nutshell residues into a polyacrylonitrile (PAN) matrix during electrospinning microfiber membranes. Melanin concentrations 0.5, 2.0, and 5.0% w/w were incorporated to enhance physicochemical biological properties fibers. The melanin-loaded PAN fibers exhibited significant antioxidant activity against DPPH ABTS radicals, with scavenging rates ranging 46.58% 62.77% 41.02% 82.36%, respectively, while unmodified showed no activity. Furthermore, membranes demonstrated antimicrobial effects. also an important enzyme inhibition collagenase (37%), hyaluronidase (22%), tyrosinase (36%), elastase (33%). Molecular docking studies reveal different potential amino acids active sites aging enzymes that interact strongly pigment, particularly collagenase, followed by hyaluronidase, tyrosinase, elastase. These results suggest novel possess promising bioactive applications in skin-care applications.

Язык: Английский

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Photochemical Pathways and Light-Enhanced Radical Scavenging Activity of 1,8-Dihydroxynaphthalene Allomelanin

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Melanins play important roles in nature, particularly coloration and photoprotection, where interaction with light is essential. Biomimetic melanins represent an advantageous alternative to natural melanin for technological applications, sharing the same unique biocompatibility, as well optoelectronic properties. Allomelanin, derived from 1,8-dihydroxynaphthalene, has been reported exhibit even better photoprotective antioxidant properties than most studied example of biomimetic melanin, polydopamine. However, allomelanin remains largely unexplored. Here we report excited state dynamics a wide range time windows femtoseconds microseconds minutes, using different experimental techniques, i.e., ultrafast transient absorption, nanosecond X-band electron paramagnetic resonance radical quenching assays. We find that photophysics starkly differs widely polydopamine, broadband excitonically coupled states funneling absorbed energy lower species less 1 ps. Independent excitation wavelength, long-lived (>450 μs) photoproduct populated ≈24 Quantum chemistry calculations suggest primarily exhibits character localized 1,8-naphthoquinone anions. This light-driven increase anionic semiquinone-like concentration enhances activity allomelanin. These results two mechanisms considered at basis light-extinction action, are indeed synergistic not independent, paving way new applications nanomedicine, photocatalysis, conversion environmental remediation.

Язык: Английский

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Melanin-like nanoparticles alleviate ischemia-reperfusion injury in the kidney by scavenging reactive oxygen species and inhibiting ferroptosis

iScience, Год журнала: 2024, Номер 27(4), С. 109504 - 109504

Опубликована: Март 14, 2024

Highlights•PPR NPs were ∼100 nm spherical particles with good ROS scavenging ability•PPR could enter renal tubular cells and then release rutin to eliminate ROS•PPR alleviate IRI damage by repairing mitochondria suppressing ferroptosisSummaryKidney transplantation is essential for patients end-stage disease; however, ischemia-reperfusion injury (IRI) during can lead acute kidney compromise survival. Recent studies have reported that antiferroptotic agents may be a potential therapeutic strategy, reducing production of reactive oxygen species (ROS). Therefore, we constructed rutin-loaded polydopamine nanoparticles (PEG-PDA@rutin NPs, referred as PPR NPs) resulting from IRI. Physicochemical characterization showed the ability. Notably, effectively lipopolysaccharide (LPS)-treated cells, (PDA) released ROS, repair mitochondria, suppress ferroptosis. Furthermore, in vivo imaging revealed efficiently accumulated kidneys after protected against damage. In conclusion, demonstrated an excellent ability ferroptosis, protect IRI.Graphical abstract

Язык: Английский

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