PubMed,
Год журнала:
2024,
Номер
26(2), С. 201 - 206
Опубликована: Фев. 15, 2024
Attention
deficit
hyperactivity
disorder
(ADHD)
is
a
common
neurodevelopmental
in
children
and
adolescents,
its
etiology
pathogenesis
are
still
unclear.
Brain
the
organ
with
largest
oxygen
consumption
human
body
easily
affected
by
oxidative
imbalance.
Oxidative
stress
has
become
key
research
direction
for
of
ADHD,
but
there
lack
relevant
studies
China.
Based
on
latest
findings
China
overseas,
this
article
reviews
clinical
experimental
ADHD
explores
association
neurotransmitter
imbalance,
neuroinflammation,
cell
apoptosis
so
as
to
provide
new
ideas
exploring
ADHD.
International Journal of Health Science,
Год журнала:
2024,
Номер
4(16), С. 2 - 10
Опубликована: Фев. 7, 2024
The
development
of
neurodegenerative
diseases
is
strongly
related
to
oxidative
stress,
due
an
imbalance
in
cellular
metabolism.There
are
currently
different
therapies
available
treat
these
diseases,
although
they
often
not
curative
and/or
have
adverse
effects.In
view
the
above,
it
necessary
find
complementary
alternative
medicines
that
replace
current
treatments,
showing
fewer
side
effects.Secondary
metabolites
synthesized
by
invasive
plants,
specifically
phenolic
compounds,
a
great
capacity
suppress
neutralizing
free
radicals.Thus,
compounds
can
be
used
as
pharmacological
treatments
for
pathological
conditions
associated
with
increased
stress.Currently,
species
considered
one
greatest
threats
preservation
biodiversity
world,
causing
negative
impacts
at
both
environmental
and
socioeconomic
level.Therefore,
imperative
measures
implemented
control
manage
them,
ensuring
balanced
ecosystem
and,
same
time,
promoting
sustainable
economy.The
use
extraction
bioactive
from
plants
possible
applications
field
medicine
futuristic
strategy,
aiming
implement
2030
Agenda
some
objectives.
Seven Editora eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 22, 2024
Parkinson's
disease
(PD)
is
characterized
by
the
progressive
degeneration
of
dopaminergic
neurons
substantia
nigra,
leading
to
motor
changes
that
progress
tremors,
rigidity
and
bradykinesia
with
postural
instability.
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Май 1, 2024
Abstract
Glial
cells
constitute
nearly
half
of
the
mammalian
nervous
system's
cellular
composition.
The
glia
in
C.
elegans
perform
majority
tasks
comparable
to
those
conducted
by
their
equivalents.
cephalic
sheath
(CEPsh)
glia,
which
are
known
be
counterparts
astrocytes,
enriched
with
two
nuclear
hormone
receptors
(NHRs)—NHR-210
and
NHR-231.
This
unique
enrichment
makes
CEPsh
these
NHRs
intriguing
subjects
study
concerning
neuronal
health.
We
endeavored
assess
role
neurodegenerative
diseases
related
functional
processes,
using
transgenic
expressing
human
alpha-synuclein.
employed
RNAi-mediated
silencing,
followed
behavioural,
functional,
metabolic
profiling
relation
suppression
NHR-210
231.
Our
findings
revealed
that
depleting
nhr-210
changes
dopamine-associated
behaviour
mitochondrial
function
alpha
synuclein-expressing
strains
NL5901
UA44,
through
a
putative
target,
pgp-9
,
transmembrane
transporter.
Considering
alteration
involvement
transporter,
we
performed
metabolomics
via
HR-MAS
NMR
spectroscopy.
Remarkably,
substantial
modifications
ATP,
betaine,
lactate,
glycine
levels
were
seen
upon
absence
.
also
detected
considerable
pathways
such
as
phenylalanine,
tyrosine,
tryptophan
biosynthesis
metabolism;
glycine,
serine,
threonine
well
glyoxalate
dicarboxylate
metabolism.
In
conclusion,
deficiency
receptor
alpha-synuclein
strain
results
altered
function,
coupled
alterations
vital
metabolite
levels.
These
underline
physiological
importance
glia.
Graphical
abstract
Antioxidants,
Год журнала:
2023,
Номер
12(12), С. 2045 - 2045
Опубликована: Ноя. 26, 2023
Several
studies
showed
an
association
between
metabolic
syndrome
(MetS)
and
Parkinson's
disease
(PD).
The
linking
mechanisms
remain
unclear.
MetS
promotes
low-grade
peripheral
oxidative
stress
inflammation
dysregulation
of
the
adipose
renin-angiotensin
system
(RAS).
Interestingly,
brain
RAS
is
involved
in
progression
dopaminergic
degeneration
PD.
Circulating
extracellular
vesicles
(EVs)
from
fat
tissue
can
cross
brain-blood
barrier
may
act
as
signals.
We
isolated
characterized
EVs
control
rats
analyzed
their
mRNA
protein
cargo
using
RT-PCR
ExoView
R200
platform,
respectively.
Furthermore,
cultures
N27
cell
line
C6
astrocytic
were
treated
with
rats.
highly
increased
rat
serum,
which
was
inhibited
by
treatment
angiotensin
type-1-receptor
blocker
candesartan.
pro-oxidative/pro-inflammatory
decreased
anti-oxidative/anti-inflammatory
components,
candesartan-treated
In
cultures,
death
modulated
function,
upregulating
markers
neuroinflammation
stress,
pre-treatment
results
models
suggest
a
mechanism
Mets
PubMed,
Год журнала:
2024,
Номер
26(2), С. 201 - 206
Опубликована: Фев. 15, 2024
Attention
deficit
hyperactivity
disorder
(ADHD)
is
a
common
neurodevelopmental
in
children
and
adolescents,
its
etiology
pathogenesis
are
still
unclear.
Brain
the
organ
with
largest
oxygen
consumption
human
body
easily
affected
by
oxidative
imbalance.
Oxidative
stress
has
become
key
research
direction
for
of
ADHD,
but
there
lack
relevant
studies
China.
Based
on
latest
findings
China
overseas,
this
article
reviews
clinical
experimental
ADHD
explores
association
neurotransmitter
imbalance,
neuroinflammation,
cell
apoptosis
so
as
to
provide
new
ideas
exploring
ADHD.
