Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 20, 2024
Introduction:
Aged-related
brain
damage
and
gut
microbiome
disruption
are
common.
Research
affirms
that
modulating
the
microbiota-gut-brain
axis
can
help
reduce
age-related
damage.
Methods:
Ginseng,
esteemed
in
traditional
Chinese
medicine,
is
recognized
for
its
anti-aging
capabilities.
However,
previous
Ginseng
studies
have
largely
focused
on
diseased
animal
models.
To
this
end,
efforts
were
hereby
made
to
explore
potential
neuroprotective
effects
of
fecal
microbiota
transplantation
(FMT)
from
Ginseng-supplemented
aged
mice
those
pre-treated
with
antibiotics.
Results:
As
a
result,
FMT
specific
modifications
natural
aging
improved
weight
gain,
extended
telomere
length,
anti-oxidative
stress
tissue,
regulated
serum
levels
cytokine,
balanced
proportion
Treg
cells.
Besides,
increased
abundance
beneficial
bacteria
Lachnospiraceae
,
Dubosiella
Bacteroides
etc.
decreased
pathogenic
Helicobacter
Lachnoclostridium
samples
mice.
This
revealed
remarkably
reshaped
microbiome.
Additionally,
FMT-treated
showed
metabolites
Ursolic
acid,
β-carotene,
S-Adenosylmethionine,
Spermidine,
Guanosine,
Celecoxib,
Linoleic
etc.,
which
significantly
positively
correlated
critical
above.
these
identified
mainly
enriched
pathways
Amino
acid
metabolism,
Lipid
Nucleotide
Furthermore,
downregulated
p53/p21/Rb
signaling
upregulated
p16/p14,
ATM/synapsin
I/synaptophysin/PSD95,
CREB/ERK/AKT
following
aging.
Discussion:
Overall,
study
demonstrates
reprogramming
by
impedes
process,
possibly
through
regulation
axis.
Язык: Английский
Vitamin E: An assistant for black soldier fly to reduce cadmium accumulation and toxicity
Environment International,
Год журнала:
2024,
Номер
185, С. 108547 - 108547
Опубликована: Март 1, 2024
Cadmium
(Cd)
is
a
toxic
heavy
metal
associated
with
osteoporosis,
liver,
and
kidney
disease.
The
black
solder
fly
(BSF)
Hermetia
illucens
may
be
exposed
to
Cd
during
the
transformation
of
livestock
manure.
BSF
has
high
tolerance
Cd.
In
previous
work
laboratory,
we
found
that
vitamin
E
(VE)
play
role
in
exposure.
main
findings
are
as
follows:
larvae
pretreated
exogenous
VE
had
heavier
body
weight,
lower
content
toxicity
under
similar
Even
exposure
at
concentrations
300
700
mg/kg
concentration
100
still
reduced
85.33
%
84.43
%,
respectively.
best-fitting
models
showed
metallothionein
(MT)
content,
oxidative
damage
(8-hydroxydeoxyguanosine
malondialdehyde
content),
antioxidant
power
(total
power,
peroxidase
activity)
great
influence
on
bioaccumulated
larvae.
degree
was
pretreatments.
This
variation
can
explained
by
their
changed
MT
increased
because
VE.
These
results
reveal
roles
insects
defense
against
provide
new
option
for
prevention
therapy
caused
Язык: Английский
Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E
Опубликована: Июнь 10, 2024
SARS-CoV-2
is
an
obligatory
intracellular
pathogen
that
requires
of
a
lipid
bilayer
membrane
for
its
transport,
to
build
nucleocapsid
envelope
and
fuse
with
the
host
cell.
The
biological
membranes
are
constituted
by
phospholipids
(PLs)
vitamin
E
(Vit
E)
protects
them
from
oxidative
stress
(OS).
aim
this
study
was
demonstrate
if
treatment
Vit
restores
modified
profile
FA
in
PLs
serum
patients
coronavirus
disease-19
(COVID-19).
We
evaluated
E,
total
fatty
acids
(TFA),
acid
(FAPL),
(TPLs),
8-isoprostane,
thromboxane
B2
(TXB2),
prostaglandins
(PGE2
6-keto-PGF1α),
interleukin-6
(IL-6)
C-reactive
protein
(CRP)
22
COVID-19
before
after
compared
values
those
23
healthy
subjects
(HS).
showed
decrease
TPLs,
FAPL
TFA
comparison
HS
(p≤0.01)
restored
their
levels
(p≤0.04).
Likewise,
there
increase
IL-6
CRP
(p≤0.001)
decreased
(p≤0.001).
Treatment
contributes
restore
infection
leads
OS
inflammatory
process.
Язык: Английский
Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(23), С. 17018 - 17018
Опубликована: Ноя. 30, 2023
Sarcopenia
poses
a
significant
challenge
to
public
health
and
can
severely
impact
the
quality
of
life
aging
populations.
Despite
extensive
efforts
study
muscle
degeneration
using
traditional
animal
models,
there
is
still
lack
effective
diagnostic
tools,
precise
biomarkers,
treatments
for
sarcopenia.
Zebrafish
models
have
emerged
as
powerful
tools
in
biomedical
research,
providing
unique
insights
into
age-related
disorders
like
The
advantages
zebrafish
include
their
rapid
growth
outside
embryo,
optical
transparency
during
early
developmental
stages,
high
reproductive
potential,
ease
husbandry,
compact
size,
genetic
tractability.
By
deepening
our
understanding
molecular
processes
underlying
sarcopenia,
we
may
develop
novel
that
improve
lives
individuals
affected
by
this
condition.
This
review
aims
explore
model
sarcopenia
highlight
recent
breakthroughs,
outline
potential
avenues
future
investigations,
emphasize
distinctive
contributions
offer.
Our
research
endeavors
contribute
significantly
address
urgent
need
practical
solutions
reduce
on
populations,
ultimately
striving
enhance
Язык: Английский
Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions
Опубликована: Сен. 26, 2023
Abstract:
Sarcopenia
poses
a
significant
challenge
to
public
health
and
can
severely
impact
the
quality
of
life
aging
populations.
Despite
extensive
efforts
study
muscle
degeneration
using
traditional
animal
models,
there
is
still
lack
effective
diagnostic
tools,
precise
biomarkers,
treatments
for
sarcopenia.
Zebrafish
models
have
emerged
as
powerful
tools
in
biomedical
research,
providing
unique
insights
into
age-related
disorders
like
The
advantages
zebrafish
include
their
rapid
growth
outside
embryo,
optical
transparency
during
early
developmental
stages,
high
reproductive
potential,
ease
husbandry,
compact
size,
genetic
tractability.
By
deepening
our
understanding
molecular
processes
underlying
sarcopenia,
we
may
develop
novel
that
improve
lives
individuals
affected
by
this
condition.
This
review
aims
explore
model
sarcopenia
highlight
recent
breakthroughs,
outline
potential
avenues
future
investigations,
emphasize
distinctive
contributions
offer.
Our
research
endeavors
contribute
significantly
addressing
urgent
need
practical
solutions
on
populations,
ultimately
striving
enhance
Язык: Английский
Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(7), С. 7219 - 7238
Опубликована: Июль 8, 2024
SARS-CoV-2
is
an
obligatory
intracellular
pathogen
that
requires
a
lipid
bilayer
membrane
for
its
transport
to
build
nucleocapsid
envelope
and
fuse
with
the
host
cell.
The
biological
membranes
are
constituted
by
phospholipids
(PLs),
vitamin
E
(Vit
E)
protects
them
from
oxidative
stress
(OS).
aim
of
this
study
was
demonstrate
if
treatment
Vit
restores
modified
profile
FA
in
PLs
serum
patients
coronavirus
disease-19
(COVID-19).
We
evaluated
E,
total
fatty
acids
(TFAs),
(FAPLs),
(TPLs),
8-isoprostane,
thromboxane
B
Язык: Английский
Modeling Musculoskeletal Disorders in Zebrafish: Advancements in Muscle and Bone Research
Cells,
Год журнала:
2024,
Номер
14(1), С. 28 - 28
Опубликована: Дек. 30, 2024
Zebrafish
(Danio
rerio)
have
emerged
as
a
valuable
model
organism
for
investigating
musculoskeletal
development
and
the
pathophysiology
of
associated
diseases.
Key
genes
biological
processes
in
zebrafish
that
closely
mirror
those
humans,
rapid
development,
transparent
embryos
make
ideal
vivo
studies
bone
muscle
formation,
well
molecular
mechanisms
underlying
disorders.
This
review
focuses
on
utility
modeling
various
conditions,
with
an
emphasis
diseases
such
osteoporosis
osteogenesis
imperfecta,
disorders
like
Duchenne
muscular
dystrophy.
These
models
provided
significant
insights
into
pathways
involved
these
diseases,
helping
to
identify
key
genetic
biochemical
factors
contribute
their
progression.
findings
also
advanced
our
understanding
disease
facilitated
potential
therapeutic
strategies
Язык: Английский