The effects of Mineral Waters from Slănic Moldova's Spring 1 and Spring 1 bis on Fibroblast activity: An In Vitro Study DOI Creative Commons
Constantin Munteanu,

Mihail Hoteteu,

Diana Munteanu

и другие.

Balneo and PRM Research Journal, Год журнала: 2023, Номер Vol.14, no.3, С. 591 - 591

Опубликована: Сен. 1, 2023

Primary fibroblast cultures obtained from Wistar rats were investigated with a focus on two vital physiological mechanisms: inflammatory processes and oxidative stress balance. These are believed to be affected by mud sulfurous natural mineral waters, forming the fundamental biological basis for understanding therapeutic effects of these substances. Existing scientific research highlights that various cell types, including fibroblasts, recruited during inflammation. cells respond wide array intercellular microenvironmental signals, leading regulated production both pro- anti-inflammatory mediators. Examples include cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, well chemokines enzymes like cyclooxygenase (COX)-2. Together, play roles in modulating response.

Язык: Английский

Linkage of circadian rhythm disruptions with Alzheimer’s disease and therapeutic interventions DOI Creative Commons
Kishore Madhamanchi, Jianhua Zhang, Girish C. Melkani

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Identification and Characterization of Two Novel Members of the Family Eubacteriaceae, Anaerofustis butyriciformans sp. nov. and Pseudoramibacter faecis sp. nov., Isolated from Human Feces DOI Creative Commons
Xiaomeng Wang, Haojie Huang,

Xin‐Wei Sun

и другие.

Microorganisms, Год журнала: 2025, Номер 13(4), С. 916 - 916

Опубликована: Апрель 16, 2025

Members of Eubacteriaceae are involved in host health and diseases. Two Gram-stain-positive, strictly anaerobic, non-motile, non-spore-forming, rod-shaped bacterial strains, HA2171T HA2172T, were isolated from the feces Chinese healthy donors. Based on 16S rRNA gene sequences, HA2172T belonged to family Eubacteriaceae. Physiological biochemical characterizations indicated that neutrophilic, mesophilic, tolerant low-concentration NaCl. The major cellular fatty acids (>10.0%) C16:0, C14:0, C18:1ω7c, C17:0 2-OH, those C14:0 C16:0. MK-6 was respiratory quinone both strains. Phylogenetic phylogenomic analyses showed closest Anaerofustis stercorihominis ATCC BAA-858T as Pseudoramibacter alactolyticus 23263T. Genome annotation revealed able metabolize carbohydrates produce acetate butyrate. contains genes associated with hydrogen sulfide production, which is a potential risk for phylogenetic, phenotypic, chemotaxonomic characteristics, we propose represent two novel species, names butyriciformans sp. nov. faecis proposed.

Язык: Английский

Процитировано

0

Dietary Interventions and Oral Nutritional Supplementation in Inflammatory Bowel Disease: Current Evidence and Future Directions DOI Open Access
Brigida Barberio, Luisa Bertin, Sonia Facchin

и другие.

Nutrients, Год журнала: 2025, Номер 17(11), С. 1879 - 1879

Опубликована: Май 30, 2025

Background: Nutritional management has become an integral part of Inflammatory Bowel Disease (IBD) care, with growing evidence supporting specific dietary interventions alongside pharmacologic therapy. However, clinical guidance remains fragmented due to heterogeneous study designs and variable endpoints. Objectives: This review critically examines the current on strategies oral nutritional supplementation (ONS) in both Crohn’s (CD) Ulcerative Colitis (UC), highlighting their applications, mechanisms action, limitations. Methods: A comprehensive literature search was conducted using PubMed, Scopus, Web Science databases, analyzing studies various approaches ONS IBD. Results: Exclusive Enteral Nutrition (EEN) is a first-line therapy pediatric CD, while partial enteral nutrition (PEN) Exclusion Diet (CDED) show promising efficacy better adherence children adults. Whole-food-based interventions, including Mediterranean Diet, Specific Carbohydrate plant-based diets, emerging such as CD-TREAT Tasty & Healthy diet, have demonstrated varying levels benefit disease maintenance symptom control. Targeted exclusion diets—such low-FODMAP, low-emulsifier, low-sulfur diets—may relieve functional symptoms influence inflammatory activity, although preliminary. plays pivotal role addressing malnutrition improving outcomes perioperative hospitalized patients. Conclusions: Dietary represent valuable therapeutic tools IBD management. Future research should prioritize standardized, well-powered trials personalized define within integrated care pathways.

Язык: Английский

Процитировано

0

Exploring Dietary- and Disease-Related Influences on Flatulence and Fecal Odor Perception in Inflammatory Bowel Disease DOI Open Access
Lea Pueschel,

Sonja Nothacker,

Lisa Kühn

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 14(1), С. 137 - 137

Опубликована: Дек. 29, 2024

Background/Objectives: Inflammatory bowel disease (IBD) affects gastrointestinal function and may alter fecal flatulence odor (intestinal odor) due to changes in inflammation, the gut microbiome, metabolism. Investigating relationship between dietary habits intestinal IBD is critical given diet, health, microbiome diversity. Methods: We performed a cohort analysis of monocentric, cross-sectional study at tertiary referral center compared perception 233 patients (n = 117 women) with that 96 healthy controls (HCs) 67 women). In addition short screening questionnaire on highly processed foods (sQ-HPF), behavior (Food Frequency Questionnaire (FFQ)), clinical (HBI, PMS) biochemical (CRP, calprotectin) parameters activity, adherence Mediterranean diet were assessed. Results: A notable predisposition towards elevated levels malodor was identified when HC group. The conjunction revealed more pronounced associations collective than collective. data further indicated that, comparison those remission, individuals an active status exhibited higher prevalence malodor. adjusted logistic regression influence disease- diet-specific factors IBD, male sex as significant risk factor. Conclusions: This highlights significance management symptoms, particular focus odor. Individuals demonstrated propensity for HC, amplifying this prevalence. Dietary showed stronger group individuals, suggesting distinct interaction patterns health these populations.

Язык: Английский

Процитировано

2

The effects of Mineral Waters from Slănic Moldova's Spring 1 and Spring 1 bis on Fibroblast activity: An In Vitro Study DOI Creative Commons
Constantin Munteanu,

Mihail Hoteteu,

Diana Munteanu

и другие.

Balneo and PRM Research Journal, Год журнала: 2023, Номер Vol.14, no.3, С. 591 - 591

Опубликована: Сен. 1, 2023

Primary fibroblast cultures obtained from Wistar rats were investigated with a focus on two vital physiological mechanisms: inflammatory processes and oxidative stress balance. These are believed to be affected by mud sulfurous natural mineral waters, forming the fundamental biological basis for understanding therapeutic effects of these substances. Existing scientific research highlights that various cell types, including fibroblasts, recruited during inflammation. cells respond wide array intercellular microenvironmental signals, leading regulated production both pro- anti-inflammatory mediators. Examples include cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, well chemokines enzymes like cyclooxygenase (COX)-2. Together, play roles in modulating response.

Язык: Английский

Процитировано

5