World Journal of Food Science and Technology,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 21, 2023
Introduction:
Herbal
products
play
a
crucial
role
in
traditional
Chinese
medicine,
offering
holistic
approach
to
disease
treatment.Botanicals
and
their
active
components
have
shown
promise
addressing
depression-like
symptoms.Unlike
antidepressant
medications,
botanicals
offer
natural
alternative
with
milder
side
effects.This
study
explores
the
potential
of
botanical
compounds
as
antidepressants.Natural
Products
for
Low
Mood
Management:
Crocus
Sativus
(Saffron):
Derived
from
sativus
flower,
saffron
has
demonstrated
effectiveness
relieving
symptoms
mild
moderate
anxiety,
comparable
standard
antidepressants.Cost-effective
petal
extracts
proven
be
viable
alternatives.Rhodiola
Rosea
(Rhodiola):
Used
traditionally
enhance
physical
mental
performance,
Rhodiola
reducing
anxiety
depression
symptoms.Development
SR45:
Bioactive
hold
significant
enhancing
nutraceutical
functionality.Encapsulation
systems
emerged
transformative
technology
improving
bioactive
stability
bioavailability.SR45,
developed
on
lipid
basis
advanced
encapsulation
techniques,
aims
bioavailability
key
ingredients.Preliminary
Clinical
Results
Obtained
A
randomized
clinical
trial
evaluated
SR45's
efficacy
safety
individuals
low
mood.Participants
taking
SR45
experienced
statistically
reduction
compared
placebo
group.Both
groups
showed
improvement,
highlighting
effect,
essential
robust
execution.No
adverse
events
related
were
observed,
indicating
its
safety.Conclusions:
Daily
consumption
capsules
over
8
weeks
led
symptoms.SR45
also
was
found
safe
at
specified
doses
8-week
period.This
preliminary
suggests
that
holds
supplement
managing
mood.Further
research
is
warranted
validate
these
findings
explore
larger
population.
Arabian Journal of Chemistry,
Год журнала:
2023,
Номер
17(2), С. 105570 - 105570
Опубликована: Дек. 20, 2023
Many
different
species
of
Rhodiola
are
traditional
botanical
medicines
with
various
effects,
and
their
roots
rhizomes
the
medicinal
parts,
which
have
been
recorded
in
many
ancient
medical
books.
The
2020th
edition
Chinese
Pharmacopoeia
stipulates
crenulata
(Hook.
f.
et
Thoms.)
H.
Ohba
(R.
crenulata)
as
only
species.
However,
wild
resources
R.
gradually
decreasing,
it
is
difficult
to
achieve
artificial
cultivation
nowadays.
It
important
find
several
alternative
crenulata.
In
present
study,
an
integrated
strategy
based
on
chemical
profiling,
disease
module-guided
network
pharmacology,
quantitative
analysis
(CDMQ)
has
developed
estimate
characteristics,
determine
active
components
related
modules,
discover
potential
quality
markers,
identify
a
step-by-step
manner
for
9
Rhodiola.
Firstly,
total
109
compounds
were
identified
accordance
retention
times,
accurate
masses
characteristic
MS/MS
fragment
patterns,
mainly
included
phenylpropanoid
glycosides,
gallic
acid
flavonoids
flavanols,
organic
acids,
others.
Subsequently,
pharmacology
was
performed
targets
compounds.
combination
limit
detection
UPLC-QQQ-MS/MS,
12
components.
enriched
modules
circulatory
system,
mouth,
respiratory
skin
connective
tissue
showed
close
relationship
efficacy
also
revealed
that
salidroside,
rhodiosin,
epicatechin
gallate,
catechin
6'-O-galloylsalidroside
changed
significantly
be
served
markers
Among
species,
kirilowii
(Regel)
Maxim
kirilowii)
sacra
(Prain
ex
Hamet)
S.
Fu
sacra)
could
probably
used
Overall,
this
study
established
solid
foundation
provided
theoretical
guidance
prediction
clinical
application,
control
Anadolu Kliniği Tıp Bilimleri Dergisi,
Год журнала:
2024,
Номер
29(3), С. 304 - 317
Опубликована: Май 14, 2024
Aim:
Harmaline
(HR)
is
a
monoamine
oxidase
inhibitor
(MAOi)
and
antioxidant
alkaloid
obtained
from
Banisteriopsis
caapi
Peganum
harmala,
where
experimental
studies
have
been
conducted
to
support
modern
medicine.
The
electrophysiological
impact
of
short-term
long-term
HR
treatment
on
the
penicillin
G-induced
epileptic
model
in
rats
was
examined
this
study.
Methods:
Eighty-four
adult
male
Wistar
were
randomly
assigned
two
groups:
one
received
single
dose/day
HR,
other
repeated
doses/days
HR.
Each
group
further
divided
into
six
subgroups
based
dose
(10,
50,
100
mg/kg).
Epileptiform
activity
(EA)
triggered
groups
with
intracortical
administration.
Electrophysiological
data
collected
analyzed
using
electrocorticography
(ECoG).
serum
levels
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPx),
reductase
(GR)
measured
Enzyme-Linked
Immuno
Sorbent
Assay
(ELISA)
method
assess
free
radical
scavenger
effects
latency,
frequency,
amplitude
EA
waves
marker
statistically.
Results:
There
no
observed
sham
group.
Nevertheless,
results
showed
that
both
acute
chronic
increased
seizure
threshold
dose-dependently
(p
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Май 30, 2024
Objectives
Abnormal
hippocampal
neurodevelopment,
particularly
in
the
dentate
gyrus
region,
may
be
a
key
mechanism
of
attention-deficit/hyperactivity
disorder
(ADHD).
In
this
study,
we
investigate
effect
most
commonly
used
Chinese
herb
for
treatment
ADHD,
Rehmanniae
Radix
Preparata
(RRP),
on
behavior
and
neurodevelopment
spontaneously
hypertensive
rats
(SHR).
Methods
Behavior
tests,
including
Morris
water
maze
(MWM)
test,
open
field
test
(OFT)
elevated
plus
(EPM)
were
performed
to
assess
RRP
hyperactive
impulsive
behavior.
Hippocampal
was
characterized
by
transmission
electron
microscopy,
immunofluorescence,
Golgi
staining
Nissl
approaches.
Regulatory
proteins
such
as
Trkb,
CDK5,
FGF2/FGFR1
examined
Western
blot
analysis.
Results
The
results
showed
that
could
effectively
control
spontaneous
improve
spatial
learning
memory
ability.
significantly
reduced
neuronal
loss
increased
number
stem
cells,
promoted
synaptic
plasticity.
addition,
FGF/FGFR
signaling
upregulated
after
treatment.
Conclusion
can
reduce
ameliorate
neurodevelopmental
abnormalities
ADHD
rat
model.
World Journal of Food Science and Technology,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 21, 2023
Introduction:
Herbal
products
play
a
crucial
role
in
traditional
Chinese
medicine,
offering
holistic
approach
to
disease
treatment.Botanicals
and
their
active
components
have
shown
promise
addressing
depression-like
symptoms.Unlike
antidepressant
medications,
botanicals
offer
natural
alternative
with
milder
side
effects.This
study
explores
the
potential
of
botanical
compounds
as
antidepressants.Natural
Products
for
Low
Mood
Management:
Crocus
Sativus
(Saffron):
Derived
from
sativus
flower,
saffron
has
demonstrated
effectiveness
relieving
symptoms
mild
moderate
anxiety,
comparable
standard
antidepressants.Cost-effective
petal
extracts
proven
be
viable
alternatives.Rhodiola
Rosea
(Rhodiola):
Used
traditionally
enhance
physical
mental
performance,
Rhodiola
reducing
anxiety
depression
symptoms.Development
SR45:
Bioactive
hold
significant
enhancing
nutraceutical
functionality.Encapsulation
systems
emerged
transformative
technology
improving
bioactive
stability
bioavailability.SR45,
developed
on
lipid
basis
advanced
encapsulation
techniques,
aims
bioavailability
key
ingredients.Preliminary
Clinical
Results
Obtained
A
randomized
clinical
trial
evaluated
SR45's
efficacy
safety
individuals
low
mood.Participants
taking
SR45
experienced
statistically
reduction
compared
placebo
group.Both
groups
showed
improvement,
highlighting
effect,
essential
robust
execution.No
adverse
events
related
were
observed,
indicating
its
safety.Conclusions:
Daily
consumption
capsules
over
8
weeks
led
symptoms.SR45
also
was
found
safe
at
specified
doses
8-week
period.This
preliminary
suggests
that
holds
supplement
managing
mood.Further
research
is
warranted
validate
these
findings
explore
larger
population.
