The hydrogen sulfide donor sodium thiosulfate limits inflammation but aggravate smooth muscle cells apoptosis and aneurysm progression in a mouse model of abdominal aortic aneurysm DOI Creative Commons

Clémence Bechelli,

Diane Macabrey,

Florian Caloz

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 17, 2023

Abstract Intro The prevalence of abdominal aortic aneurysm (AAA) is constantly progressing with the aging global population. AAA rupture has a devastating 80% mortality rate and there no treatment to slow-down progression. Hydrogen sulfide (H 2 S) ubiquitous redox-modifying gasotransmitter produced in cardiovascular system via reverse trans-sulfuration pathway by cystathionine γ-lyase (CSE). H S protective properties on system, including anti-inflammatory antioxidant effects. Here, we hypothesized that sodium thiosulfate (STS), clinically relevant source S, would limit growth. Methods 8-12 weeks old male WT or Cse -/- mice C57BL/6J genetic background were submitted model topical elastase application aorta β-aminopropionitrile fumarate drinking water for post-op. Sodium (STS) was given post-op until collection. In vitro experiments conducted assess effect STS pro-inflammatory cytokines interleukin-1 β 6 tumor necrosis factor α primary human vascular smooth muscle cell (VSMC). Results Surprisingly, increased elastin degradation, size rupture, despite reducing infiltration macrophages, antigen-presenting cells lymphocytes mice. Conversely, impaired production developed smaller than immune cells. reduced VSMC coverage, possibly lowered proliferation, promoted loss extracellular matrix (ECM) breakdown. vitro, aggravated cytokine-induced VSMCs apoptosis. Conclusion paradoxical growth, inflammation while simultaneously impeding favorable remodeling, resulting bigger periadventitial elastase. This study identifies negative this environment, highlighting complex role deleterious progression significant, especially growing use clinical settings various indications.

Язык: Английский

A coumarin-based near infrared fluorescent probe for the detection of hydrogen sulfide/sulfur dioxide and mitochondrial viscosity DOI
Haiwei Liu,

Mengyao Yuan,

Yanjin Wang

и другие.

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 418, С. 136243 - 136243

Опубликована: Июль 4, 2024

Язык: Английский

Процитировано

14
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST DOI
Hans‐Georg Sprenger, Melanie J. Mittenbühler, Yizhi Sun

и другие.

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Self-immolative poly(thiocarbamate) with localized H2S signal amplification for precise cancer imaging and therapy DOI Creative Commons

Qingyu Zong,

Jun Li,

Qing Xu

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 30, 2024

Hydrogen sulfide is essential in numerous physiological and pathological processes has emerged as a promising cancer imaging signaling molecule potentially versatile therapeutic agent. However, the endogenous levels of hydrogen remain insufficient to perform its biological functions, thus, developing novel strategies that amplify signals at lesion sites increasing interest. In this work, nanoplatform (SNP) based on sulfide-responsive self-immolative poly(thiocarbamate) with localized signal amplification capability developed encapsulate fluorescent probe (e.g., hemicyanine dye; p-Cy) or an anticancer prodrug doxorubicin; p-DOX) form nanoprobe (SNP

Язык: Английский

Процитировано

7
Ethylene and hydrogen sulfide regulate hexavalent chromium toxicity in two pulse crops: Implication on growth, photosynthetic activity, oxidative stress and ascorbate glutathione cycle DOI
Tajammul Husain, Sheo Mohan Prasad, Vijay Pratap Singh

и другие.

Plant Physiology and Biochemistry, Год журнала: 2024, Номер 216, С. 109170 - 109170

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

4
CSE/H2S Signaling Pathways in Enhancing Muscle Function and Insulin Sensitivity During Exercise DOI Open Access
Miaomiao Xu, Xiaoguang Liu,

Danhong Hu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1741 - 1741

Опубликована: Фев. 18, 2025

Exercise plays a crucial role in maintaining metabolic health, enhancing muscle function, and improving insulin sensitivity, thereby preventing diseases such as type 2 diabetes. Emerging evidence highlights the significance of cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) signaling pathway pivotal regulator molecular physiological adaptations induced by exercise. This review comprehensively examines biosynthesis metabolism H2S, its distribution different tissues, mechanisms which CSE/H2S influences contraction, repair, protein synthesis. Additionally, it explores how modulates pathways, glucose uptake, lipid metabolism, sensitivity. The potential H2S donors exercise supplements is also discussed, highlighting their ability to improve performance health. Current research advancements, including application multi-omics approaches, are reviewed provide deeper understanding complex networks involved. Furthermore, challenges future directions addressed, emphasizing need for further mechanistic studies clinical applications. underscores therapeutic targeting optimize benefits

Язык: Английский

Процитировано

0
Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST DOI Open Access
Hans‐Georg Sprenger, Melanie J. Mittenbühler, Yizhi Sun

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 10, 2024

Abstract Ergothioneine (EGT) is a diet-derived, atypical amino acid that accumulates to high levels in human tissues. Reduced EGT have been linked age-related disorders, including neurodegenerative and cardiovascular diseases, while supplementation protective broad range of disease aging models mice. Despite these promising data, the direct physiologically relevant molecular target has remained elusive. Here we use systematic approach identify how mitochondria remodel their metabolome response exercise training. From this find muscle upon Proteome-wide thermal stability studies 3-mercaptopyruvate sulfurtransferase (MPST) as EGT; binds activates MPST, thereby boosting mitochondrial respiration training performance Together, data first establish EGT-MPST axis mechanism for regulating function performance.

Язык: Английский

Процитировано

3
Recent advances in the role of hydrogen sulfide in age-related diseases DOI

C. Zhang,

Yan Wang, Yuqing Jin

и другие.

Experimental Cell Research, Год журнала: 2024, Номер 441(2), С. 114172 - 114172

Опубликована: Июль 23, 2024

Язык: Английский

Процитировано

2
Recent Developments On Activatable Turn‐On Fluorogenic Donors of Hydrogen Sulfide (H2S) DOI

Roopjyoti Misra,

Hirak Jyoti Bhuyan, A. Dutta

и другие.

ChemMedChem, Год журнала: 2024, Номер 19(16)

Опубликована: Май 15, 2024

Hydrogen sulfide (H

Язык: Английский

Процитировано

1
Sargassum Inundations and the Risk of Hypertension Disorders Among Pregnant Women Living in the French Caribbean Island of Martinique DOI Open Access
Rishika Banydeen,

Mickael Rejaudry Lacavalerie,

Loic Savoyen

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(12), С. 1612 - 1612

Опубликована: Дек. 1, 2024

Since 2011, Caribbean territories have experienced massive and repeated sargassum seaweed inundations. Once on shore, degradation through anaerobic metabolism elicits the release of many noxious molecules, including hydrogen sulfide (H2S) ammonia (NH3). H2S has been long recognized as a malodorous highly toxic gas, while chronic exposure not extensively explored. Our objective was to assess whether pregnant women exposed emissions would be more prone developing hypertensive disorders compared unexposed women. We conducted retrospective study 3020 at Obstetrics Department University Hospital Martinique between 25 January 2016 31 July 2020. Exposure defined distance less than 2 km residence/workplace strandings. Multivariate regression retained age, body mass index, sickle cell disease, primipaternity, gestational diabetes independent predictors events in Jointly with previous studies from our group, this highlights deleterious effects human health individuals chronically low moderate concentrations.

Язык: Английский

Процитировано

1
Rab8a serves as a valuable biomarker of esophageal squamous cell carcinoma DOI Creative Commons
Rong Liu,

Zhanting Kang,

Ting Gan

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Янв. 9, 2024

Abstract Background Esophageal carcinoma (ESCA) is a digestive tract malignancy with high morbidity in China, among which esophageal squamous cell (ESCC) accounts for 90% of the confirmed cases. Rab8a member Ras small GTPase superfamily, and it has been shown to play an important role endometrial cancer (EC) hepatocellular (HCC). However, function ESCC are currently unclear. This study aimed investigate as biomarker diagnosis ESCC. Methods The first used TIMER2.0, GEPIA UALCAN analyze expression variety clinically common malignancies including ESCC, followed by real-time PCR (quantitative PCR, qPCR), Western blot, immunohistochemical (IHC) ，and series vitro biological experiments Results highly expressed cells tissues.overexpression can promote proliferation migration ,while knockdown its inhibit Correlation analysis revealed positive correlation between NDUFA1, CYC1 public GEO databases. Therefore, may progression activating mitochondrial respiration. Conclusions demonstrated that upregulated provides rationale clinical screening new therapeutic targets

Язык: Английский

Процитировано

0