Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems

Molecular Medicine Reports, Год журнала: 2024, Номер 30(1)

Опубликована: Май 15, 2024

Physiological stress such as excessive reactive oxygen species (ROS) production may contribute normal fibroblasts activation into cancer‑associated fibroblasts, which serve a crucial role in certain types of cancer pancreatic, breast, liver and lung cancer. The present study aimed to examine the cytoprotective effects luteolin (3',4',5,7‑tetrahydroxyflavone) against hydrogen peroxide (H₂O₂)‑generated oxidative fibroblasts. To H₂O₂‑induced damages, cell viability, sub‑G₁ population, nuclear staining with Hoechst 33342, lipid peroxidation comet assays were performed. evaluate on protein expression level apoptosis, western blot assay was assess antioxidant luteolin, detection ROS using H₂DCFDA staining, O₂‑ ·OH electron spin resonance spectrometer enzyme activity In cell‑free chemical system, scavenges superoxide anion hydroxyl radical generated by xanthine/xanthine oxidase Fenton reaction (FeSO₄/H₂O₂). Furthermore, Chinese hamster (V79‑4) treated H₂O₂ showed significant increase cellular ROS. Intracellular levels damage components lipids DNA H₂O₂‑treated cells significantly decreased pretreatment. Luteolin increased impaired following treatment prevented H₂O₂‑mediated apoptosis. suppressed active caspase‑9 caspase‑3 while increasing Bcl‑2 decreasing Bax levels. Additionally, restored glutathione that reduced response H₂O₂. Moreover, enhanced expressions dismutase, catalase, peroxidase, heme oxygenase‑1. Overall, these results indicated inhibits upregulating enzymes.

Язык: Английский

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NRF2 in kidney physiology and disease

Physiological Reports, Год журнала: 2024, Номер 12(5)

Опубликована: Фев. 28, 2024

Abstract The role of NRF2 in kidney biology has received considerable interest over the past decade. transcriptionally controls genes responsible for cellular protection against oxidative and electrophilic stress anti‐inflammatory functions. is expressed throughout plays a salt water handling. In disease, animal studies show that protects tubulointerstitial damage reduces interstitial fibrosis tubular atrophy, may slow progression polycystic disease. However, proteinuric glomerular diseases controversial. Although inducer, bardoxolone methyl (CDDO‐Me), increases filtration rate humans, it not been shown to disease diabetic Alport syndrome. Furthermore, was associated with negative effects on fluid retention, proteinuria, blood pressure. Several replicate findings worsened proteinuria more rapid although controversy exists. It clear further study needed better understand kidney. This review summarizes available data clarify promise risks targeting activity

Язык: Английский

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Taxifolin Protects Against 5-Fluorouracil-Induced Cardiotoxicity in Mice Through Mitigating Oxidative Stress, Inflammation, and Apoptosis: Possible Involvement of Sirt1/Nrf2/HO-1 Signaling

Cardiovascular Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Язык: Английский

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Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin

AAPS Open, Год журнала: 2025, Номер 11(1)

Опубликована: Март 3, 2025

Abstract Objective Acute kidney injury (AKI) occurs in approximately one-third of patients treated with cisplatin and there is an outstanding need for mitigation strategies to decrease the frequency severity cisplatin-induced AKI. This study evaluated bardoxolone methyl (BARD) as a nephroprotectant multidose, tumor-bearing mouse model BARD attractive therapeutic intervention due its ability protect against nephrotoxicity by activating Nrf2 previous reports suggesting anti-tumorigenic effects. Methods In this study, CMT167 mice were four weekly doses or without survival, tumor growth, clinical histological measures Kidney and/or function quantification urinary molecule-1 (KIM-1) serum creatinine (SCr) levels well histopathology. Results Compared receiving alone, co-treatment significantly enhanced survival ( p = 0.01). Moreover, prevented elevation KIM-1 concentrations early one week after treatment < 0.01) – response that was observed throughout 4-week period. Cisplatin increased SCr weeks, which co-administration decreased burden compared vehicle-treated 0.05 two doses) not altered co-treatment. Conclusions Overall, results demonstrate has potential improve reduce cisplatin, it could be used mitigate

Язык: Английский

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Morroniside alleviates cisplatin-induced renal injury and gut dysbiosis via the gut–kidney axis and ferroptosis

International Immunopharmacology, Год журнала: 2025, Номер 153, С. 114430 - 114430

Опубликована: Март 17, 2025

Язык: Английский

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Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei

Phytochemistry, Год журнала: 2024, Номер 219, С. 113984 - 113984

Опубликована: Янв. 22, 2024

Язык: Английский

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Recruitment or activation of mast cells in the liver aggravates the accumulation of fibrosis in carbon tetrachloride-induced liver injury

Molecular Immunology, Год журнала: 2024, Номер 170, С. 60 - 75

Опубликована: Апрель 15, 2024

Язык: Английский

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Dietary Probiotic Pediococcus acidilactici GKA4, Dead Probiotic GKA4, and Postbiotic GKA4 Improves Cisplatin-Induced AKI by Autophagy and Endoplasmic Reticulum Stress and Organic Ion Transporters

Nutrients, Год журнала: 2024, Номер 16(20), С. 3532 - 3532

Опубликована: Окт. 18, 2024

Background/Objectives: Acute kidney injury (AKI) syndrome is distinguished by a quick decline in renal excretory capacity and usually diagnosed the presence of elevated nitrogen metabolism end products and/or diminished urine output. AKI frequently occurs hospital patients, there are no existing specific treatments available to diminish its occurrence or expedite recovery. For an extended period food industry, Pediococcus acidilactici has been robust bacteriocin production, effectively inhibiting pathogen growth during fermentation storage. Methods: In this study, aim assess effectiveness P. GKA4, dead probiotic postbiotic GKA4 against cisplatin-induced animal model. The experimental protocol involves ten-day oral administration mice, with cisplatin intraperitoneal injection being given on seventh day induce AKI. Results: findings indicated significant alleviation histopathological changes serum biomarkers nephrotoxicity. expression levels HO-1 decreased Nrf-2 proteins. addition, significantly reduced apoptosis-related proteins (Bax, Bcl-2, caspase 3), autophagy-related (LC3B, p62, Beclin1), endoplasmic reticulum (ER) stress-related (GRP78, PERK, ATF-6, IRE1, CHOP, Caspase 12) tissues. Notably, also upregulated related organic anion transporters cation transporters. Conclusions: Overall, potential therapeutic benefits significant, particularly after treatment. This achieved modulating apoptosis, autophagy, ER stress, transporter alleviate oxidative stress.

Язык: Английский

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Renal Health Through Medicine–Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms

Nutrients, Год журнала: 2024, Номер 16(20), С. 3530 - 3530

Опубликована: Окт. 18, 2024

As an ancient concept and practice, "food as medicine" or "medicine-food homology" is receiving more attention these days. It a tradition in many regions to intake medicinal herbal food for potential health benefits various organs systems including the kidney. Kidney diseases usually lack targeted therapy face irreversible loss of function, leading dialysis dependence. most important organ endogenous metabolite exogenous nutrient excretion, status kidney could be closely related daily diet. Therefore, rich antioxidative, anti-inflammation micronutrients are ideal supplements protection. Recent studies have also discovered its impact on "gut-kidney" axis.

Язык: Английский

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Cisplatin induces acute liver injury by triggering caspase-3/GSDME-mediated cell pyroptosis

Hepatobiliary & pancreatic diseases international, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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