Antioxidants, Год журнала: 2024, Номер 13(8), С. 928 - 928
Опубликована: Июль 30, 2024
Papain (PN) is a proteolytic enzyme derived from
Язык: Английский
Molecules, Год журнала: 2024, Номер 29(4), С. 865 - 865
Опубликована: Фев. 15, 2024
The biochemical characteristics of polyphenols contribute to their numerous advantageous impacts on human health. existing research suggests that plant phenolics, whether consumed orally or applied directly the skin, can be beneficial in alleviating symptoms and avoiding development many skin disorders. Phenolic compounds, which are both harmless naturally present, exhibit significant potential terms counteracting effects damage, aging, diseases, wounds, burns. Moreover, play a preventive role possess ability delay progression several disorders, ranging from small discomforting severe potentially life-threatening ones. This article provides concise overview recent therapeutic application for conditions. It specifically highlights studies have investigated clinical trials use polyphenol-based nanoformulations treatment different ailments.
Язык: Английский
Процитировано
23
Life, Год журнала: 2024, Номер 14(1), С. 114 - 114
Опубликована: Янв. 12, 2024
Psoriasis is a chronic immune-mediated disease, linked to local and systemic inflammation predisposing patients higher risk of associated comorbidities. Cytokine levels are not widely available for disease progression monitoring due high costs. Validated low-cost reliable markers needed assessing outcome. This study aims assess the reliability blood-count-derived inflammatory as predictors identify prognostic factors severity. Patients fulfilling inclusion criteria were enrolled in this study. divided into three groups according severity measured by Body Surface Area (BSA) score: mild, moderate, severe psoriasis. White blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), derived (d-NLR), immune index (SII), response (SIRI), aggregate (AISI) positively correlated with (
Язык: Английский
Процитировано
7
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Июнь 12, 2024
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by itching, epidermal barrier dysfunction, and an unbalanced reaction. AD pathophysiology involves dysregulated immune response driven T helper-2 cells. Many factors, including reactive oxygen species (ROS), are involved in pathogenesis causing cellular damage inflammation resulting dysfunction. This narrative review aims to provide comprehensive overview of the role natural molecules antioxidant compounds, highlighting their potential therapeutic value prevention management. They include vitamin D, E, pyridoxine, Vitamin C, carotenoids, melatonin. Some studies report statistically significant association between levels improvement AD, however, there conflicting results which supplementation, especially did not result AD. Therefore, clinical efficacy these dietary nutritional factors treatment needs be further evaluated trials. Meanwhile, antioxidants can incorporated into management patients personalized manner, tailored severity disease, comorbidities, individual needs.
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1316 - 1316
Опубликована: Янв. 21, 2024
Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects individuals of all age groups, manifesting as spectrum symptoms varying from mild to severe. Allergen immunotherapy (AIT) involves the administration allergen extracts and has emerged potential treatment strategy for modifying immune responses. Its pathogenesis epidermal barrier dysfunction, microbiome imbalance, dysregulation, environmental factors. Existing strategies encompass topical steroids systemic agents, while AIT under investigation immune-modifying alternative. Several studies have shown reductions in severity scoring atopic (SCORAD) scores, daily rescue medication use, visual analog scale (VAS) scores following AIT. Biomarker changes include increased IgG4 levels decreased eosinophil counts. This review provides valuable insights future research clinical practice, exploring viable option management AD.
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2544 - 2544
Опубликована: Март 12, 2025
Excessive amounts of free-oxygen radicals produced during inflammation induce oxidative stress and lead to cell damage, thus delaying the transition into proliferation in wound healing process. Oxidative on skin cells also plays an important role pathogenesis inflammatory diseases. The aim planned vitro studies was assess mechanisms regenerative action protection against three oil emulsions from transgenic (GMO) flax varieties M, B, MB a linseed emulsion traditional NIKE oil. Antioxidant gene-protective properties were identified for tested healthy model under stress. wound-healing potential these assessed proliferation, cycle, migration, apoptosis necrosis assays. conducted research presented that are safe human because they do not cancer and, at same time, migration processes normal cells. Additionally, their use increases ability eliminate damaged Transgenic oils provide effect increased antioxidant effect, resulting stress, which atopic dermatitis psoriasis. Linen B has best protective epidermis cancer, is probably due presence amount stigmasterol its composition along with appropriate content polyphenol compounds, as well oleic linoleic acids.
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2024, Номер 12(3), С. 517 - 517
Опубликована: Фев. 25, 2024
This study aimed to comprehensively analyze the problem of overweight and obesity among psoriatic patients by investigating influence body mass composition, anhedonia depression, environmental factors FTO gene polymorphisms. Methods: The enrolled 30 or obese adult with chronic plaque psoriasis volunteers (northern Poland region, Caucasian population). Mood disorders, composition using bioelectrical impedance analysis (BIA) polymorphisms (rs9939609, rs1558902) tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) were assessed. Results: Results revealed significantly higher visceral adipose tissue levels in (5.23 ± 2.29 [L] vs. 3.41 1.86 [L]), p = 0.001), especially men, along elevated rates moderate severe depression (26.67% 6.67% 13.33% 3.33%, 0.048 respectively). Additionally, correlated waist–hip ratio differences both groups. Conclusions: highlights importance evaluating beyond index, recognizing its on associated conditions like depression. may serve as a potential genetic link between obesity, warranting further research for validation. Adiposity emerges key modifiable risk factor, underscoring clinical implications complexities management.
Язык: Английский
Процитировано
2
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(9), С. 2452 - 2452
Опубликована: Апрель 23, 2024
The risk of developing non-melanoma skin cancers (NMSCs) in patients with psoriasis is highly debated, and, to date, there no unambiguous consensus opinion. Psoriasis known be related an increased likelihood other comorbidities such as psoriatic arthritis, obesity, metabolic syndrome, depression, and cardiovascular disease. Regarding cancer risk, previous studies have reported a greater tendency for the development cutaneous T-lymphomas colon, breast, kidney, lung cancers. Furthermore, data from network meta-analyses shown that higher squamous cell carcinomas (SCCs) and/or basal (BCCs). Multiple factors may contribute NMSCs patients, ranging immunosuppression induced by biologic agents phototherapy. However, extent which each factor impact this has not been entirely assessed. aim study was evaluate observed at least 5 years, directly comparing only treated phototherapy anti-tumor necrosis α (TNFα) agents, naive systemic treatments or
Язык: Английский
Процитировано
2
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(9), С. 2552 - 2552
Опубликована: Апрель 26, 2024
Background: Guselkumab is the first approved human IgG1λ monoclonal antibody selectively targeting p19 subunit of IL23. Its effectiveness and safety were widely reported by clinical trials. However, these results must be confirmed in real life since its deals with more complicated subjects respect to Currently, real-life data on use guselkumab following treatment failure ustekinumab are limited, existing studies usually show a small cohort and/or reduced follow-up period. In this context, aim our study was evaluate patients who previously did not respond after up 3 years treatment. Methods: A multicenter retrospective performed. The enrolled affected moderate-to-severe plaque psoriasis undergoing attending Psoriasis Center nine different centers Campania region Italy. Demographic features collected for each patient at baseline. Moreover, severity adverse events (AEs) visit (week (W)16-W36-W52-W104-W156). Results: total 112 (70 male, 62.5%; mean age 54.8 ± 11.7 old) enrolled. Of these, 48 (42.9%), 34 (30.4%), 16 (14.3%) reached 1, 2, years, respectively, under guselkumab. statistically significant improvement observed W16, sustained timepoint W156. No serious AEs collected. sub analysis body mass index, involvement difficult-to-treat areas, presence psoriatic arthritis (PsA) showed that PsA or palmoplantar associated W16 W36, without differences from W52. contrast, efficacy does seem BMI, fingernails, location genital scalp area. Conclusions: To sum up, long-term discontinuation 156 weeks
Язык: Английский
Процитировано
2
Biomedicines, Год журнала: 2024, Номер 12(3), С. 587 - 587
Опубликована: Март 6, 2024
Given that oxidative stress represents an important etiological factor in the pathogenesis of psoriasis, aim this study was to assess effects different therapeutic approaches, methotrexate, secukinumab, and ustekinumab on systemic biomarkers psoriatic patients. This involved 78 patients, divided into group treated with methotrexate (23 patients), secukinumab (28 (27 15 healthy controls. Oxidative (index lipid peroxidation measured as TBARS, nitrites (NO
Язык: Английский
Процитировано
1
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1627 - 1627
Опубликована: Июль 23, 2024
Psoriasis induces systemic atherosclerosis, but its impact on cerebrovascular function remains unclear. However, stroke prevention must be considered in psoriasis, as it is commonly comorbid with classic cardiovascular risk factors. Thus, the aim of study to assess cerebral microvasculature and confounders patients psoriasis. The protocol included autoregulation assessment measurements vasomotor reactivity reserve (VMRr) middle arteries use a Transcranial Doppler (TCD) 50 psoriasis without events (46; 21-74 years) 26 healthy controls (41; 29-58 years). Analyses VMRr relationships course, comorbidities, inflammatory markers intima-media thickness (IMT) were performed. showed that was lower (64% vs. 76%,
Язык: Английский
Процитировано
0