Molecules,
Год журнала:
2024,
Номер
29(22), С. 5314 - 5314
Опубликована: Ноя. 11, 2024
Alzheimer's
disease
(AD)
involves
a
complex
pathophysiology
with
multiple
interconnected
subpathologies,
including
protein
aggregation,
impaired
neurotransmission,
oxidative
stress,
and
microglia-mediated
neuroinflammation.
Current
treatments,
which
generally
target
single
subpathology,
have
failed
to
modify
the
disease's
progression,
providing
only
temporary
symptom
relief.
Multi-target
drugs
(MTDs)
address
several
aggregation
of
pathological
proteins.
In
this
review,
we
cover
hybrid
molecules
published
between
2014
2024.
We
offer
an
overview
strategies
employed
in
drug
design
approaches
that
led
notable
improvements
reduced
hepatotoxicity.
Our
aim
is
insights
into
potential
development
new
drugs.
This
highlights
multi-target
featuring
heterocycles
International Immunopharmacology,
Год журнала:
2025,
Номер
155, С. 114644 - 114644
Опубликована: Апрель 10, 2025
Monomeric
C-reactive
protein
(mCRP)
is
a
pro-inflammatory
molecule
generated
by
the
dissociation
of
native
CRP.
Clinical
and
experimental
studies
suggest
that
mCRP
deposition
in
brain
induces
Alzheimer's
disease
(AD)
pathology
cognitive
loss.
Pathological
neuroinflammation
increasingly
suggested
as
relevant
AD.
Innovative
therapies
against
are
desperately
needed,
inhibitors
enzyme
soluble
epoxide
hydrolase
(sEH)
promising
new
generation
anti-inflammatory
drugs.
Mouse
primary
microglia
BV2
cell
line
cultures
were
exposed
to
analyze
its
mechanisms.
sEH
inhibitors,
both
newly
synthesized
UB-SCG-55
UB-SCG-65,
reference
agent
TPPU,
tested
for
their
action
mCRP.
Phenotypic
changes
analyzed
through
imaging
techniques,
well
molecular
analysis
inflammatory
mediators
gene
activation
pathways.
Results
show
triggers
response
three
main
pathways:
iNOS,
NLRP3,
COX-2,
followed
increased
cytokine
generation.
Polarization
toward
M1-like
phenotype
was
confirmed
morphological
analysis.
Also,
can
bind
cross
membrane,
providing
further
insight
into
mechanisms
action.
effective
induction
reactive
microglial
phenotype.
The
first-line
compound
emerged
most
potent
injury.
Therefore,
direct
provides
evidence
role
triggering
exacerbating
neurodegenerative
diseases
with
neuroinflammatory
component,
such
Furthermore,
protection
given
confirms
potential
innovative
drugs
deleterious
effects
neuroinflammation.
Biomedicines,
Год журнала:
2024,
Номер
12(5), С. 1009 - 1009
Опубликована: Май 3, 2024
Hypovolemic
shock
is
a
circulatory
failure,
due
to
loss
in
the
effective
circulating
blood
volume,
that
causes
tissue
hypoperfusion
and
hypoxia.
This
condition
stimulates
reactive
oxygen
species
(ROS)
pro-inflammatory
cytokine
production
different
organs
also
central
nervous
system
(CNS).
Levosimendan,
cardioprotective
inodilator,
dobutamine,
β1-adrenergic
agonist,
are
commonly
used
for
treatment
of
hypovolemic
shock,
thanks
their
anti-inflammatory
antioxidant
effects.
For
this
reason,
we
aimed
at
investigating
levosimendan
dobutamine’s
neuroprotective
effects
an
“in
vitro”
model
lipopolysaccharide
(LPS)-induced
neuroinflammation.
Human
microglial
cells
(HMC3)
were
challenged
with
LPS
(0.1
µg/mL)
induce
inflammatory
phenotype
then
treated
(10
µM)
or
dobutamine
(50
24
h.
Levosimendan
significantly
reduced
ROS
levels
markedly
increased
Nrf2
HO-1
protein
expression
LPS-challenged
cells.
decreased
p-NF-κB
turned
off
NLRP3
inflammasome
together
its
downstream
signals,
caspase-1
IL-1β.
Moreover,
reduction
TNF-α
IL-6
increase
IL-10
LPS-stimulated
HMC3
was
observed
following
treatment.
In
conclusion,
attenuated
LPS-induced
neuroinflammation
through
NF-κB
pathway
inhibition
activation
via
Nrf2/HO-1
signalling,
suggesting
these
drugs
could
represent
promising
therapeutic
approach
consequent
shock.
Neuroscience Insights,
Год журнала:
2024,
Номер
19
Опубликована: Янв. 1, 2024
Alzheimer's
disease
(AD)
is
a
progressive
neurological
disorder
characterized
by
wide
range
of
cognitive
and
non-cognitive
impairments.
The
present
study
was
designed
to
investigate
the
potential
effects
cacao
on
performance
identify
role
oxidative
stress
in
an
AD
animal
model
induced
unilateral
intracerebroventricular
(U-ICV)
injection
amyloid
beta
Targets,
Год журнала:
2024,
Номер
2(4), С. 307 - 326
Опубликована: Окт. 16, 2024
Resveratrol,
a
naturally
occurring
polyphenol
found
in
grapes,
berries,
and
peanuts,
has
garnered
significant
attention
for
its
potential
anti-cancer
properties.
This
review
provides
comprehensive
analysis
of
role
cancer
therapy,
both
as
standalone
treatment
combination
with
other
therapeutic
approaches.
explores
the
molecular
mechanisms
underlying
resveratrol’s
effects,
including
antioxidant
activity,
modulation
cellular
signaling
pathways,
antiproliferative
properties,
anti-inflammatory
epigenetic
influences.
also
examines
vitro
vivo
studies
that
highlight
efficacy
against
various
types.
Furthermore,
synergistic
effects
resveratrol
when
used
conjunction
conventional
treatments
like
chemotherapy
radiotherapy,
well
targeted
therapies
immunotherapies,
are
discussed.
Despite
promising
preclinical
results,
this
addresses
challenges
limitations
faced
translating
these
findings
into
clinical
practice,
issues
bioavailability
toxicity.
Finally,
it
outlines
future
research
directions
to
enhance
existing
regimens.
aims
provide
thorough
understanding
identify
areas
further
investigation
quest
effective
treatments.
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4258 - 4258
Опубликована: Дек. 10, 2024
Resveratrol
and
extra
virgin
olive
oil
are
both
recognized
for
their
potential
protective
effects
against
age-related
diseases.
This
overview
highlights
mechanisms
of
action,
health
benefits,
the
scientific
evidence
supporting
roles
in
promoting
longevity
cognitive
health.
A
literature
search
was
conducted.
Important
findings
related
to
clinical
implications
resveratrol
EVOO
were
summarized.
Both
have
complementary
that
may
enhance
anti-aging
effects.
promising
disease-protective
agents.
Their
antioxidant,
anti-inflammatory,
neuroprotective
properties
contribute
improved
outcomes
longevity.
Incorporating
these
compounds
into
a
balanced
diet
offer
significant
benefits
aging
populations,
reducing
risk
chronic
Continued
research
is
essential
fully
understand
optimize
use
settings.
Future
should
focus
on
investigating
synergistic
when
consumed
together,
as
they
each
other’s
bioavailability
efficacy
health;
conducting
extensive
trials
confirm
long-term
various
particularly
individuals;
further
exploring
molecular
pathways
through
which
exert
effects,
including
interactions
with
gut
microbiota
metabolic
pathways.
Anti-Cancer Agents in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(16), С. 1207 - 1219
Опубликована: Июль 11, 2024
With
conventional
cancer
treatments
facing
limitations,
interest
in
plant-derived
natural
products
as
potential
alternatives
is
increasing.
Although
resveratrol
has
demonstrated
antitumor
effects
various
cancers,
its
impact
and
mechanism
on
nasopharyngeal
carcinoma
remain
unclear.
Molecules,
Год журнала:
2024,
Номер
29(22), С. 5314 - 5314
Опубликована: Ноя. 11, 2024
Alzheimer's
disease
(AD)
involves
a
complex
pathophysiology
with
multiple
interconnected
subpathologies,
including
protein
aggregation,
impaired
neurotransmission,
oxidative
stress,
and
microglia-mediated
neuroinflammation.
Current
treatments,
which
generally
target
single
subpathology,
have
failed
to
modify
the
disease's
progression,
providing
only
temporary
symptom
relief.
Multi-target
drugs
(MTDs)
address
several
aggregation
of
pathological
proteins.
In
this
review,
we
cover
hybrid
molecules
published
between
2014
2024.
We
offer
an
overview
strategies
employed
in
drug
design
approaches
that
led
notable
improvements
reduced
hepatotoxicity.
Our
aim
is
insights
into
potential
development
new
drugs.
This
highlights
multi-target
featuring
heterocycles
