International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138760 - 138760
Опубликована: Дек. 1, 2024
Язык: Английский
Redox Biology, Год журнала: 2024, Номер 75, С. 103297 - 103297
Опубликована: Авг. 3, 2024
Cardiovascular disease (CVD) is one of the leading causes mortality in humans, and oxidative stress plays a pivotal role progression. This phenomenon typically arises from weakening cellular antioxidant system or excessive accumulation peroxides. review focuses on specialized form stress-disulfide stress-which triggered by an imbalance glutaredoxin thioredoxin systems within cell, to disulfide bonds. The genesis usually induced extrinsic pathological factors that disrupt thiol-dependent system, manifesting as sustained glutathionylation proteins, formation abnormal intermolecular bonds between cysteine-rich irreversible oxidation thiol groups sulfenic sulfonic acids. Disulfide not only precipitates collapse reactive oxygen species, exacerbating stress, but may also initiate inflammation, autophagy, apoptosis through cascade signaling pathways. Furthermore, this explores detrimental effects progression various CVDs including atherosclerosis, hypertension, myocardial ischemia-reperfusion injury, diabetic cardiomyopathy, cardiac hypertrophy, heart failure. proposes several potential therapeutic avenues improve future treatment CVDs.
Язык: Английский
Процитировано
7
Frontiers in Molecular Biosciences, Год журнала: 2025, Номер 12
Опубликована: Фев. 4, 2025
Intracerebral hemorrhage (ICH) is a non traumatic that occurs in certain part of the brain. It usually leads to brain cell damage. According large number experimental research, oxidative stress an important pathophysiological processes cerebral hemorrhage. In this paper, we aim determine how changes biomarkers indicate damage degree hemorrhage, and explore summarize potential treatments or interventions. We found patients with are characterized by increased levels markers, such as total malondialdehyde (MDA), F2 isoprostaglandin, hydroxynonenal, myeloperoxidase protein hydroxyl. Therefore, caused ICH on these markers can be used evaluate diagnose ICH, predict its prognosis, guide preventive treatment turn antioxidant based new alternative.
Язык: Английский
Процитировано
0
Neurotherapeutics, Год журнала: 2025, Номер unknown, С. e00541 - e00541
Опубликована: Фев. 1, 2025
Some prior studies suggested that supplementation with carnosine or β-alanine can improve cognitive abilities and neurodegenerative disorders in certain elderly at-risk populations. However, the efficacy of improving performance a healthy, adult population has not been assessed. We examined this as post-hoc secondary outcome placebo-controlled, randomized Nucleophilic Defense Against PM Toxicity (NEAT) clinical trial (NCT03314987). Participants were instructed to take either cornstarch (placebo) capsules (2g daily) for up 12wk. Cognitive ability was assessed using Cognition test battery, which consists ten individual tests known engage specific brain systems covering range domains. Speed, accuracy, efficiency obtained whole battery well each tests. Participant testing occurred at baseline, randomization, after approximately 6wk (Follow-up-1), 12wk (Follow-up-2). Of 299 participants who randomized, we useable measures 242 Follow-up-1 231 at Follow-up-2. Age-based stratification (23–35 years, 36–50 51–65 years), showed statistically significant improvements overall speed youngest age group stratum both follow-up visits. This same also demonstrated seven accuracy scores The other groups few no improvements. Thus, study largely devoid susceptibility factors pre-existing conditions, selectively improved high-level young individuals.
Язык: Английский
Процитировано
0
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 339, С. 126290 - 126290
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138760 - 138760
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0