AEBP1 Silencing Protects Against Cerebral Ischemia/Reperfusion Injury by Regulating Neuron Ferroptosis and Microglia M2 Polarization Through PRKCA‐PI3K‐Akt Axis DOI
Yafen Zhang, Yan Li,

Fengli Liu

и другие.

Drug Development Research, Год журнала: 2024, Номер 85(8)

Опубликована: Дек. 1, 2024

ABSTRACT Cerebral ischemia/reperfusion injury is one of the main causes neuronal damage. Neuron ferroptosis and microglia polarization are considered as critical processes during cerebral ischemia/reperfusion. Adipocyte enhancer‐binding protein 1 (AEBP1) usually acts a transcriptional repressor which involved in various diseases. However, it still remains unknown whether AEBP1 could have important roles regulating neuron injury. The oxygen‐glucose deprivation reperfusion (OGD/R)‐treated cells middle artery occlusion (MCAO)‐treated mice were used vitro vivo models. differentially expressed factors analyzed according to GEO datasets. Relative mRNA expression levels detected by qRT‐PCR western blot analysis. Cell viability was measured CCK‐8 assay. ROS, GSH iron contents using specifical assay kits. CD26 CD206 immunofluorescence Inflammatory cytokines ELISA. association between PRKCA assessed luciferase reporter ChIP analyses. damage TTC staining neurological deficit score. Transcription factor increased OGD/R‐treated HT22 BV2 cells. silencing attenuated OGD/R‐induced cell through increasing viability, GPX4 levels, decreasing ACSL4 levels. knockdown promoted M2 CD206‐positive Arg‐1 level, reducing iNOS, TNF‐α, IL‐1β IL‐6 transcriptionally repressed expression, further regulated PI3K/Akt signaling activation. Inhibition or reversed effects on polarization. downregulation infarct size scores MCAO‐treated mice. mitigated activating signaling, indicating potentially protective action

Язык: Английский

Ferroptosis inhibitors: past, present and future DOI Creative Commons
Lei Zhang, Yi Luo, Yang Xiang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 23, 2024

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.

Язык: Английский

Процитировано

17
Ferroptosis role in complexity of cell death: unrevealing mechanisms in Parkinson’s disease and therapeutic approaches DOI
Anupam Awasthi,

Kousik Maparu,

Shamsher Singh

и другие.

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

4
Therapeutic Approaches with Iron Oxide Nanoparticles to Induce Ferroptosis and Overcome Radioresistance in Cancers DOI Creative Commons
Derek B. Sant’Angelo, Géraldine Descamps, Valentin Lecomte

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 325 - 325

Опубликована: Фев. 26, 2025

The emergence of nanotechnology in medicine, particularly using iron oxide nanoparticles (IONPs), may impact cancer treatment strategies. IONPs exhibit unique properties, such as superparamagnetism, biocompatibility, and ease surface modification, making them ideal candidates for imaging, therapeutic interventions. Their application targeted drug delivery, especially with traditional chemotherapeutic agents like cisplatin, has shown potential overcoming limitations low bioavailability systemic toxicity chemotherapies. Moreover, IONPs, by releasing ions, can induce ferroptosis, a form iron-dependent cell death, which offers promising pathway to reverse radio- chemoresistance therapy. In particular, demonstrate significant radiosensitisers, enhancing the effects radiotherapy promoting reactive oxygen species (ROS) generation, lipid peroxidation, modulating tumour microenvironment stimulate antitumour immune responses. This review explores multifunctional roles radiosensitisation through ferroptosis induction, highlighting their promise advancing head neck cancers. Additional research is crucial fully addressing clinical settings, offering novel approach personalised treatment.

Язык: Английский

Процитировано

1
Role of iron in brain development, aging, and neurodegenerative diseases DOI Creative Commons
Qiqi Gao, Yiyang Zhou, Yu Chen

и другие.

Annals of Medicine, Год журнала: 2025, Номер 57(1)

Опубликована: Март 4, 2025

It is now understood that iron crosses the blood-brain barrier via a complex metabolic regulatory network and participates in diverse critical biological processes within central nervous system, including oxygen transport, energy metabolism, synthesis catabolism of myelin neurotransmitters. During brain development, distributed throughout brain, playing pivotal role key such as neuronal myelination, neurotransmitter synthesis. In physiological aging, can selectively accumulate specific regions, impacting cognitive function leading to intracellular redox imbalance, mitochondrial dysfunction, lipid peroxidation, thereby accelerating aging associated pathologies. Furthermore, accumulation may be primary contributor neurodegenerative diseases Alzheimer's Parkinson's diseases. Comprehending diseases, utilizing iron-sensitive Magnetic Resonance Imaging (MRI) technology for timely detection or prediction abnormal neurological states, implementing appropriate interventions instrumental preserving normal system function.

Язык: Английский

Процитировано

1
The role of ferroptosis in neurodegenerative diseases DOI Creative Commons
Yifan Fei,

Yunjie Ding

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 15, 2024

Ferroptosis represents an iron − and lipid peroxidation (LPO)-mediated form of regulated cell death (RCD). Recent evidence strongly suggests the involvement ferroptosis in various neurodegenerative diseases (NDs), particularly Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), multiple sclerosis (MS), amyotrophic lateral (ALS), among others. The treatment poses both opportunities challenges context ND. This review provides a comprehensive overview characteristic features, induction inhibition ferroptosis, highlighting inhibitor underlying mechanisms responsible for its occurrence. Moreover, explores how these contribute to pathogenesis progression major disorders. Additionally, it presents novel insights into role ND summarizes recent advancements development therapeutic approaches targeting ferroptosis. These hold potential guide future strategies aimed at effectively managing debilitating medical conditions.

Язык: Английский

Процитировано

5
Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities DOI Creative Commons

Roberta Veglia Tranchese,

Sabrina Battista, Laura Cerchia

и другие.

Biomolecules, Год журнала: 2024, Номер 14(11), С. 1443 - 1443

Опубликована: Ноя. 13, 2024

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical pathway in cancer biology. This review delves into the epigenetic mechanisms that modulate ferroptosis cells, focusing on how DNA methylation, histone modifications, and non-coding RNAs influence expression function essential genes involved this process. By unraveling complex interplay between these ferroptosis, article sheds light novel gene targets functional insights could pave way for innovative treatments to enhance therapeutic efficacy overcome resistance therapy.

Язык: Английский

Процитировано

5
NINJ1 in Cell Death and Ferroptosis: Implications for Tumor Invasion and Metastasis DOI Open Access
Ssu-Yu Chen,

Ing-Luen Shyu,

Jen‐Tsan Chi

и другие.

Cancers, Год журнала: 2025, Номер 17(5), С. 800 - 800

Опубликована: Фев. 26, 2025

NINJ1 was initially recognized for its role in nerve regeneration and cellular adhesion. Subsequent studies have uncovered participation cancer progression, where regulates critical steps tumor metastasis, such as cell migration invasion. More recently, has emerged a multifunctional protein mediating plasma membrane rupture (PMR) several lytic death processes, including apoptosis, necroptosis, pyroptosis. However, ferroptosis-an iron-dependent form of characterized by lipid peroxidation-remained unclear until 2024. Ferroptosis is suppression mechanism that may be particularly relevant to detached metastatic cells. This review explores the invasion focusing on regulation ferroptosis via non-canonical distinct from other deaths. We discuss process implications metastasis. Furthermore, we recent highlighting diverse roles regulation, canonical function PMR modulating intracellular levels glutathione (GSH) coenzyme A (CoA) interaction with xCT anti-porter. Given been associated suppression, elimination treatment-resistant cells, dormancy, NINJ1's modulation presents promising therapeutic target inhibiting Understanding dual promoting or restraining depending context could open avenues novel anti-cancer strategies enhance ferroptotic vulnerability tumors.

Язык: Английский

Процитировано

0
Cardioprotective potential of transcription factor PRRX1 silencing against myocardial ischemia/reperfusion injury by regulating excessive mitophagy and ferroptosis through FKBP5-p38 MAPK axis DOI

Yongpeng Fang,

Xudong Niu,

Weifang Zhao

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер 1871(5), С. 167766 - 167766

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

0
Lipid metabolism in ferroptosis: mechanistic insights and therapeutic potential DOI Creative Commons
Daoyang Sun, Longfei Wang, Yu‐Hsuan Wu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 11, 2025

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, plays a pivotal role in various physiological and pathological processes. In this review, we summarize the core mechanisms ferroptosis, emphasizing its intricate connections to metabolism, including fatty acid synthesis, phospholipid remodeling, oxidation dynamics. We further highlight advancements detection technologies, such as fluorescence imaging, lipidomics, vivo PET which have deepened our understanding ferroptotic regulation. Additionally, discuss ferroptosis human diseases, where it acts double-edged sword, contributing cancer while also driving ischemia-reperfusion injury neurodegeneration. Finally, explore therapeutic strategies aimed at either inducing or inhibiting iron chelation, antioxidant modulation, lipid-targeted interventions. By integrating mechanistic insights, disease relevance, potential, review provides comprehensive perspective on crucial interface between metabolism oxidative stress.

Язык: Английский

Процитировано

0
Fisetin mitigates cisplatin-induced peripheral neuropathy: a behavioral and immunohistochemical study DOI
Cafer Adıgüzel, Caner Yıldırım, Sena Çevik

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0