Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

и другие.

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Язык: Английский

MiR-370-3p regulate TLR4/SLC7A11/GPX4 to alleviate the progression of glucocorticoids-induced osteonecrosis of the femoral head by promoting osteogenesis and suppressing ferroptosis DOI Creative Commons

Rongtai Zuo,

Bojun Cao, Lingchi Kong

и другие.

Journal of Orthopaedic Translation, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
The application of alkaloids in ferroptosis: A review DOI Creative Commons

Bocheng Fan,

Qihao Guo,

Shu Wang

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117232 - 117232

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

2
Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

и другие.

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Язык: Английский

Процитировано

0