Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Language: Английский

MiR-370-3p regulate TLR4/SLC7A11/GPX4 to alleviate the progression of glucocorticoids-induced osteonecrosis of the femoral head by promoting osteogenesis and suppressing ferroptosis DOI Creative Commons

Rongtai Zuo,

Bojun Cao, Lingchi Kong

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
The application of alkaloids in ferroptosis: A review DOI Creative Commons

Bocheng Fan,

Qihao Guo,

Shu Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117232 - 117232

Published: Aug. 3, 2024

Language: Английский

Citations

2
Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Language: Английский

Citations

0